Evidence for the Involvement of a Membrane‐Associated Cyclosporin‐A‐Binding Protein in the Ca²⁺‐Activated Inner Membrane Pore of Heart Mitochondria

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Specific incorporation of cyclophilin A into HIV-1 virions

1994 • 736 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA

1991 • 399 citations

Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart.

1990 • 368 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

Peptidylproline cis‐trans‐isomerases: immunophilins

1993 • 349 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

1993 • 245 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Cyclophilin: distribution and variant properties in normal and neoplastic tissues.

1986 • 214 citations

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1992 • 189 citations

A heart mitochondrial Ca2+-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states

1990 • 168 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

Magnesium-Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporine-A and ADP

1994 • 110 citations

The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria

1990 • 104 citations

Mitochondrial protein import: Specific recognition and membrane translocation of preproteins

1993 • 102 citations

Cyclophilins: a new family of proteins involved in intracellular folding

1992 • 100 citations

Substituted trifluoroketones as potent, selective inhibitors of mammalian carboxylesterases

1987 • 60 citations

The N-Terminal Cyclophilin-Homologous Domain of a 150-Kilodalton Tumor Recognition Molecule Exhibits Both Peptidylprolyl cis-trans-Isomerase and Chaperone Activities

1994 • 52 citations

The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction

1992 • 46 citations

On the interactions of Ca2+ and cyclosporin A with a mitochondrial inner membrane pore: a study using cobaltammine complex inhibitors of the Ca2+ uniporter

1994 • 46 citations

Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals.

1992 • 43 citations

An ADP‐sensitive cyclosporin‐A‐binding protein in rat liver mitochondria

1994 • 36 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporin binding protein

1989 • 26 citations

Basic research in cardiology focussed issue on ?energy and cation control in ischemia-reperfusion?

1993 • 2 citations