Regulated Targeting of BAX to Mitochondria

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Polypeptide and phospholipid composition of the membrane of rat liver peroxisomes: comparison with endoplasmic reticulum and mitochondrial membranes.

1982 • 374 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum

1997 • 322 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus

1994 • 167 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.

1996 • 144 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

A signal-anchor sequence selective for the mitochondrial outer membrane.

1992 • 111 citations

Bcl-XL Cooperatively Associates with the Bap31 Complex in the Endoplasmic Reticulum, Dependent on Procaspase-8 and Ced-4 Adaptor

1998 • 86 citations

Reversal of the Orientation of an Integral Protein of the Mitochondrial Outer Membrane

1992 • 68 citations

Maturation of the antibody response to the major epitope on the self antigen mouse cytochrome c. Restricted V gene usage, selected mutations, and increased affinity.

1996 • 22 citations

Insertion of an uncharged polypeptide into the mitochondrial inner membrane does not require a trans-bilayer electrochemical potential: effects of positive charges

1995 • 18 citations

Deleted Work

1955 • 0 citations