The MEK Pathway Is Required for Stimulation of p21WAF1/CIP1 by Transforming Growth Factor-β

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1998 • 348 citations

Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

1997 • 301 citations

Smad2 transduces common signals from receptor serine–threonine and tyrosine kinases

1998 • 291 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1997 • 229 citations

Activation of p21ras by transforming growth factor beta in epithelial cells.

1992 • 223 citations

TGF-β–induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein

1998 • 211 citations

Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

1997 • 175 citations

Role of p300, a transcriptional coactivator, in signalling of TGF‐β

1998 • 162 citations

Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation

1999 • 142 citations

p21^WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA

1998 • 138 citations

Molecular Mechanisms of Transforming Growth Factor-β Signaling

1998 • 135 citations

Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells

1999 • 132 citations

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

1999 • 120 citations

Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-β

1998 • 118 citations

Sp1, but not Sp3, functions to mediate promoter activation by TGF- through canonical Sp1 binding sites

1998 • 99 citations

Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

1998 • 86 citations

TGFβ regulation of mitogen-activated protein kinases in human breast cancer cells

1997 • 68 citations

UV Radiation Is a Transcriptional Inducer of p21Cip1/Waf1Cyclin-Kinase Inhibitor in a p53-Independent Manner

1999 • 56 citations

Blockade of TGFβ3 up-regulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells

1998 • 37 citations

The Mycotoxin Fumonisin B1 Transcriptionally Activates the p21 Promoter through acis-Acting Element Containing Two Sp1 Binding Sites

1999 • 19 citations