Chemoprotection by Inducers of Electrophile Detoxication Enzymes

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Chemoprevention of Cancer

2008 • 1,269 citations

Bioactivation of foreign compounds

1985 • 733 citations

Down-Regulation of the Antitumor Immune Response

1985 • 676 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

1990 • 472 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer

1986 • 382 citations

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

1978 • 338 citations

Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview

1988 • 290 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

1987 • 242 citations

Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

1979 • 200 citations

Primary liver cancer

1989 • 187 citations

Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.

1991 • 162 citations

Modification of aflatoxin B₁ binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione

1985 • 150 citations

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.

1990 • 148 citations

Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA.

1983 • 124 citations

Dose-related inhibition of aflatoxin B₁ induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene

1986 • 113 citations

Organization and function of a dioxin-responsive enhancer.

1990 • 99 citations

Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.

1990 • 87 citations

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

1991 • 84 citations

The inhibitory effects of ethoxyquin on the carcinogenic action of aflatoxin B1 in rats

1983 • 82 citations

Role of cytochrome P₁ in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants

1987 • 80 citations

Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole.

1988 • 78 citations

The antischistosomal activity of oltipraz.

1982 • 75 citations

Chemoprevention clinical trials

1992 • 52 citations

Promoter-glutathione S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells.

1987 • 48 citations

Specificity of induction of cancer protective enzymes by analogues of tert-butyl-4-hydroxyanisole (BHA)

1985 • 37 citations

Kinetics of glutathione transferase, glutathione transferase messenger RNA, and reduced nicotinamide adenine dinucleotide (phosphate):quinone reductase induction by 2(3)-tert-butyl-4-hydroxyanisole in mice.

1984 • 27 citations

Cancer Chemopreventive Agents

1993 • 10 citations

Effect of 1,2-dithiole-3-thione, a monofunctional enzyme inducer, on aflatoxin-DNA adduct formation in rat liver.

1990 • 5 citations