The immune geography of IgA induction and function

Prokaryotes: The unseen majority

1998 • 4,659 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

The route of re-circulation of lymphocytes in the rat

1964 • 1,449 citations

DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

2002 • 1,246 citations

A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

2000 • 1,085 citations

CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS

1965 • 1,014 citations

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

2006 • 963 citations

BAFF and APRIL: A Tutorial on B Cell Survival

2003 • 946 citations

PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR I<scp>G</scp>A-PRODUCING IMMUNOCYTES IN THE RABBIT

1971 • 756 citations

Baff Mediates Survival of Peripheral Immature B Lymphocytes

2000 • 705 citations

Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

2007 • 702 citations

Chemokines and the Tissue-Specific Migration of Lymphocytes

2002 • 692 citations

TACI is mutant in common variable immunodeficiency and IgA deficiency

2005 • 691 citations

Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

2005 • 659 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

Secretory Immunoglobulins

1968 • 544 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

TACI and BAFF-R mediate isotype switching in B cells

2005 • 523 citations

Plasma-cell homing

2003 • 514 citations

Regulation of the T-Independent Humoral Response by TACI

2001 • 513 citations

The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

1984 • 507 citations

Protective Effect of Rotavirus VP6-Specific IgA Monoclonal Antibodies That Lack Neutralizing Activity

1996 • 487 citations

The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo

1994 • 460 citations

Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine

2002 • 460 citations

Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin.

1984 • 445 citations

Intracellular neutralization of virus by immunoglobulin A antibodies.

1992 • 438 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Impaired IgA class switching in APRIL-deficient mice

2004 • 431 citations

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

2001 • 428 citations

The origin and antigen-dependent distribution of IgA-containing cells in the intestine.

1978 • 422 citations

Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins

1984 • 415 citations

Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties

2005 • 414 citations

Identification of a B-1 B cell–specified progenitor

2006 • 410 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

1999 • 395 citations

Role of IgA versus IgG in the Control of Influenza Viral Infection in the Murine Respiratory Tract

2004 • 395 citations

Antibody diffusion in human cervical mucus

1994 • 368 citations

Mucosal and Glandular Distribution of Immunoglobulin Components: Differential Localization of Free and Bound SC in Secretory Epithelial Cells

1974 • 356 citations

Cellular kinetics of the intestinal immune response to cholera toxoid in rats.

1975 • 353 citations

Identification of proteoglycans as the APRIL-specific binding partners

2005 • 352 citations

Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity

1989 • 351 citations

The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

1991 • 346 citations

Gamma-Globulins: Quantitative Relationships in Human Serum and Nonvascular Fluids

1963 • 346 citations

Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen.

1984 • 334 citations

Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA

1986 • 313 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

Role of J Chain in Secretory Immunoglobulin Formation

2000 • 302 citations

Novel Subunit in Secretory IgA

1970 • 294 citations

Immunoglobulin transport across polarized epithelial cells

2002 • 294 citations

Polarized epithelial membrane traffic: conservation and plasticity

2003 • 292 citations

IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

2001 • 266 citations

Immunoglobulin M and Secretory Immunoglobulin A: Presence of a Common Polypeptide Chain Different from Light Chains

1971 • 245 citations

Innate secretory antibodies protect against natural Salmonella typhimurium infection

2006 • 242 citations

Increase in the Population of Duodenal Immunoglobulin A Plasmocytes in Axenic Mice Associated with Different Living or Dead Bacterial Strains of Intestinal Origin

1978 • 233 citations

Molecular Basis for Hematopoietic/Mesenchymal Interaction during Initiation of Peyer's Patch Organogenesis

2001 • 231 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

IgA production without μ or δ chain expression in developing B cells

2001 • 223 citations

Roundtrip Ticket for Secretory IgA: Role in Mucosal Homeostasis?

2007 • 220 citations

B Cell Antigen Receptor Specificity and Surface Density Together Determine B-1 versus B-2 Cell Development

1999 • 218 citations

Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice

1995 • 215 citations

Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins

2003 • 208 citations

Immunoglobulin‐bearing B cells reconstitute and maintain the murine Ly‐1 B cell lineage

1986 • 205 citations

Mechanisms of Neonatal Mucosal Antibody Protection

2006 • 203 citations

Human secretory immunoglobulin A may contribute to biofilm formation in the gut

2003 • 199 citations

Protection Against Influenza Virus Infection in Polymeric Ig Receptor Knockout Mice Immunized Intranasally with Adjuvant-Combined Vaccines

2002 • 199 citations

Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens

1991 • 195 citations

Isolation and description of a few properties of the β2A-globulin of human serum

1959 • 189 citations

Comparison of mucosal and systemic humoral immune responses and subsequent protection in mice orally inoculated with a homologous or a heterologous rotavirus

1994 • 189 citations

APRIL-Deficient Mice Have Normal Immune System Development

2004 • 186 citations

IgA Class Switch Occurs in the Organized Nasopharynx- and Gut-Associated Lymphoid Tissue, but Not in the Diffuse Lamina Propria of Airways and Gut

2004 • 180 citations

Generation of Polymeric Immunoglobulin Receptor-Deficient Mouse with Marked Reduction of Secretory IgA

1999 • 169 citations

Analyses of Homologous Rotavirus Infection in the Mouse Model

1995 • 169 citations

Alternate Mucosal Immune System: Organized Peyer’s Patches Are Not Required for IgA Responses in the Gastrointestinal Tract

