Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

1993 • 1,083 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Early stages of chick somite development

1995 • 781 citations

Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation

1996 • 774 citations

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

1993 • 617 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation

1993 • 502 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

A homeobox gene essential for zebrafish notochord development

1995 • 462 citations

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

1994 • 451 citations

Midline signalling is required for Pax gene regulation and patterning of the eyes

1995 • 433 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

Induction of a second neural axis by the mouse node

1994 • 420 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

Expression pattern of the Brachyury gene in whole-mount T WIS/T WIS mutant embryos

1991 • 350 citations

The role of Pax-1 in axial skeleton development

1994 • 343 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Characterization and Developmental Expression of Pax9, a Paired-Box-Containing Gene Related to Pax1

1995 • 263 citations

How is myogenesis initiated in the embryo?

1996 • 231 citations

The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation

1992 • 216 citations

The T genes in embryogenesis

1994 • 215 citations

Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis

1995 • 200 citations

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

1995 • 198 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Limbs: a model for pattern formation within the vertebrate body plan

1996 • 155 citations

Emx and Otx homeobox genes in the developing mouse brain

1993 • 139 citations

Local signalling in dermomyotomal cell type specification

1992 • 129 citations

Restrictions to Floor Plate Induction by hedgehog and Winged-Helix Genes in the Neural Tube of Frog Embryos

1995 • 107 citations

Pax proteins and eye development

1996 • 86 citations

Pax genes in development

1994 • 73 citations

A molecular approach to the evolution of vertebrate paired appendages

1996 • 68 citations

Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage

1995 • 64 citations

The Problem of Cyclopia. Part II

1936 • 53 citations

Control of maintenance and anteroposterior skeletal differentiation of the anterior mesenchyme of the chick wing bud by its posterior margin (the ZPA)

1981 • 44 citations

Holoprosencephaly and septo-optic dysplasia.

1994 • 36 citations