Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Hox genes in vertebrate development

1994 • 2,057 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

A distinct Hox code for the branchial region of the vertebrate head

1991 • 503 citations

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

1993 • 469 citations

Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity

1992 • 461 citations

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1993 • 452 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

The regulation of myogenin gene expression during the embryonic development of the mouse.

1993 • 419 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

1995 • 396 citations

Two rhombomeres are altered in Hoxa-1 mutant mice

1993 • 391 citations

The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein

1994 • 378 citations

Induction across germ layers in Drosophila mediated by a genetic cascade

1990 • 342 citations

Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain

1993 • 340 citations

The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation

1993 • 297 citations

Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.

1991 • 286 citations

Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1

1994 • 281 citations

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

1991 • 280 citations

extradenticle Raises the DNA binding specificity of homeotic selector gene products

1994 • 269 citations

Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos

1990 • 265 citations

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1

1993 • 264 citations

Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

1990 • 239 citations

Autoregulation of a drosophila homeotic selector gene

1988 • 229 citations

The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

1994 • 207 citations

Homeotic genes and positional signalling in the Drosophila viscera

1994 • 180 citations

Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis

1994 • 180 citations

Hox Genes and Regionalization of the Nervous System

1994 • 172 citations

EctopicHoxa-1induces rhombomere transformation in mouse hindbrain

1994 • 166 citations

Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.

1994 • 157 citations

Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization

1993 • 153 citations

Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia.

1993 • 138 citations

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

1994 • 135 citations

Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development.

1989 • 132 citations

Silencers in abdominal-B, a homeotic Drosophila gene.

1993 • 130 citations

Homeotic gene expression in the visceral mesoderm of Drosophila embryos.

1989 • 128 citations

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.

1994 • 123 citations

Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction.

1995 • 122 citations

A homeo domain protein reveals the metameric nature of the developing chick hindbrain.

1990 • 118 citations

PBX2 and PBX3, New Homeobox Genes with Extensive Homology to the Human Proto-Oncogene PBX1

1991 • 108 citations

High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.

1991 • 99 citations

Specification of a single cell type by a Drosophila homeotic gene

1994 • 96 citations

Expression Patterns of Hoxb Genes in the Xenopus Embryo Suggest Roles in Anteroposterior Specification of the Hindbrain and in Dorsoventral Patterning of the Mesoderm

1994 • 96 citations

Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation

1992 • 87 citations

Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster. evidence for both positive and negative autogenous regulation

1991 • 84 citations

Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm.

1995 • 84 citations

Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos.

1994 • 72 citations

Dissection of an indirect autoregulatory response of a homeotic Drosophila gene.

1993 • 66 citations

Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system

1992 • 59 citations

Dpbx, a new homeobox gene closely related to the human proto-oncogene pbxl molecular structure and developmental expression

1993 • 58 citations

Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm.

1994 • 43 citations