Dehydrogenase activation by Ca2+ in cells and tissues

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

OXIDATIVE PHOSPHORYLATIONS: RÔLE OF INORGANIC PHOSPHATE AND ACCEPTOR SYSTEMS IN CONTROL OF METABOLIC RATES

1952 • 744 citations

The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution

1974 • 707 citations

Cytosolic calcium oscillators

1988 • 690 citations

Metabolite Transport in Mitochondria

1979 • 618 citations

Quantification of the contribution of various steps to the control of mitochondrial respiration.

1982 • 617 citations

On cytochrome, a respiratory pigment, common to animals, yeast, and higher plants

1925 • 533 citations

Calcium oscillations.

1990 • 520 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Pancreatic islet glucose metabolism and regulation of insulin secretion

1986 • 506 citations

Myocardial contractile function during ischemia and hypoxia.

1987 • 486 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

Regulation of cellular energy metabolism

1982 • 433 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Relation Between Work and Phosphate Metabolite in the in Vivo Paced Mammalian Heart

1986 • 383 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Characterization of Cytosolic Calcium Oscillations Induced by Phenylephrine and Vasopressin in Single Fura-2-loaded Hepatocytes

1989 • 369 citations

Relation between mitochondrial calcium transport and control of energy metabolism

1985 • 362 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo

1985 • 356 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

A survey of the interaction of calcium ions with mitochondria from different tissues and species

1971 • 339 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

A Ca2+-insensitive form of fura-2 associated with polymorphonuclear leukocytes. Assessment and accurate Ca2+ measurement.

1987 • 317 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart

1977 • 296 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1991 • 277 citations

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

1970 • 270 citations

α-Glycerophosphate Oxidase of Flight Muscle Mitochondria

1958 • 260 citations

Multiple controls of oxidative metabolism in living tissues as studied by phosphorus magnetic resonance.

1986 • 256 citations

α-Keto acid dehydrogenase complexes

1972 • 244 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactate

1977 • 234 citations

Activities of potassium and sodium ions in rabbit heart muscle.

1975 • 214 citations

Mitochondrial respiratory control. Evidence against the regulation of respiration by extramitochondrial phosphorylation potentials or by [ATP]/[ADP] ratios.

1982 • 211 citations

Simultaneous measurement of Ca2+, contraction, and potential in cardiac myocytes

1990 • 211 citations

Control of mitochondrial respiration

1983 • 210 citations

Ca2+ Oscillations Induced by Hormonal Stimulation of Individual Fura-2-loaded Hepatocytes

1989 • 195 citations

High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide.

1981 • 189 citations

The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria

1978 • 188 citations

Regulation of Citric Acid Cycle by Calcium

1989 • 187 citations

Intramitochondrial and Extramitochondrial Concentrations of Adenine Nucleotides and Inorganic Phosphate in Isolated Hepatocytes from Fasted Rats

1978 • 176 citations

Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2

1990 • 175 citations

Integration of Mitochondrial Function

1988 • 165 citations

Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells

1984 • 164 citations

Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells.

1988 • 158 citations

Function of calcium ions in pyruvate dehydrogenase phosphatase activity

1972 • 157 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Properties of the Ca2+-sensitive dehydrogenases within intact uncoupled mitochondria from the white and brown adipose tissue of the rat

1980 • 157 citations

The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly flight-muscle mitochondria

1967 • 154 citations

Regulation of functional muscarinic receptor expression in tracheal smooth muscle cells

1991 • 154 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+

1984 • 151 citations

Control of Mitochondrial Substrate Oxidation

1980 • 151 citations

Effect of nicotinamide adenine dinucleotide on the membrane-associated reduced nicotinamide adenine dinucleotide oxidase of Mycobacterium phlei.

1975 • 145 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

1985 • 139 citations

Free magnesium in sheep, ferret and frog striated muscle at rest measured with ion‐selective micro‐electrodes

1982 • 135 citations

Control of Mitochondrial Respiration in the Heart In Vivo

1990 • 134 citations

The Effective Proton Conductance of the Inner Membrane of Mitochondria from Brown Adipose Tissue

1977 • 133 citations

A Kinetic Study of the Energy‐Linked Influx of Ca²⁺ into Heart Mitochondria

1976 • 131 citations

Aspects of energy-linked calcium accumulation by rat heart mitochondria.

