Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Fossils, genes and the evolution of animal limbs

1997 • 796 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Molecular Models for Vertebrate Limb Development

1997 • 592 citations

Analysis of Hox gene expression in the chick limb bud

1996 • 480 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Hox gene expression in teleost fins and the origin of vertebrate digits

1995 • 315 citations

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

1985 • 294 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

Gene Transpositions in the HoxD Complex Reveal a Hierarchy of Regulatory Controls

1996 • 226 citations

Hox9 genes and vertebrate limb specification

1997 • 214 citations

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth

1997 • 208 citations

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene

1990 • 201 citations

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development

1997 • 199 citations

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice

1997 • 196 citations

A duplicated zone of polarizing activity in polydactylous mouse mutants.

1995 • 189 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.

1967 • 172 citations

Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt)

1992 • 164 citations

Limbs: a model for pattern formation within the vertebrate body plan

1996 • 155 citations

Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice

1997 • 152 citations

Vertebrate Hox genes and proliferation: an alternative pathway to homeosis?

1995 • 141 citations

The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning

1997 • 139 citations

Mutations in mouseAristaless-like4causeStrong’s luxoidpolydactyly

1998 • 136 citations

Retinoic acid signaling is required during early chick limb development

1996 • 132 citations

Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop

1997 • 131 citations

Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain- of-function of posterior Hoxd genes

1997 • 120 citations

The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions

1996 • 116 citations

Multigenic Control of the Localization of the Zone of Polarizing Activity in Limb Morphogenesis in the Mouse

1997 • 115 citations

Fins, limbs, and tails: outgrowths and axial patterning in vertebrate evolution

1998 • 112 citations

Disruption of formin-encoding transcripts in two mutant limb deformity alleles

1990 • 110 citations

Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation

1997 • 109 citations

The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation

1996 • 103 citations

Strike three for GLI3

1997 • 93 citations

The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation.

1989 • 78 citations

Control of Colinearity in AbdB Genes of the Mouse HoxD Complex

1998 • 78 citations

The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′ HoxD genes during limb pattern formation

1995 • 72 citations

Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of gf-4 and shh in the limb bud

1995 • 67 citations

The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo

1991 • 65 citations

The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis.

1992 • 63 citations

Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb

1997 • 58 citations

Dorso‐ventral limb polarity and origin of the ridge: On the fringe of independence?

1997 • 48 citations

A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm

1997 • 48 citations

Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge

1997 • 45 citations

Limb mutants: what can they tell us about normal limb development?

1997 • 41 citations

Genetic Evidence That Formins Function within the Nucleus

1996 • 39 citations

The Role of a Single Formin Isoform in the Limb and Renal Phenotypes of Limb Deformity

1997 • 39 citations

Polydactyly in theStrong's luxoid mouse is suppressed bylimb deformity alleles

1996 • 10 citations