2000 • 161 citations

Ontogeny of the Mucosal Immune System and IgA Deficiency

1991 • 159 citations

Secretory Component Delays the Conversion of Secretory IgA into Antigen-Binding Competent F(ab′)2: A Possible Implication for Mucosal Defense

1998 • 156 citations

Gut IgA Class Switch Recombination in the Absence of CD40 Does Not Occur in the Lamina Propria and Is Independent of Germinal Centers

2006 • 153 citations

Signaling via LTβR on the lamina propria stromal cells of the gut is required for IgA production

2002 • 152 citations

Adaptation of Solitary Intestinal Lymphoid Tissue in Response to Microbiota and Chemokine Receptor CCR7 Signaling

2006 • 152 citations

Immunity to Rotavirus in T Cell Deficient Mice

1997 • 147 citations

Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice

1995 • 144 citations

Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse

2006 • 142 citations

Mucosal Immunity to Influenza Without IgA: An IgA Knockout Mouse Model

1999 • 141 citations

Lack of J Chain Inhibits the Transport of Gut IgA and Abrogates the Development of Intestinal Antitoxic Protection

1999 • 137 citations

Early appearance of "natural" mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies.

1995 • 132 citations

Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils

2005 • 130 citations

Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System

2000 • 124 citations

Heterologous Protection Induced by the Inner Capsid Proteins of Rotavirus Requires Transcytosis of Mucosal Immunoglobulins

2002 • 118 citations

B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

2003 • 115 citations

The Role of Somatic Mutation in the Generation of the Protective Humoral Immune Response against Vesicular Stomatitis Virus

1996 • 110 citations

BAFFled B cells survive and thrive: roles of BAFF in B-cell development

2002 • 110 citations

Layers of mutualism with commensal bacteria protect us from intestinal inflammation

2006 • 107 citations

Transcriptional regulation of the mucosal IgA system

2004 • 107 citations

Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues

1989 • 106 citations

Solution Structure Determination of Monomeric Human IgA2 by X-ray and Neutron Scattering, Analytical Ultracentrifugation and Constrained Modelling: A Comparison with Monomeric Human IgA1

2004 • 104 citations

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili

2005 • 104 citations

Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria

1996 • 104 citations

Polymeric Immunoglobulin Receptor in Intestinal Immune Defense against the Lumen-Dwelling Protozoan ParasiteGiardia

2006 • 99 citations

Immunoglobulin G is the main protective antibody in mouse vaginal secretions after vaginal immunization with attenuated herpes simplex virus type 2

1997 • 97 citations

Serum and Secretory IgA in Axenic and Holoxenic Mice

1971 • 95 citations

Intestinal Mucosal Memory and Presence of Memory Cells in Lamina Propria and Peyer's Patches in Mice 2 Years after Oral Immunization with Cholera Toxin

1986 • 92 citations

Immunoglobulin Transport and the Polymeric Immunoglobulin Receptor

2005 • 90 citations

Protection against Cholera Toxin after Oral Immunization is Thymus‐Dependent and Associated with Intestinal Production of Neutralizing IgA Antitoxin

1987 • 89 citations

Restricted IgA Repertoire in Both B-1 and B-2 Cell-Derived Gut Plasmablasts

2005 • 88 citations

IgA Immunodeficiency Leads to Inadequate Th Cell Priming and Increased Susceptibility to Influenza Virus Infection

2001 • 88 citations

Enhanced IgA Class Switching in Marginal Zone and B1 B Cells Relative to Follicular/B2 B Cells

2006 • 87 citations

Vaccine‐induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies

2004 • 82 citations

Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora

2007 • 82 citations

Protection of the Villus Epithelial Cells of the Small Intestine from Rotavirus Infection Does Not Require Immunoglobulin A

2000 • 81 citations

The effect of an IgA1 protease on immunoglobulins bound to the sperm surface and sperm cervical mucus penetrating ability

1987 • 80 citations

Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.

1995 • 79 citations

Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses

2006 • 78 citations

Role of Gut-Associated Lymphoreticular Tissues in Antigen-Specific Intestinal IgA Immunity

2004 • 75 citations

IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection.

1996 • 74 citations

Differential regulation of IgA production by TGF-β and IL-5: TGF-β induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells

1992 • 74 citations

Immunoglobulins in Intact, Immunized, and Contaminated Axenic Mice: Study of Serum IgA

1971 • 73 citations

Immunity to vaginal HSV‐2 infection in immunoglobulin A knockout mice

1998 • 53 citations

Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.

1998 • 42 citations

B Cell-Specific Deficiency for Smad2 In Vivo Leads to Defects in TGF-β-Directed IgA Switching and Changes in B Cell Fate

2006 • 39 citations

Protection against rotavirus shedding after intranasal immunization of mice with a chimeric VP6 protein does not require intestinal IgA

2006 • 37 citations

Mucosal aspects of primary B-cell deficiency and gastrointestinal infections

1995 • 37 citations

Solution Structure of Human Secretory Component and Implications for Biological Function

2007 • 36 citations

Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes

1998 • 36 citations

The Protective Effect of Antibody in Immunity to Murine Chlamydial Genital Tract Reinfection Is Independent of Immunoglobulin A

2005 • 34 citations

Genetic control of the murine immune response to cholera toxin.

1985 • 34 citations

[Immuno-electrophoretic studies on human milk proteins. II].

1959 • 33 citations

Requirements for B7-CD28 Costimulation in Mucosal IgA Responses: Paradoxes Observed in CTLA4-Hγ1 Transgenic Mice

1998 • 33 citations

The discovery of secretory IgA and the mucosal immune system

1993 • 29 citations