1975 • 131 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Regulation of Mammalian Pyruvate and Branched-Chain α-Keto Acid Dehydrogenase Complexes by Phosphorylation — Dephosphorylation

1985 • 126 citations

Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios

1988 • 124 citations

Regulation of Mitochondrial α-Ketoglutarate Metabolism by Product Inhibition at α-Ketoglutarate Dehydrogenase

1974 • 123 citations

Physiological and bioenergetic aspects of mitochondrial calcium transport

1983 • 122 citations

The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+

1987 • 121 citations

The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets

1987 • 119 citations

Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart

1983 • 119 citations

Sensitivity of the response of cytosolic calcium in Quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides.

1985 • 119 citations

Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart

1971 • 115 citations

Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney

1982 • 115 citations

Intrinsic uncoupling of mitochondrial proton pumps. 1. Nonohmic conductance cannot account for the nonlinear dependence of static head respiration on .DELTA.~.mu.H

1986 • 114 citations

Cytosolic free Ca²⁺ in isolated rat hepatocytes as measured by quin2

1984 • 111 citations

Measurement of intrasynaptosomal free calcium by using the fluorescent indicator quin-2

1984 • 111 citations

³¹P‐NMR studies of respiratory regulation in the intact myocardium

1986 • 111 citations

Control of gluconeogenesis in rat liver cells. I. Kinetics of the individual enzymes and the effect of glucagon.

1983 • 110 citations

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1988 • 110 citations

Monitoring cytosolic free magnesium in cultured chicken heart cells by use of the fluorescent indicator Furaptra.

1989 • 108 citations

Hydrogen transport and transport metabolites

1963 • 107 citations

Studies on mitochondrial Ca2+-transportand matrix Ca2+ using fura-2-loaded rat heart mitochondria

1989 • 103 citations

The Regulation of Mitochondrial Calcium Transport in Heart

1985 • 102 citations

Subcellular calcium and magnesium mobilization in rat liver stimulated in vivo with vasopressin and glucagon.

1987 • 98 citations

Ca2+ stimulation of rat liver mitochondrial glycerophosphate dehydrogenase.

1981 • 97 citations

Estimation of intramitochondrial pCa and pH by fura-2 and 2,7 biscarboxyethyl-5(6)-carboxyfluorescein (BCECF) fluorescence

1987 • 96 citations

Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles

1984 • 95 citations

Total and free myoplasmic calcium during a contraction cycle: x‐ray microanalysis in guinea‐pig ventricular myocytes.

1991 • 94 citations

Regulation of oxidative phosphorylation in mitochondria by external free Ca2+ concentrations.

1985 • 94 citations

Synergistic stimulation of the Ca2+ influx in rat hepatocytes by glucagon and the Ca2+-linked hormones vasopressin and angiotensin II.

1985 • 94 citations

A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources

1981 • 91 citations

Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation

1990 • 91 citations

Changes in pyridine nucleotide levels alter oxygen consumption and extra-mitochondrial phosphates in isolated mitochondria: A 31P-NMR and NAD(P)H fluorescence study

1987 • 90 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Studies on the Mitochondrial α-Glycerophosphate Dehydrogenase

1959 • 88 citations

Respiration of rat lung mitochondria and the influence of Ca²⁺ on substrate utilization

1973 • 88 citations

The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria.

1975 • 86 citations

Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

1985 • 84 citations

Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using31P n.m.r. and ruthenium red

1989 • 84 citations

Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes

1987 • 83 citations

Intramitochondrial and extramitochondrial free calcium ion concentrations of suspensions of heart mitochondria with very low, plausibly physiological, contents of total calcium

1982 • 82 citations

Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2

1987 • 82 citations

Relationship between Oxygen Uptake of Perifused Rat-Liver Cells and the Cytosolic Phosphorylation State Calculated from Indicator Metabolites and a Redetermined Equilibrium Constant

1978 • 81 citations

Mechanism of pyruvate dehydrogenase activation by increased cardiac work

1983 • 80 citations

Relations between extramitochondrial and intramitochondrial adenine nucleotide systems

1981 • 78 citations

Conversion of esterified fura-2 and indo-1 to Ca2+-sensitive forms by mitochondria

1988 • 77 citations

Vasopressin and/or glucagon rapidly increases mitochondrial calcium and oxidative enzyme activities in the perfused rat liver.

