Gene Transpositions in the HoxD Complex Reveal a Hierarchy of Regulatory Controls

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Hox genes in vertebrate development

1994 • 2,057 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

1994 • 775 citations

Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony

1994 • 631 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

1995 • 587 citations

Gene targeting: a practical approach.

1993 • 585 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Colinearity and functional hierarchy among genes of the homeotic complexes

1994 • 450 citations

Imprinting a determined state into the chromatin of Drosophila

1990 • 391 citations

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

1991 • 344 citations

THE BITHORAX COMPLEX

1987 • 326 citations

Differential Staining of Cartilage and Bone in Fetal Mouse Skeleton by Alcian Blue and Alizarin Red S

1976 • 323 citations

Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products

1993 • 317 citations

Hox gene expression in teleost fins and the origin of vertebrate digits

1995 • 315 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

HOX-4 genes and the morphogenesis of mammalian genitalia.

1991 • 292 citations

Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.

1991 • 286 citations

Spatially restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan

1988 • 245 citations

Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds.

1995 • 205 citations

The bithorax complex: control of segmental identity

1987 • 188 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications

1995 • 160 citations

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

1995 • 155 citations

Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation

1987 • 137 citations

The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

1991 • 135 citations

The mouse has a Polycomb-Wke chromobox gene

1992 • 135 citations

How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres

1995 • 125 citations

Spatial regulation of homeobox gene fusions in the embryonic central nervous system of transgenic mice

1988 • 113 citations

Separate elements cause lineage restriction and specify boundaries of Hox-1·1 expression

1991 • 105 citations

Two Phases in the Establishment of HOX Expression Domains

1993 • 105 citations

Homeogene expression patterns and chromosomal imprinting.

1990 • 104 citations

Function of the Polycomb protein is conserved in mice and flies

1995 • 100 citations

Retinoic acid and homeobox gene regulation

1994 • 96 citations

Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex

1996 • 93 citations

Expression patterns of mouse hox genes: Clues to an understanding of developmental and evolutionary strategies

1991 • 92 citations

Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation.

1993 • 75 citations

A molecular approach to the evolution of vertebrate paired appendages

1996 • 68 citations

Colinearity in the Xenopus laevis Hox-2 complex

1993 • 68 citations

Forward spreading in the establishment of a vertebrate Hox expression boundary: The expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers

1994 • 67 citations

Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4.

1992 • 65 citations

Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex

1994 • 51 citations

Plant growth and development: A molecular approach

1995 • 3 citations