Role of Quinone-Mediated Generation of Hydroxyl Radicals in the Induction of Glutathione S-Transferase Gene Expression

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Oxidative stress: From basic research to clinical application

1991 • 1,302 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

1991 • 499 citations

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

1990 • 472 citations

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1991 • 468 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

Free radical formation by antitumor quinones

1989 • 419 citations

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

1992 • 353 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

Glutathione S-Transferases: Gene Structure and Regulation of Expression

1993 • 300 citations

Redox control of enzyme activities by thiol/disulfide exchange

1984 • 264 citations

[8] Chemical depletion of glutathione in vivo

1981 • 242 citations

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

1992 • 230 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1992 • 212 citations

[9] Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo

1990 • 195 citations

Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene.

1992 • 194 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

1992 • 179 citations

Multiple regulatory elements and phorbol 12-O-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene.

1988 • 154 citations

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

1989 • 128 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

Quantitative determination of SH groups in low- and high-molecular-weight compounds by an electron spin resonance method

1989 • 89 citations

Enhancement of glutathione levels in mouse peritoneal macrophages by sodium arsenite, cadmium chloride and glucose/glucose oxidase

1991 • 87 citations

Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression

1993 • 74 citations

Role of quinone-iron(III) interaction in NADPH-dependent enzymic generation of hydroxyl radicals

1992 • 46 citations

Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression

1994 • 43 citations

[66] Modulation of cellular glutathione and protein thiol status during quinone metabolism

1990 • 40 citations

EPR method for the measurement of cellular sulfhydryl groups

1991 • 35 citations

[8] Oxygen radicals generation and DNA scission by anticancer and synthetic quinones

1994 • 30 citations

When will enough be enough?

1993 • 7 citations

Elevation of glutathione and γ-glutamyl cycle enzyme activities and mRNA by naphthoquinones

1993 • 2 citations

Cystine transport induction is an oxidant stress response in endothelial cells

1993 • 1 citations

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