1986 • 77 citations

Hormone-induced changes in NADH fluorescence and O2 consumption of rat hepatocytes

1982 • 75 citations

The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production

1980 • 75 citations

The relation between the effects of veratridine on action potential and contraction in mammalian ventricular myocardium

1975 • 75 citations

Glycerol‐3‐Phosphate Shuttle and Its Function in Intermediary Metabolism of Hamster Brown‐Adipose Tissue

1975 • 75 citations

The calcium-binding ATPase inhibitor protein from bovine heart mitochondria. Purification and properties.

1988 • 71 citations

Pyruvate Carboxylase

1974 • 71 citations

Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver.

1982 • 70 citations

A phosphorus-31 nuclear magnetic resonance study of the metabolic, contractile, and ionic consequences of induced calcium alterations in the isovolumic rat heart.

1986 • 70 citations

Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets

1990 • 70 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

Regulation of bovine kidney .alpha.-ketoglutarate dehydrogenase complex by calcium ion and adenine nucleotides. Effects on S0.5 for .alpha.-ketoglutarate

1981 • 69 citations

Contribution of the translocator of adenine nucleotides and the ATP synthase to the control of oxidative phosphorylation and arsenylation in liver mitochondria.

1985 • 69 citations

Effect of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate

1981 • 68 citations

The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents

1981 • 68 citations

Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase

1976 • 68 citations

Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte

1990 • 67 citations

Activation of mitochondrial oxidative metabolism by calcium ions in Limulusventral photoreceptor

1988 • 65 citations

Stimulation by α-adrenergic agonists of Ca2+ fluxes, mitochondrial oxidation and gluconeogenesis in perfused rat liver

1983 • 65 citations

The mechanism of the hormonal activation of respiration in isolated hepatocytes and its importance in the regulation of gluconeogenesis

1986 • 64 citations

Control of sn-glycerql 3-phosphate oxidation in brown adipose tissue mitochondria by calcium and ACYL-CoA

1974 • 61 citations

Bradykinin contribution to renal blood flow effect of angiotensin converting enzyme inhibitor in the conscious sodium-restricted dog.

1990 • 60 citations

Intrinsic uncoupling of mitochondrial proton pumps. 2. Modeling studies

1986 • 59 citations

Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon

1983 • 57 citations

4 β-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes

1986 • 56 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

Inhibition of bovine kidney .alpha.-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5'-diphosphate on reduced nicotinamide adenine dinucleotide inhibition

1981 • 53 citations

Oxygen uptake occurs faster than sodium pumping in bee retina after a light flash

1983 • 53 citations

Calcium and proton activities in rat cardiac mitochondria. Effect of matrix environment on behaviour of fluorescent probes

1989 • 52 citations

Calcium ions and the regulation of pyruvate dehydrogenase.

1974 • 52 citations

Energy metabolism and contractile function in rat heart during graded, isovolumic perfusion using 31P nuclear magnetic resonance spectroscopy

1987 • 52 citations

Substrate dependence of metabolic state and coronary flow in perfused rat heart

1985 • 49 citations

The Ca2+ and Mg2+ dependence of Ca2+ uptake and respiratory function of porcine heart mitochondria. Probable physiological significance during the cardiac contraction-relaxation cycle.

1982 • 46 citations

Time course of alpha1-adrenergic and vasopressin actions on phosphorylase activation, calcium efflux, pyridine nucleotide reduction, and respiration in hepatocytes.

1983 • 46 citations

The malate/aspartate shuttle and pyruvate kinase as targets involved in the stimulation of gluconeogenesis by phenylephrine

1986 • 46 citations

Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria.

1977 • 44 citations

Changes in free-calcium levels and pH in synaptosomes during transmitter release

1984 • 44 citations

The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomes

1980 • 44 citations

Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca²⁺ in fura‐2‐loaded heart mitochondria

1988 • 42 citations

Effect of phenylephrine on glutamate and glutamine metabolism in isolated perfused rat liver

1984 • 41 citations

Excitation?Contraction coupling in frog heart

1974 • 41 citations

Regulation of gluconeogenesis by norepinephrine, vasopressin, and angiotensin II: A comparative study in the absence and presence of extracellular Ca2+

1983 • 41 citations

Distinct effects of glucagon and vasopressin on proline metabolism in isolated hepatocytes. The role of oxoglutarate dehydrogenase

1984 • 39 citations

Ca2+-regulated release of an ATPase inhibitor protein from submitochondrial particles derived from skeletal muscles of the rat.

