Microsomal epoxide hydrolase properties, regulation and function

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Arene Oxides: A New Aspect of Drug Metabolism

1974 • 1,043 citations

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Chemical Carcinogenesis

1975 • 741 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

The Biosynthesis of Mitochondrial Proteins

1974 • 739 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Benzo[ a ]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in Vitro and in Vivo

1976 • 584 citations

An enzyme from rat liver catalysing conjugations with glutathione

1961 • 563 citations

Microsomes, Drug Oxidations and Chemical Carcinogenesis

1980 • 498 citations

1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. V

1970 • 428 citations

A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide

1971 • 414 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Structural aspects of the membrane of the endoplasmic reticulum

1975 • 351 citations

A microsome-dependent binding of benzo[a]pyrene to DNA.

1969 • 332 citations

Polynuclear aromatic hydrocarbons

1984 • 325 citations

Hepatic epoxide hydrase. Structure-activity relations for substrates and inhibitors

1971 • 316 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

1973 • 315 citations

Conjugation Reactions in Drug Biotransformation

1980 • 314 citations

The Molecular Biology of Cancer

1974 • 298 citations

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

1976 • 274 citations

Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro

1968 • 261 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 245 citations

Enzymatic Conjugation of Epoxides with Glutathione

1973 • 237 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

1976 • 232 citations

The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes

1968 • 222 citations

Inhibition of cell growth by oxygenated derivatives of cholesterol

1974 • 219 citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates

1968 • 215 citations

Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

1967 • 202 citations

Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

1979 • 200 citations

Fatty acids. Part II. The nature of the oxygenated acid present in Vernonia anthelmintica(Willd.) seed oil

1954 • 177 citations

Liver microsomal expoxide hydrase. Solubilization, purification, and characterization.

1975 • 170 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene arene oxides, phenols, quinones, and dihydrodiols in bacterial and mammalian cells.

1976 • 161 citations

Insect juvenile hormones: Chemistry and action

1973 • 157 citations

Conversion of naphthalene to trans-naphthalene dihydrodiol: Evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes

1972 • 151 citations

An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats.

1981 • 150 citations

Distribution and properties of a mammalian soluble epoxide hydrase

1980 • 147 citations

Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.

1977 • 147 citations

Cytosolic and Microsomal Epoxide Hydrolases: Differential Properties in Mammalian Liver

1980 • 146 citations

The apparent ubiquity of epoxide hydratase in rat organs

1977 • 145 citations

Epoxides as products of lipid autoxidation in rat lungs

1979 • 140 citations

Benzo[ a ]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates

1977 • 134 citations

The metabolism of benz[a]anthracene and dibenz[a,h]anthracene and their 5,6-epoxy-5,6-dihydro derivatives by rat-liver homogenates

1965 • 129 citations

Purification of rat liver epoxide hydratase to apparent homogeneity

1975 • 126 citations

Isolation and identification of cholesterol α‐oxide and other minor sterols in human serum

1971 • 121 citations

A rapid assay for epoxide hydratase activity with benzo(a)pyrene 4,5-(K-region-)oxide as substrate

1976 • 120 citations

A new reaction of unsaturated fatty acid hydroperoxides: Formation of 11‐hydroxy‐12,13‐epoxy‐9‐octadecenoic acid from 13‐hydroperoxy‐9,11‐octadecadienoic acid

1973 • 117 citations

Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells: an in vitro study.

1978 • 116 citations

Interactions of the k-region epoxides of phenanthrene and dibenz[a,h]anthracene with nucleic acids and histone

1970 • 115 citations

Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase

1973 • 115 citations

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

1974 • 113 citations

Metabolism of epoxidized phosphatidylcholine by phospholipase A₂ and epoxide hydrolase

1981 • 111 citations

Rat liver cytoplasmic dihydrodiol dehydrogenase. Purification to apparent homogeneity and properties.

1980 • 107 citations

Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.

1979 • 105 citations

Solubilization, purification, and properties of a hepatic epoxide hydrase

1971 • 105 citations

The Oxidation of Cholesterol in Rat Liver Sub‐Cellular Particles

1971 • 104 citations

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

1977 • 101 citations

Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: Evidence for homologous enzymes

1971 • 100 citations

Liver microsomal epoxide hydrase.

1977 • 99 citations

The hepatic microsomal biotransformation of delta 5-steroids to 5 alpha, 6 beta-glycols via alpha- and beta-epoxides.

1981 • 98 citations

Formation of a Carcinogen in Human Skin irradiated with Ultraviolet Light

1971 • 96 citations

Continuous fluorometric assay of epoxide hydrase activity

1979 • 96 citations

Mutagenicity and cytotoxicity of benz[ a ]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides

1977 • 93 citations

Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid

1972 • 89 citations

Formation oftrans‐12,13‐epoxy‐9‐hydroperoxy‐trans‐10‐octadecenoic acid from 13‐L‐hydroperoxy‐cis‐9,trans‐11‐octadecadienoic acid catalyzed by either a soybean extract or cysteine‐FeC1₃

1978 • 89 citations

Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization

1977 • 89 citations

Distribution of enzymes involved in metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes.

