A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

Wnt genes

1992 • 799 citations

Cloning of the zebrafishkrox-20gene (krx-20) and its expression during hindbrain development

1993 • 708 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene

1994 • 628 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

The pathway to signal achievement

1993 • 563 citations

Vectors for Drosophila P-element-mediated transformation and tissue culture transfection

1988 • 547 citations

Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation

1993 • 502 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish

1993 • 458 citations

Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis

1991 • 443 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 406 citations

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein

1985 • 406 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 308 citations

Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord

1990 • 300 citations

Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos

1994 • 294 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.

1993 • 283 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

Active repression of transcription by the engrailed homeodomain protein.

1991 • 248 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Boundaries and fields in early embryos

1992 • 239 citations

Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.

1988 • 190 citations

Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched

1990 • 182 citations

Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate

1991 • 177 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Genetic analysis of hedgehog signalling in the Drosophila embryo

1993 • 167 citations

Regulation of wingless transcription in the Drososphila embryo

1993 • 135 citations

The Wnt family of developmental regulators

1992 • 121 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo

1989 • 103 citations

Essential Developmental Biology: A Practical Approach

1994 • 100 citations

Midline signaling in the primordium of the zebrafish anterior central nervous system.

1994 • 98 citations

Mesoderm-inducing factors: a small class of molecules

1988 • 98 citations

Structure and expression of Hedgehog, a Drosophila segment-polarity gene required for cell-cell communication

1993 • 93 citations

Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis.

1993 • 87 citations

Segment polarity genes and cell patterning within the Drosophila body segment

1991 • 81 citations

Midline cells and the organization of the vertebrate neuraxis

1993 • 43 citations