1980 • 38 citations

A re-evaluation of conditions required for an accurate estimation of the extramitochondrial ATPADP ratio in isolated rat-liver mitochondria

1984 • 36 citations

Sites of action of glucagon and other Ca2+ mobilizing hormones on the malate aspartate cycle

1988 • 36 citations

Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes

1982 • 36 citations

Contraction and sarcoplasmic reticulum Ca2+ content in single myocytes of guinea pig heart: effect of ryanodine

1990 • 35 citations

Comparative Studies on the Influence of Hormones on Metabolite Compartmentation in Isolated Liver Cells during Gluconeogenesis from Lactate

1978 • 34 citations

Stimulation of the respiration rate of rat liver mitochondria by sub-micromolar concentrations of extramitochondrial Ca2+

1987 • 34 citations

Two components of coupling calcium in single ventricular cell of rabbits and rats

1988 • 34 citations

Effects of Calcium Ions on the Activation of Gluconeogenesis by Norepinephrine in Perfused Rat Liver

1980 • 34 citations

The glucagon-induced activation of pyruvate dehydrogenase in hepatocytes is diminished by 4β-phorbol 12-myristate 13-acetate. A role for cytoplasmic Ca2+ in dehydrogenase regulation

1987 • 32 citations

Control of energy metabolism by glucagon and adrenaline in perfused rat liver

1986 • 29 citations

A phosphorus-31 nuclear magnetic resonance study of the metabolic, contractile, and ionic consequences of induced calcium alterations in the isovolumic rat heart.

1986 • 28 citations

Effects of work and acidosis on pyruvate dehydrogenase activity in perfused rat hearts

1980 • 27 citations

Calcium-dependent enhancement of myocardial diastolic tone and energy utilization dissociates systolic work and oxygen consumption during low sodium perfusion.

1985 • 27 citations

Relation between cytosolic free calcium and respiratory rates in cardiac myocytes

1988 • 27 citations

Ca²⁺ and Mg²⁺ as modulators of mitochondrial <scp>l</scp>‐glycerol‐3‐phosphate dehydrogenase

1988 • 26 citations

Pyruvate utilization by synaptosomes is independent of calcium

1986 • 26 citations

Pyruvate Dehydrogenase Activation after an Increase in Cardiac Output

1976 • 25 citations

Activation of pyruvate dehydrogenase by electrical stimulation, and low-Na+ perfusion of guinea-pig heart

1990 • 24 citations

Ca2+ -dependent activation of oxoglutarate dehydrogenase by vasopressin in isolated hepatocytes

1985 • 21 citations

The stimulation of tricarboxylic acid-cycle flux by α-adrenergic agonists in perfused rat liver

1986 • 19 citations

Hormone-induced intracellular calcium oscillations and mitochondrial energy supply in single hepatocytes

1990 • 19 citations

Light-induced oxygen consumption in Limulus ventral photoreceptors does not result from a rise in the intracellular sodium concentration.

1988 • 18 citations

Ca2+-binding properties of a unique ATPase inhibitor protein isolated from mitochondria of bovine heart and rat skeletal muscle

1985 • 17 citations

Glucagon treatment of rats activates the respiratory chain of liver mitochondria at more than one site

1987 • 17 citations

Hormonal regulation of the alpha-ketoglutarate dehydrogenase complex in the isolated perfused rat liver.

1988 • 16 citations

Regulation of gluconeogenesis from pyruvate and lactate in the isolated perfused rat liver

1986 • 16 citations

Adaptive changes of pyruvate oxidation in perfused heart during adrenergic stimulation

1982 • 15 citations

[Glycerin-1-phosphate and flight muscle mitochondria].

1961 • 13 citations

Role of calcium in synaptosomal substrate oxidation

1988 • 11 citations

Regulation of Respiration and Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Hepatocytes

1988 • 2 citations