The mitochondrial permeability transition pore and its role in cell death
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References (197)
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
1985 • 5,488 citations
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 • 5,133 citations
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
1998 • 4,383 citations
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 • 4,031 citations
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 • 3,603 citations
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
1997 • 3,130 citations
Two CD95 (APO-1/Fas) signaling pathways
1998 • 3,045 citations
The mitochondrial permeability transition
1995 • 2,412 citations
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
1990 • 2,204 citations
Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses
1998 • 2,130 citations
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
1995 • 1,968 citations
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
1995 • 1,892 citations
Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis
1997 • 1,851 citations
Mechanisms by which mitochondria transport calcium
1990 • 1,630 citations
Bax directly induces release of cytochrome c from isolated mitochondria
1998 • 1,514 citations
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
1996 • 1,456 citations
Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria
1997 • 1,389 citations
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy
1998 • 1,381 citations
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
1990 • 1,369 citations
Mitochondrial control of nuclear apoptosis.
1996 • 1,363 citations
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
1998 • 1,226 citations
Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
1998 • 1,183 citations
Microdomains with High Ca 2+ Close to IP 3 -Sensitive Channels that Are Sensed by Neighboring Mitochondria
1993 • 1,167 citations
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.
1996 • 1,143 citations
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
1998 • 1,143 citations
Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization
1998 • 1,132 citations
Cytosol-to-membrane redistribution of Bax and Bcl-XLduring apoptosis
1997 • 1,117 citations
Phospholipid synthesis in a membrane fraction associated with mitochondria.
1990 • 1,051 citations
Inhibition of Bax Channel-Forming Activity by Bcl-2
1997 • 1,023 citations
Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria
1998 • 932 citations
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
1998 • 872 citations
Mitochondrial permeability transition is a central coordinating event of apoptosis.
1996 • 857 citations
Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.
1988 • 846 citations
Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
1995 • 830 citations
Calcium in Ischemic Cell Death
1998 • 818 citations
Cytochrome c: Can't Live with It—Can't Live without It
1997 • 768 citations
Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals
1997 • 739 citations
Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase
1990 • 738 citations
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
1999 • 730 citations
The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins
1998 • 700 citations
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.
1992 • 692 citations
Role of mitochondria in oxidative stress and ageing
1998 • 649 citations
Regulated Targeting of BAX to Mitochondria
1998 • 617 citations
Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death
1999 • 610 citations
Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase
1997 • 588 citations
Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts
1993 • 571 citations
Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity
1992 • 561 citations
Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
1994 • 561 citations
The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents
1994 • 527 citations
Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex
1998 • 523 citations
Calcium-Mediated Mechanisms in Chemically Induced Cell Death
1992 • 518 citations
Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart
1998 • 494 citations
Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore
1998 • 475 citations
Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region
1995 • 471 citations
Control of apoptosis by the cellular ATP level
1996 • 465 citations
Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel
1996 • 460 citations
Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.
1992 • 449 citations
The Ca2+-induced membrane transition in mitochondria
1979 • 442 citations
The effect of hyperoxia on superoxide production by lung submitochondrial particles
1982 • 442 citations
Regulation of cellular energy metabolism
1982 • 433 citations
Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca2+
1996 • 421 citations
The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling
1998 • 419 citations
The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian Tissues
1978 • 402 citations
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.
1993 • 390 citations
Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide
1995 • 384 citations
Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition
1998 • 381 citations
The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria
1978 • 380 citations
Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death
1998 • 372 citations
The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A
1991 • 368 citations
Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart.
1990 • 368 citations
Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin
1998 • 360 citations
Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss
1995 • 356 citations
Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases
1998 • 342 citations
VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function
1997 • 337 citations
Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore
1996 • 336 citations
Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species
1997 • 336 citations
Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury
1998 • 334 citations
Amiloride delays the ischemia-induced rise in cytosolic free calcium.
1991 • 333 citations
Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria
1987 • 332 citations
Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.
1993 • 315 citations
Mitochondrial calcium transport
1980 • 304 citations
The Shape of Cell Death
1997 • 302 citations
Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer
1998 • 301 citations
On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury
1993 • 295 citations
Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
1993 • 294 citations
Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress
1988 • 293 citations
Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes
1991 • 277 citations
Imaging the hierarchical Ca2+ signalling system in HeLa cells.
1997 • 275 citations
Imaging the Permeability Pore Transition in Single Mitochondria
1998 • 269 citations
The Calcium‐Induced and Sodium‐Induced Effluxes of Calcium from Heart Mitochondria
1977 • 265 citations
Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A
1991 • 261 citations
Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes
1997 • 254 citations
Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.
