Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

HEREDITARY ACHOLURIC JAUNDICE

1938 • 331 citations

The UDP Glucuronosyltransferase Gene Super family: Suggested Nomenclature Based on Evolutionary Divergence

1991 • 275 citations

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

1991 • 261 citations

Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome

1992 • 162 citations

The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a −1 frameshift mutation

1989 • 108 citations

Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: Possible alternate splicing of a common primary transcript

1990 • 79 citations

The glucuronosyltransferases: What progress can pharmacologists expect from molecular biology and cellular enzymology?

1987 • 69 citations

Glucuronidation and biliary excretion of acetaminophen in rats.

1984 • 63 citations

Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency

1989 • 50 citations

Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity.

1988 • 42 citations

Genetic defect of bilirubin UDP-glucuronosyltransferase in the hyperbilirubinemic Gunn rat

1991 • 38 citations

Differences in udp-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundice locus

1983 • 37 citations

Age-related increased susceptibility of male Fischer 344 rats to acetaminophen nephrotoxicity

1986 • 26 citations

Hepatic UDP-glucuronic acid regulation during acetaminophen biotransformation in rats.

1986 • 25 citations

Role of UDPGA flux in acetaminophen clearance and hepatotoxicity

1984 • 25 citations

Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronyltransferases by cross-breeding of two mutant rat strains

1988 • 18 citations

The development of acetaminophen-induced nephrotoxicity in male Fischer 344 rats of different ages

1986 • 14 citations

Repetitive Microvolumetric Sampling and Analysis of Acetaminophen and its Toxicologically Relevant Metabolites in Murine Plasma and Urine Using High Performance Liquid Chromatography

1985 • 14 citations

Murine acetaminophen hepatotoxicity: Temporal interanimal variability in plasma glutamic-pyruvic transaminase profiles and relation to in vivo chemical covalent binding*1

1986 • 9 citations