Antioxidant-Inducible Genes

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Chemoprevention of Cancer

2008 • 1,269 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

1988 • 753 citations

Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules

1981 • 733 citations

Genetic Risk and Carcinogen Exposure: a Common Inherited Defect of the Carcinogen-Metabolism Gene Glutathione S-Transferase M1 (GSTM1) That Increases Susceptibility to Bladder Cancer

1993 • 709 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

Enzyme induction in the cytochrome P-450 system

1990 • 631 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Glutathione Transferases and Cancer

1992 • 548 citations

DT-diaphorase as a quinone reductase: A cellular control device against semiquinone and superoxide radical formation

1982 • 530 citations

[Chemoprevention of cancer].

1986 • 524 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

1991 • 499 citations

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

1990 • 472 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

The serum response element

1992 • 458 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Glutathione, ascorbate, and cellular protection.

1994 • 434 citations

Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

1993 • 431 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun.

1994 • 418 citations

Differential regulation of antioxidant enzymes in response to oxidants.

1991 • 411 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

Aldehyde Dehydrogenases and Their Role in Carcinogenesis

1992 • 400 citations

Antimutagenesis and Anticarcinogenesis Mechanisms

1986 • 378 citations

Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and of two H-chain deletion mutants.

1988 • 366 citations

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

1992 • 353 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

1978 • 338 citations

One-electron-transfer reactions in biochemical systems V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

1970 • 335 citations

UDP-glucuronosyltransferases

1989 • 327 citations

[30] DT-diaphorase: Purification, properties, and function

1990 • 316 citations

Regulation of the transcription factors NF-κB and AP-1 by redox changes

1994 • 310 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

The UDP Glucuronosyltransferase Gene Super family: Suggested Nomenclature Based on Evolutionary Divergence

1991 • 275 citations

Metabolic activation of carcinogens

1992 • 271 citations

Screening of potential chemopreventive agents using biochemical markers of carcinogenesis.

1994 • 271 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

UDP-glucuronosyltransferases: a family of detoxifying enzymes

1990 • 256 citations

Antioxidant response element

1994 • 245 citations

Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum

1991 • 242 citations

Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

1987 • 242 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

UDP-glucur-onosyltransferases

1989 • 240 citations

The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung

1993 • 237 citations

Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital.

1984 • 235 citations

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

1992 • 230 citations

Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.

1981 • 230 citations

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

1989 • 226 citations

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

1995 • 222 citations

Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

1984 • 213 citations

Liver response tests. III. Liver enlargement and stimulation of microsomal processing enzyme activity

1965 • 211 citations

Reduction in glutathione content of L-PAM resistant L1210 cells confers drug sensitivity

1982 • 205 citations

Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

1979 • 200 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases

1992 • 190 citations

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

1995 • 189 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Identification of a Putative Antioxidant Response Element in the 5′-Flanking Region of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1995 • 187 citations

Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

1995 • 185 citations

The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma.

1993 • 176 citations

Microsomal epoxide hydrolase properties, regulation and function

1983 • 168 citations

Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study.

1994 • 168 citations

Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.

1991 • 162 citations

Biochemical effects of dithiolthiones

1986 • 161 citations

The Ferritin Family of Iron Storage Proteins

1990 • 157 citations

Multiple regulatory elements and phorbol 12-O-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene.

1988 • 154 citations

Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.

1995 • 154 citations

Structural and functional analysis of an enhancer GPEI having a phorbol 12-O-tetradecanoate 13-acetate responsive element-like sequence found in the rat glutathione transferase P gene

1989 • 154 citations

A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.

1994 • 153 citations

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1994 • 152 citations

Modification of aflatoxin B₁ binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione

1985 • 150 citations

Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

1991 • 148 citations

Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithioI-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard

1986 • 144 citations

Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones

1994 • 144 citations

ARE- and TRE-mediated Regulation of Gene Expression

1995 • 140 citations

Reduction of a conserved Cys is essential for Myb DNA-binding

1992 • 129 citations

An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.

1993 • 127 citations

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

1992 • 127 citations

Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA.

1983 • 124 citations

Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism.

1988 • 122 citations

Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.

1990 • 117 citations

Metabolism of benzo(a)pyrene-3,6-quinone and 3-hydroxybenzo(a)pyrene in liver microsomes from 3-methylcholanthrene-treated rats

1978 • 115 citations

Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.

1993 • 110 citations

Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin.

1993 • 110 citations

Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.

1995 • 106 citations

Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.

1979 • 105 citations

Glutathione conjugation

1989 • 101 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.

1993 • 100 citations

Temporary decrease in renal quinone reductase activity induced by chronic administration of estradiol to male Syrian hamsters. Increased superoxide formation by redox cycling of estrogen.

1988 • 100 citations

Effect of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in mice

1979 • 99 citations

Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer l,2-dithiole-3-thione

1992 • 98 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.

1995 • 97 citations

Rat liver aldehyde dehydrogenase. II. Isolation and characterization of four inducible isozymes.

1984 • 97 citations

Functional cooperativity between two TPA responsive elements in undifferentiated F9 embryonic stem cells.

1990 • 97 citations

Regulation of rat glutathione S-transferase Ya subunit gene expression. DNA-protein interaction at the antioxidant responsive element.

1992 • 96 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

Phenobarbital-inducible Aldehyde Dehydrogenase in the Rat

1989 • 93 citations

Involvement of NF-κB in the induction of NAD(P)H: Quinone oxidoreductase (DT-diaphorase) by hypoxia, oltipraz and mitomycin C

1995 • 89 citations

Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism

1993 • 88 citations

Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance

1987 • 88 citations

Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.

