Genealogy, expression, and cellular function of transforming growth factor-β

Molecular portraits of human breast tumours

2000 • 15,445 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Controlling TGF-β signaling

2000 • 1,522 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Hereditary Hemorrhagic Telangiectasia

1995 • 1,052 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1999 • 969 citations

Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

2000 • 956 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

Smads as transcriptional co-modulators

2000 • 522 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

1999 • 419 citations

Purification and initial characterization of a type beta transforming growth factor from human placenta.

1983 • 409 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Cellular transformation by coordinated action of three peptide growth factors from human platelets

1984 • 383 citations

ELEVATED LEVELS OF CIRCULATING INTERLEUKIN-6 AND TRANSFORMING GROWTH FACTOR-beta 1 IN PATIENTS WITH METASTATIC PROSTATIC CARCINOMA

1999 • 379 citations

Molecular and Cell Biology of TGF-β

1998 • 379 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis

1993 • 338 citations

Smads bind directly to the Jun family of AP-1 transcription factors

1999 • 324 citations

TGF-β receptors and actions

1994 • 291 citations

Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β

2000 • 281 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.

1998 • 249 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15^Ink4b G₁ Arrest Pathway

1999 • 224 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

Transforming growth factor-β signal transduction in epithelial cells

2001 • 194 citations

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product.

1994 • 193 citations

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

2000 • 192 citations

Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.

1998 • 189 citations

Loss of transforming growth factor β signalling in the intestine contributes to tissue injury in inflammatory bowel disease

2001 • 187 citations

A Novel Mechanism for Regulating Transforming Growth Factor β (TGF-β) Signaling

2001 • 186 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner

2001 • 180 citations

Requirement of Ras/MAPK Pathway Activation by Transforming Growth Factor β for Transforming Growth Factor β1Production in a Smad-dependent Pathway

2000 • 163 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

The MEK Pathway Is Required for Stimulation of p21WAF1/CIP1 by Transforming Growth Factor-β

1999 • 160 citations

TGF-β singaling and cancer: structural and functional consequences of mutations in Smads

1998 • 160 citations

Signal transduction by members of the transforming growth factor-β superfamily

1996 • 160 citations

Differential expression of TGF-β isoforms by normal and inflammatory bowel disease intestinal myofibroblasts

2002 • 155 citations

From transforming growth factor-β signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells

2001 • 151 citations

TGFβ in prostate cancer: A growth inhibitor that can enhance tumorigenicity

1997 • 150 citations

Identification and Characterization of an Eight-cysteine Repeat of the Latent Transforming Growth Factor-β Binding Protein-1 that Mediates Bonding to the Latent Transforming Growth Factor-β1

1996 • 143 citations

Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

1997 • 125 citations

Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.

1990 • 124 citations

Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development

1997 • 121 citations

Loss of expression of transforming growth factor beta type II receptor correlates with high tumour grade in human breast in‐situ and invasive carcinomas

2000 • 118 citations

Regulation of Endothelial Cell Growth, Architecture, and Matrix Synthesis by TGF-β

1989 • 116 citations

Transcriptional Regulation of the Transforming Growth Factor β1 Promotor by v-src Gene Products Is Mediated through the AP-1 Complex

1990 • 115 citations

Loss of Dpc4 Expression in Colonic Adenocarcinomas Correlates with the Presence of Metastatic Disease

2000 • 106 citations

Basic fibroblast growth factor and transforming growth factor beta‐1: Synergistic mediators of angiogenesis in vitro

1993 • 101 citations

c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity

2001 • 100 citations

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation

2001 • 95 citations

A Novel Type I Receptor Serine-Threonine Kinase Predominantly Expressed in the Adult Central Nervous System

1996 • 90 citations

TGF-β Receptors and Signalling Mechanisms

1998 • 86 citations

c-Jun Inhibits Transforming Growth Factor β-mediated Transcription by Repressing Smad3 Transcriptional Activity

2000 • 86 citations

Rat mesangial cell hypertrophy in response to transforming growth factor-β1

1993 • 85 citations

TGF-β isoform release and activation during in vitro bronchial epithelial wound repair

2002 • 80 citations

Regeneration of Hyaline Cartilage by Cell-Mediated Gene Therapy Using Transforming Growth Factorβ1-Producing Fibroblasts

2001 • 79 citations

Mechanism and Function of Signaling by the TGFβ Superfamily

1998 • 78 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

The Latent Transforming Growth Factor-β–binding Protein-1 Promotes In Vitro Differentiation of Embryonic Stem Cells into Endothelium

2000 • 73 citations

Transforming growth factor β1 as a biomarker for prostate cancer

1992 • 71 citations

Expression of TGF-β Signaling Genes in the Normal, Premalignant, and Malignant Human Trophoblast: Loss of Smad3 in Choriocarcinoma Cells

2001 • 70 citations

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product

1994 • 70 citations

Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex.

1990 • 66 citations

Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription.

1995 • 64 citations

Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients

1999 • 62 citations

Involvement of the Ras/MAPK Signaling Pathway in the Modulation of Urokinase Production and Cellular Invasiveness by Transforming Growth Factor-β1 in Transformed Keratinocytes

2000 • 56 citations

Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels

1996 • 56 citations

Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter.

1992 • 55 citations

Mechanisms of Transforming Growth Factor-β Receptor Endocytosis and Intracellular Sorting Differ between Fibroblasts and Epithelial Cells

2001 • 53 citations

Transgenic models for the study of prostate cancer

1993 • 49 citations

Transforming Growth Factor β Receptor Signaling and Endocytosis Are Linked through a COOH Terminal Activation Motif in the Type I Receptor

2001 • 48 citations

Differential roles of JNK and Smad2 signaling pathways in the inhibition of c-Myc-induced cell death by TGF-β

2000 • 29 citations