1996 • 247 citations
Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial‐generated reactive oxygen species
1996 • 246 citations
Transient Mitochondrial Depolarizations Reflect Focal Sarcoplasmic Reticular Calcium Release in Single Rat Cardiomyocytes
1998 • 242 citations
Ca2+ transport by mammalian mitochondria and its role in hormone action
1985 • 242 citations
Solution structure of the cyclosporin A/cyclophilin complex by NMR
1993 • 241 citations
The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites
1996 • 233 citations
Modulation of the mitochondrial megachannel by divalent cations and protons.
1992 • 232 citations
Free energy change of ATP-hydrolysis: a causal factor of early hypoxic failure of the myocardium?,
1982 • 231 citations
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.
1993 • 225 citations
Do mitochondrial DNA fragments promote cancer and aging?
1988 • 224 citations
The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria
1989 • 224 citations
Pro‐oxidants and mitochondrial Ca2+: their relationship to apoptosis and oncogenesis
1993 • 218 citations
Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin
1991 • 217 citations
Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.
1974 • 212 citations
Nucleotide Metabolism and Cellular Damage in Myocardial Ischemia
1985 • 212 citations
The relationship between mitochondrial state, ATP hydrolysis, [Mg2+]i and [Ca2+]i studied in isolated rat cardiomyocytes.
1996 • 211 citations
Intracellular calcium regulation
1991 • 210 citations
Release of Cytochrome c from Liver Mitochondria during Permeability Transition
1997 • 197 citations
The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59)
1993 • 192 citations
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.
1993 • 191 citations
Cyclophilin catalyzes protein folding in yeast mitochondria.
1995 • 191 citations
Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.
1994 • 190 citations
Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin
1992 • 189 citations
The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria
1978 • 188 citations
Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases
1997 • 188 citations
Involvement of the ADPATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: Importance of the orientation of the nucleotide binding site
1988 • 186 citations
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation
1993 • 181 citations
On the Voltage Dependence of the Mitochondrial Permeability Transition Pore
1997 • 179 citations
Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.
1992 • 177 citations
The Thiol-specific Antioxidant Enzyme Prevents Mitochondrial Permeability Transition
1998 • 174 citations
The reversible Ca2+-induced permeabilization of rat liver mitochondria
1986 • 174 citations
Cytosolic free Ca2+ in single rat heart cells during anoxia and reoxygenation
1987 • 170 citations
Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum
1991 • 168 citations
A heart mitochondrial Ca2+-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states
1990 • 168 citations
Correspondence
1996 • 164 citations
Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca2+ and Oxidant Stress
1996 • 163 citations
Early apoptosis in human myocardial infarcts
1997 • 158 citations
Chromatin condensation during apoptosis requires ATP
1996 • 157 citations
Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides
1980 • 157 citations
Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+]m overload in rat hearts
1996 • 154 citations
Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore
1998 • 152 citations
The mitochondrial outer membrane channel, VDAC, is regulated by a synthetic polyanion
1987 • 150 citations
Platelet Activation by Superoxide Anion and Hydroxyl Radicals Intrinsically Generated by Platelets That Had Undergone Anoxia and Then Reoxygenated
1997 • 149 citations
Mitochondria Support Inositol 1,4,5-Trisphosphate-mediated Ca2+ Waves in Cultured Oligodendrocytes
1996 • 147 citations
The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.
1992 • 146 citations
Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate
1999 • 140 citations
Dehydrogenase activation by Ca2+ in cells and tissues
1991 • 131 citations
Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization
1993 • 128 citations
Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study
1995 • 128 citations
Energy relationships between cytosolic metabolism and mitochondrial respiration in rat heart
1978 • 127 citations
Tissue‐specific transcription pattern of the adenine nucleotide translocase isoforms in humans
1997 • 122 citations
Cytochrome C Is Released from Mitochondria Into the Cytosol after Cerebral Anoxia or Ischemia
1999 • 122 citations
Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.
1994 • 119 citations
Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism
1998 • 111 citations
The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria
1990 • 104 citations
Involvement of contact sites in phosphatidylserine import into liver mitochondria
1991 • 104 citations
Prodomains – adaptors – oligomerization: the pursuit of caspase activation in apoptosis
1999 • 103 citations
Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress
1992 • 96 citations
Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1
1997 • 96 citations
The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides
1980 • 94 citations
Cyclosporin a protects hepatocytes against prooxidant-induced cell killing
1992 • 94 citations
FREQUENCY-DEPENDENT SELECTION FOR PLASMID-CONTAINING CELLS OF ESCHERICHIA COLI
1979 • 94 citations
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.