1990 • 87 citations

A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant

1993 • 87 citations

Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.

1978 • 83 citations

Reduction of benzo(a)pyrene mutagenicity by dihydrodiol dehydrogenase

1979 • 83 citations

Oltipraz: Clinical opportunities for cancer chemoprevention

1995 • 83 citations

NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation.

1986 • 82 citations

Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.

1990 • 81 citations

Role of Quinone-Mediated Generation of Hydroxyl Radicals in the Induction of Glutathione S-Transferase Gene Expression

1995 • 80 citations

Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.

1992 • 80 citations

Role of cytochrome P₁ in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants

1987 • 80 citations

Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer.

1995 • 80 citations

Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole.

1988 • 78 citations

Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter.

1990 • 77 citations

Elevation of quinone reductase activity by anticarcinogenic antioxidants

1982 • 75 citations

Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression

1993 • 74 citations

Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1.

1994 • 72 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants.

1993 • 72 citations

Cellular glutathione as a determinant of sensitivity to mercuric chloride toxicity

1990 • 71 citations

Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.

1994 • 70 citations

Modulation of γ-Glutamylcysteine Synthetase Large Subunit mRNA Expression by Butylated Hydroxyanisole

1994 • 66 citations

Cancer Biology and Therapeutics

1987 • 66 citations

Prevention of benzo(a)pyrene‐induced mutagenicity by homogeneous epoxide hydratase

1976 • 63 citations

Structure and organization of the microsomal xenobiotic epoxide hydrolase gene.

1987 • 62 citations

Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.

1995 • 61 citations

Cellular and molecular targets for chemoprevention

1993 • 61 citations

Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs.

1985 • 55 citations

The Ferritin Genes: Their Response to Iron Status

2009 • 54 citations

Effects of butylated hydroxytoluene on the enzyme activity and ultrastructure of rat hepatocytes

1970 • 54 citations

Mouse Glutathione S-Transferase Ya Subunit: Gene Structure and Sequence

1987 • 53 citations

Molecular Mechanisms in Protection Against Carcinogenesis

1987 • 53 citations

In vitro and in vivo biotransformation and covalent binding of benzo(a)pyrene in Gunn and RHA rats with a genetic deficiency in bilirubin uridine diphosphate-glucuronosyltransferase.

1992 • 51 citations

Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones

1993 • 51 citations

Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein.

1987 • 49 citations

Detection of a nuclear protein which binds specifically to the antioxidant responsive element (ARE) of the human NAD(P)H:quinone oxidoreductase gene

1994 • 48 citations

Promoter-glutathione S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells.

1987 • 48 citations

Effect of phenobarbital and 3-methylcholanthrene administration on epoxide hydrase levels in liver microsomes

1977 • 48 citations

Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz

1995 • 47 citations

Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes

1977 • 47 citations

Rat and human microsomal epoxide hydratase. Immunological characterization of various forms of the enzyme.

1979 • 47 citations

1, 2-Dithiol-3-thione analogs: effects on NAD(P)H: quinone reductase and glutathione levels in murine hepatoma cells

1986 • 46 citations

Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas.

1995 • 46 citations

Induction of DT-Diaphorase by Anticarcinogenic Sulfur Compounds in Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1986 • 45 citations

Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression

1994 • 43 citations

Suppression of rat glutathione transferase P expression by peroxisome proliferators: interaction between Jun and peroxisome proliferator-activated receptor alpha.

1995 • 43 citations

Increase in γ-Glutamylcysteine Synthetase Activity as a Mechanism for Butylated Hydroxyanisole-Mediated Elevation of Hepatic Glutathione

1994 • 43 citations

Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity.

1988 • 42 citations

Identification of a methylcholanthrene-induced aldehyde dehydrogenase in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.

1994 • 41 citations

Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance

1995 • 41 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants

1993 • 40 citations

Carcinogen-induced drug resistance in rat hepatocytes.

1981 • 40 citations

Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver

1992 • 35 citations

Coordinate induction of glutathione S-transferase alpha, mu, and pi expression in murine liver after a single administration of oltipraz.

1994 • 35 citations

Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex

1992 • 35 citations

DT-diaphorase activity and the cytotoxicity of quinones in C3H/10T1/2 mouse embryo cells

1988 • 32 citations

Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.

1993 • 31 citations

Purification of an alpha class glutathione S-transferase from melphalan-resistant Chinese hamster ovary cells and demonstration of its ability to catalyze melphalan-glutathione adduct formation.

1994 • 29 citations

Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase

1992 • 29 citations

Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol

1992 • 28 citations

Reversibility of hepatic changes caused by ethoxyquin

1974 • 26 citations

Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix

1991 • 24 citations

tert-Butyl-4-hydroxyanisole

1998 • 22 citations

Structure and Tissue-Specific Expression of the Aldo-Keto Reductase Superfamily

1994 • 21 citations

Regulation of uridine diphosphate glucuronosyltransferase expression by phenolic antioxidants.

1994 • 20 citations

Inhibition of some rat hepatic microsomal enzymes by ethoxyquin

1974 • 19 citations

Chemoprotection by Inducers of Electrophile Detoxication Enzymes

1993 • 18 citations

Toxic effects of daunorubicin on isolated and cultured heart cells from neonatal rats

1985 • 18 citations

Glucocorticoid repression and basal regulation of the epoxide hydrolase promoter

1990 • 17 citations

Contribution of dihydrodiol dehydrogenase to the metabolism of (±)-trans;-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions

1992 • 16 citations

Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice.

1989 • 11 citations

The genesis of cancer with chemicals.

1980 • 10 citations