TGF-β Receptors and Signalling Mechanisms

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

The No Apical Meristem Gene of Petunia Is Required for Pattern Formation in Embryos and Flowers and Is Expressed at Meristem and Primordia Boundaries

1996 • 984 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor

1996 • 457 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Activation of Signalling by the Activin Receptor Complex

1996 • 317 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

1996 • 285 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor

1994 • 254 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

1996 • 245 citations

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

1996 • 242 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye

1996 • 223 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family

1995 • 212 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

1997 • 203 citations

schnurri is required for drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1

1995 • 200 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells

1996 • 174 citations

Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor

1996 • 172 citations

Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway

1997 • 168 citations

Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins

1996 • 162 citations

Signal transduction by members of the transforming growth factor-β superfamily

1996 • 160 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

1996 • 146 citations

Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.

1996 • 132 citations

A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

1997 • 129 citations

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β

1996 • 125 citations

Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

1997 • 125 citations

A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling

1995 • 125 citations

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1996 • 120 citations

The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-β Receptor

1995 • 116 citations

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

1995 • 116 citations

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

1995 • 110 citations

Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human

1996 • 89 citations

Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade

1997 • 88 citations

Genetics business booming yet uncertain

1994 • 5 citations