1980 • 84 citations

Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.

1978 • 83 citations

Epoxides Derived from Various Polycyclic Hydrocarbons as Substrates of Homogeneous and Microsome‐Bound Epoxide Hydratase

1976 • 82 citations

Hepatic microsomal epoxide hydrase. Involvement of a histidine at the active site suggests a nucleophilic mechanism.

1978 • 80 citations

Hydration of cis- and trans-epoxymethyl stearates by the cytosolic epoxide hydrase of mouse liver

1979 • 80 citations

Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons.

1977 • 79 citations

Mammalian Metabolism and Environmental Degradation of the Juvenoid 1-(4'-Ethylphenoxy)-3,7-dimethyl-6,7-epoxy-

1974 • 76 citations

Tumor inhibitors. XXIX. Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from croton macrostachys

1968 • 74 citations

Arene Oxides-Oxepins

1973 • 74 citations

Enzymic hydration of [18O]epoxides. Role of nucleophilic mechanisms

1976 • 73 citations

Metabolism of Drugs and Toxic Substances

1964 • 73 citations

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.

1976 • 70 citations

Effects of iron overload on lipid peroxide formation and oxidative demethylation by the liver endoplasmic reticulum

1972 • 69 citations

Phylogenetic distribution of epoxide hydratase in different vertebrate species, strains and tissues measured using three substrates

1978 • 69 citations

Trans-stilbene oxide: a selective inducer of rat liver epoxide hydratase.

1978 • 69 citations

Cytosolic and microsomal epoxide hydrolases are immunologically distinguishable from each other in the rat and mouse.

1981 • 68 citations

Biosynthesis of hydroxyfatty acid polymers

1975 • 67 citations

High mutagenicity of metabolically activated chrysene 1,2 dihydrodiol: Evidence for bay region activation of chrysene

1977 • 66 citations

Characterization of rat lung epoxide (styrene oxide) hydrase with a modified radioactive assay of improved sensitivity.

1977 • 65 citations

Mechanism of the aromatization of arene oxides

1972 • 64 citations

Autoxidation of fatty acid monolayers adsorbed on silica gel: II. Rates and products

1977 • 64 citations

Metabolism of juvenile hormone I by microsomal oxidase, esterase, and epoxide hydrase of Musca domestica and some comparisons with Phormia regina and Sarcophaga bullata

1978 • 64 citations

Photometric assay of hepatic epoxide hydrolase activity with safrole oxide (SAFO) as substrate

1974 • 63 citations

A specific gas chromatographic method for the determination of microsomal styrene monooxygenase and styrene epoxide hydratase activities

1976 • 62 citations

Stereochemical course in reactions between nucleophiles and arene oxides

1974 • 62 citations

Trans-stilbene oxide: A new type of iducer of drug-metabolizing enzymes

1979 • 61 citations

Specificity of mouse liver cytosolic epoxide hydrolase for K-region epoxides derived from polycyclic aromatic hydrocarbons

1980 • 60 citations

Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene 4,5-oxide

1976 • 57 citations

Epoxide hydrolase activity in the mitochondrial and submitochondrial fractions of mouse liver

1981 • 56 citations

Effect of enzyme inducers on substrate specificity of the cytochrome P-450's.

1973 • 56 citations

A simple method for purification of epoxide hydratase from rat liver

1977 • 55 citations

Biosynthesis of the C18 family of cutin acids. ι-Hydroxyoleic acid, ι-hydroxy-9,10-epoxystearic acid, 9,10,18-trihydroxystearic acid, and their Δ¹²-unsaturated analogs

1973 • 55 citations

Insect Epoxide Hydrase Inhibition by Juvenile Hormone Analogues and Metabolic Inhibitors

1973 • 55 citations

Epoxide hydrase in human liver biopsy specimens: Assay and properties

1974 • 55 citations

Hepatic and extrahepatic formation and hydration of styrene oxide in vitro in animals of different species and sex

1978 • 54 citations

trans-Stilbene oxide: An inducer of rat hepatic microsomal and nuclear epoxide hydrase and mixed-function oxidase activities

1978 • 53 citations

Biosynthesis of hydroxy fatty acid polymers. Enzymic synthesis of cutin from monomer acids by cell-free preparations from the epidermis of Vicia faba leaves

1974 • 53 citations

The formation and hydrolysis of 16α, 17α-epoxy-oestratriene-3-ol by rat-liver tissue

1961 • 53 citations

Inactivation of a Diol Epoxide by Dihydrodiol Dehydrogenase But Not by Two Epoxide Hydrolases

1982 • 52 citations

Microsomal mixed-function oxidases and epoxide hydratase convert benzo[a]pyrene stereospecifically to optically active dihydroxydihydrobenzo[a]pyrenes

1976 • 52 citations

A rapid radiometric assay for mammalian cytosolic epoxide hydrolase

1980 • 51 citations

Initial characterization of drug-metabolizing systems in the liver of the Northern pike, Esox lucius.

