TGFβ in prostate cancer: A growth inhibitor that can enhance tumorigenicity

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Growth Factors and Cancer

1991 • 2,044 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Tenascin interferes with fibronectin action

1988 • 602 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Tenascin: cDNA cloning and induction by TGF-beta.

1988 • 453 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1994 • 379 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

1995 • 340 citations

Antagonistic effect of androgen on prostatic cell death

1984 • 339 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.

1992 • 242 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Effect of Transforming Growth Factor-β¹on Proliferation and Death of Rat Prostatic Cells*

1990 • 218 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

Transforming growth factor-β switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin

1989 • 199 citations

A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor

1995 • 196 citations

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

1994 • 193 citations

Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.

1993 • 192 citations

Induction of collagenase secretion in human fibroblast cultures by growth promoting factors.

1985 • 186 citations

Identification of a Cellular Receptor for Transforming Growth Factor-β in Rat Ventral Prostate and Its Negative Regulation by Androgens*

1988 • 178 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

Association of transforming growth factor-β1 with prostate cancer: An immunohistochemical study

1993 • 170 citations

Differential effects of transforming growth factor β on human prostate cancer cells in vitro

1989 • 166 citations

Transforming growth factor β stimulates mamary adenocarcinoma cell invasion and metastasis potential

1990 • 164 citations

Intron-exon structure of the human transforming growth factor-β precursor gene

1987 • 159 citations

Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.

1995 • 155 citations

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

1992 • 155 citations

Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo.

1994 • 154 citations

Excessive production of transforming growth-factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

1992 • 147 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Anti-Müllerian hormone Bruxelles: a nonsense mutation associated with the persistent Müllerian duct syndrome.

1991 • 132 citations

Expression of transforming growth factor-beta 1 in prostate cancer.

1994 • 128 citations

Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2

1995 • 128 citations

Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer

1993 • 123 citations

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.

1993 • 122 citations

Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate.

1994 • 116 citations

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

1995 • 116 citations

The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-β Receptor

1995 • 116 citations

Leiomyoma of the Kidney: Presentation of 4 New Cases and The Role of Computerized Tomography

1990 • 105 citations

cDNA cloning of porcine transforming growth factor-beta 1 mRNAs. Evidence for alternate splicing and polyadenylation.

1988 • 95 citations

A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor

1993 • 91 citations

Transforming Growth Factor-Beta: Antisense RNA-Mediated Inhibition Affects Anchorage-Independent Growth, Tumorigenicity and Tumor-Infiltrating T-Cells in Malignant Mesothelioma

1994 • 91 citations

Pleiotropic Effects of Transforming Growth Factor‐β on Cells of the Immune System

1993 • 87 citations

Reconstitution and transphosphorylation of TGF-beta receptor complexes.

1994 • 81 citations

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-β Receptors

1995 • 80 citations

Modulation of transforming growth factor beta 1 effects on prostate cancer cell proliferation by growth factors and extracellular matrix.

1995 • 78 citations

Signaling Activity of Homologous and Heterologous Transforming Growth Factor-β Receptor Kinase Complexes

1995 • 78 citations

Early cell motility changes associated with an increase in metastatic ability in rat prostatic cancer cells transfected with the v-Harvey-ras oncogene.

1988 • 75 citations

Culture systems for study of human mammary epithelial cell proliferation, differentiation and transformation.

1993 • 73 citations

Cooperative Binding of Transforming Growth Factor (TGF)-β2 to the Types I and II TGF-β Receptors

1995 • 73 citations

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

1994 • 71 citations

Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.

1994 • 66 citations

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients.

1995 • 65 citations

Growth inhibition of transforming growth factor beta on human gastric carcinoma cells: receptor and postreceptor signaling.

1992 • 61 citations

Increased tumorigenicity in the human pancreatic cell line MIA PaCa‐2 Is associated with an aberrant regulation of an IGF‐1 autocrine loop and lack of expression of the TGF‐β type RII receptor

1995 • 58 citations

Mapping the Domain(s) Critical for the Binding of Human Tumor Necrosis Factor-α to Its Two Receptors

1995 • 57 citations

A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands.

1994 • 54 citations

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal Transduction

1995 • 53 citations

Structural and Sequence Analysis of TGF-β2 cDNA Clones Predicts Two Different Precursor Proteins Produced by Alternative mRNA Splicing

1988 • 53 citations

Positive and negative controls on cell growth

1989 • 46 citations

Nonpolarized Distribution of Glycosylphosphatidylinositols in the Plasma Membrane of Polarized Madin-Darby Canine Kidney Cells

1995 • 46 citations

Cloning of an isoform of mouse TGF‐β type II receptor gene

1994 • 40 citations

Induction of transforming growth factor beta in hormonally treated human prostate cancer

1994 • 36 citations

Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

1994 • 35 citations

Colon Cancer Cells That Are Not Growth Inhibited by TGF-β Lack Functional Type I and Type II TGF-β Receptors

1995 • 32 citations

Rat Prostate Cancer Cells Contain Functional Receptors for Transforming Growth Factorβ*

1990 • 31 citations

[Ser77]transforming growth factor-beta 1. Selective biological activity and receptor binding in mink lung epithelial cells.

1994 • 30 citations

A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways.

1993 • 30 citations

Transforming growth factor‐β receptor expression on endothelial cells: Heterogeneity of type III receptor expression

1995 • 26 citations

Effects of Transforming Growth Factor β1 on the Adenylyl Cyclase-cAMP Pathway in Prostate Cancer

1994 • 15 citations