1994 • 94 citations
Biophysical analysis of novel transport pathways induced in red blood cell membranes
1987 • 90 citations
On the involvement of a mitochondrial pore in reperfusion injury
1993 • 86 citations
Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells
1998 • 86 citations
Na+/H+ exchange and its inhibition in cardiac ischemia and reperfusion
1993 • 85 citations
Reoxygenation injury and antioxidant protection: A tale of two paradoxes
1990 • 81 citations
The Enzymes of Biological Membranes
1976 • 81 citations
Human Cyclophilin C: Primary Structure, Tissue Distribution, and Determination of Binding Specificity for Cyclosporins
1994 • 80 citations
Power transmission along biological membranes
1990 • 79 citations
Structure-Based Design of a Cyclophilin-Calcineurin Bridging Ligand
1993 • 78 citations
Mitochondrial dysfunction during anoxia/reoxygenation injury of liver sinusoidal endothelial cells
1994 • 75 citations
Catalysis of proline isomerization during protein-folding reactions
1988 • 73 citations
A nuclear RNA‐binding cyclophilin in human T cells
1996 • 72 citations
A comparative study of cytochrome ratios in mitochondria from organs of the rat, chicken, and guinea pig
1968 • 69 citations
The pathway of adenine nucleotide catabolism and its control in isolated rat hepatocytes subjected to anoxia
1982 • 68 citations
Human T cell cyclophilin18 binds to thiol-specific antioxidant protein Aop1 and stimulates its activity 1 1Edited by M. Yaniv
1998 • 68 citations
Cytosolic free calcium in chick heart cells its role in cell injury
1985 • 65 citations
Activity of the Mitochondrial Multiple Conductance Channel Is Independent of the Adenine Nucleotide Translocator
1996 • 63 citations
The resolution of calcium fluxes in heart and liver mitochondria using the lanthanide series
1979 • 60 citations
Evidence for the Involvement of a Membrane‐Associated Cyclosporin‐A‐Binding Protein in the Ca2+‐Activated Inner Membrane Pore of Heart Mitochondria
1995 • 53 citations
Calcium and sodium control in hypoxic-reoxygenated cardiomyocytes
1993 • 53 citations
The N-Terminal Cyclophilin-Homologous Domain of a 150-Kilodalton Tumor Recognition Molecule Exhibits Both Peptidylprolyl cis-trans-Isomerase and Chaperone Activities
1994 • 52 citations
Microcompartmentation of energy metabolism at the outer mitochondrial membrane: Role in diabetes mellitus and other diseases
1994 • 50 citations
Co-localization of Calcium-modulating Cyclophilin Ligand with Intracellular Calcium Pools
1998 • 49 citations
The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction
1992 • 46 citations
Role of toxic effects of oxygen in reperfusion damage
1988 • 46 citations
On the interactions of Ca2+ and cyclosporin A with a mitochondrial inner membrane pore: a study using cobaltammine complex inhibitors of the Ca2+ uniporter
1994 • 46 citations
Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals.
1992 • 43 citations
Binding of the Fluorescein Derivative Eosin Y to the Mitochondrial ADP/ATP Carrier: Characterization of the Adenine Nucleotide Binding Site
1998 • 42 citations
The entrapment of the Ca2+ indicator arsenazo III in the matrix space of rat liver mitochondria by permeabilization and resealing. Na+-dependent and -independent effluxes of Ca2+ in arsenazo III-loaded mitochondria
1986 • 42 citations
Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c
1996 • 41 citations
The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction
1992 • 37 citations
An ADP‐sensitive cyclosporin‐A‐binding protein in rat liver mitochondria
1994 • 36 citations
Immunoelectron microscopic study of the distribution of porin on outer membranes of rat heart mitochondria
1995 • 27 citations
Calcium and magnesium transport by in situ mitochondria: electron probe analysis of vascular smooth muscle.
1987 • 26 citations
NG-Nitro-l-arginine methyl ester reduces necrotic but not apoptotic cell death induced by reversible focal ischemia in rat
1996 • 25 citations
Quantitative microchemical imaging of calcium in NaK pump inhibited heart cells
1988 • 18 citations
The mitochondrial ATP / ADP carrier: Interaction with detergents and purification by a novel procedure
1994 • 17 citations
Solution Conformation of a Cyclophilin-Bound Proline Isomerase Substrate
1994 • 16 citations
Effects of adrenergic agonists and mitochondrial energy state on the calcium transport systems of mitochondria
1987 • 15 citations
Dependence of the conformational state of the isolated adenine nucleotide carrier protein on the detergent used for solubilization
1986 • 13 citations
Contact sites and transport in mitochondria.
1995 • 7 citations
Synthesis and release of ATP by soluble mitochondrial F1 in complex with its inhibitor protein during dimethylsulfoxide‐water transitions
1998 • 6 citations
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