Loss of Dpc4 Expression in Colonic Adenocarcinomas Correlates with the Presence of Metastatic Disease

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

1987 • 683 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.

2000 • 574 citations

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1999 • 430 citations

Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas

2000 • 296 citations

Frequency of Smad gene mutations in human cancers.

1997 • 289 citations

Homozygous deletion map at 18q21.1 in pancreatic cancer.

1996 • 269 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

Prognosis of node-positive colon cancer

1991 • 172 citations

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

1999 • 168 citations

Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases

1998 • 144 citations

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

1997 • 126 citations

Frequent 4-bp deletion in exon 9 of theSMAD4/MADH4 gene in familial juvenile polyposis patients

1999 • 98 citations

Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.

1996 • 91 citations

Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 87 citations

Inactivation of Smad4 in gastric carcinomas.

1997 • 68 citations

Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.

1996 • 66 citations

DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination

2000 • 63 citations

Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients

1999 • 62 citations

DPC4 gene mutation in colitis associated neoplasia.

1997 • 56 citations

Orthotopic Models of Human Pancreatic Cancer

1999 • 53 citations

Intracellular Signaling of the TGF‐β Superfamily by Smad Proteins

1999 • 52 citations

Tumor-Suppressor genes in pancreatic cancer

1998 • 48 citations

MAD‐related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma

1997 • 33 citations

Involvement of mutations in theDPC4 promoter in endometrial carcinoma development

1999 • 28 citations

Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas

1999 • 26 citations

Cancer gets Mad: DPC4 and other TGFβ pathway genes in human cancer

1996 • 24 citations

SMAD4 Germline Mutations in Juvenile Polyposis Coli

1999 • 10 citations

Frequent Allelic Imbalance on Chromosome 18q21 in Early Superficial Colorectal Cancers

1999 • 9 citations