Transgenic models for the study of prostate cancer

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

Cancer statistics, 1991

1991 • 625 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

1990 • 398 citations

Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes.

1989 • 378 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

The prostate: An increasing medical problem

1990 • 356 citations

Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

1990 • 342 citations

Epithelial-mesenchymal interactions in prostatic development. I. morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder.

1983 • 289 citations

Transforming growth factor-β: Multiple effects on cell differentiation and extracellular matrices

1988 • 271 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Clinical Evidence for and Implications of the Multistep Development of Prostate Cancer

1990 • 256 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Early Detection of Prostate Cancer

1989 • 208 citations

Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β

1990 • 203 citations

Increased expression of genes for basic fibroblast growth factor and transforming growth factor type β2 in human benign prostatic hyperplasia

1990 • 181 citations

Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl)retinamide.

1991 • 178 citations

Frequency and pattern of karyotypic abnormalities in human prostate cancer.

1990 • 172 citations

Association of transforming growth factor-β1 with prostate cancer: An immunohistochemical study

1993 • 170 citations

Transforming growth factor β stimulates mamary adenocarcinoma cell invasion and metastasis potential

1990 • 164 citations

Epidemiologic evidence regarding predisposing factors to prostate cancer

1990 • 149 citations

Role of transforming growth factor ‐α in human prostate cancer cell growth

1989 • 142 citations

Growth factors and oncogenes in prostate cancer.

1990 • 115 citations

Prostatic growth factor: purification and structural relationship to basic fibroblast growth factor

1987 • 105 citations

The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice

1987 • 100 citations

Epithelial-mesenchymal interactions in prostatic development. II. Biochemical observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder.

1983 • 91 citations

Natural History of Low-Stage Prostatic Cancer and the Impact of Early Detection

1990 • 82 citations

Expression of basic fibroblast growth factor mRNA in benign prostatic hyperplasia and prostatic carcinoma

1988 • 80 citations

Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland

1988 • 75 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Elevated Transforming Growth Factor-β 1 and β3 mRNA Levels are Associated withras+myc-induced Carcinomas in Reconstituted Mouse Prostate: Evidence for a Paracrine Role during Progression

1991 • 62 citations

Heparin‐binding growth factor isolated from human prostatic extracts

1988 • 53 citations

Restriction of neuroblastoma to the prostate gland in transgenic mice.

1991 • 42 citations

Growth factors and their receptors in differentiation and early murine development

1990 • 39 citations

Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.

1986 • 37 citations

Androgen-regulated expression of secretory protein synthesis in mouse ventral prostate

1987 • 37 citations

Androgen-induced biochemical responses in epithelium lacking androgen receptors: Characterization of androgen receptors in the mesenchymal derivative of urogenital sinus

1986 • 34 citations

Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2.

1989 • 33 citations

Rat Prostate Cancer Cells Contain Functional Receptors for Transforming Growth Factorβ*

1990 • 31 citations