1980 • 51 citations

Hepatic cytochrome P-448 and epoxide hydrase: Enzymes of nuclear origin are immunochemically identical with those of microsomal origin

1979 • 50 citations

Liver microsomal epoxide hydrase: activation, inhibition, and immunological properties of the purified enzyme.

1978 • 49 citations

Effect of phenobarbital and 3-methylcholanthrene administration on epoxide hydrase levels in liver microsomes

1977 • 48 citations

A partition assay for epoxide hydrases acting on insect juvenile hormone and an epoxide-containing juvenoid

1979 • 47 citations

Rat and human microsomal epoxide hydratase. Immunological characterization of various forms of the enzyme.

1979 • 47 citations

Gas Chromatographic Assay of Epoxide Hydrase Activity with 3-Methylcholanthrene-11,12-Oxide

1973 • 47 citations

Mechanism of catalysis for the hydration of substituted styrene oxides by hepatic epoxide hydrase

1978 • 46 citations

Properties and amino acid composition of pure epoxide hydratase

1975 • 45 citations

Fate of naturally occurring epoxy acids: A soluble epoxide hydrase, which catalyzes cis hydration, from Fusarium solani pisi

1975 • 45 citations

Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes

1976 • 45 citations

A convenient reverse-phase liquid chromatographic assay for epoxide hydrase

1980 • 43 citations

An immunohistochemical study on the localization and distribution of NADPH-cytochrome c (P-450) reductase in rat liver.

1980 • 42 citations

Assay and partial purification of epoxide hydrase from rat liver microsomes

1974 • 40 citations

Studies on enzymatic hydrolysis of aziridines—I. The conversion of 2β,3β-imino-5α-cholestane into 2β-amino-3α-hydroxy-5α-cholestane by liver microsomes

1971 • 39 citations

Benzo(a)pyrene-4,5-oxide hydratase: Assay, properties, and induction

1975 • 38 citations

Differentiation between the concerted and stepwise mechanisms for aromatization (NIH-shift) of arene epoxides

1972 • 38 citations

Epoxide hydrolase activity in the mitochondrial fraction of mouse liver

1981 • 38 citations

Stereoselective hydrolysis of cis- and trans-stilbene oxides by hepatic microsomal epoxide hydrolase

1971 • 37 citations

Hepatic microsomal epoxide hydrase. Chemical evidence for a single polypeptide chain.

1979 • 37 citations

Purification and quantitation of preneoplastic antigen from hyperplastic nodules and normal liver.

1978 • 37 citations

New potent modifiers of liver microsomal drug metabolism: 1-arylimidazoles.

1973 • 37 citations

Oxygenated fatty acids of oil from sunflower seeds after prolonged storage

1968 • 36 citations

The epoxide hydrolase catalyzed hydrolysis of trans-3-bromo-1,2-epoxycyclohexane. A direct proof for a general base catalyzed mechanism of the enzymatic hydration

1981 • 35 citations

Cholesterol α- and β-epoxides as obligatory intermediates in the hepatic microsomal metabolism of cholesterol to cholestanetriol

1980 • 35 citations

A rapid and sensitive liquid chromatographic assay for epoxide hydrase

1975 • 34 citations

Stereoselectivity in the epoxide hydrolase catalyzed hydrolysis of the stereoisomeric 3-tert-butyl-1,2-epoxycyclohexanes. Further evidence for the topology of the enzyme active site

1982 • 34 citations

Lipid epoxide hydrolase in rat lung preparations

1980 • 34 citations

Steroid epoxides in biologic systems: A review

1978 • 34 citations

Characterization of the induction of drug-metabolizing enzymes by 2-acetylaminofluorene

1981 • 33 citations

Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule.

1980 • 33 citations

Endogenous Role of Epoxide Hydratase. Development of a Steroid Epoxide-Hydratase Assay and Properties of the Enzyme

1979 • 32 citations

Microsomal epoxidation of cis-stilbene: Decrease in epoxidase activity related to lipid peroxidation

1974 • 31 citations

Immunochemical localization of epoxide hydratase in rat liver: Effects of 2-acetylaminofluorene

1979 • 31 citations

Latency of epoxide hydratase and its relationship to that of udpglucuronyltransferase

1976 • 29 citations

Determination of oxide synthetase and hydratase activities by a new highly sensitive gas chromatographic method using styrene and styrene oxide as substrates

1978 • 28 citations

Naturally occurring epoxy oils¹

1968 • 28 citations

Simplified liquid chromatographic assay for epoxide hydrolase

1980 • 28 citations

Induction of durg-metabolizing systems and related enzymes with metabolites and structural analogues of stilbene

1981 • 27 citations

Etiologic Related Studies of Ultraviolet Light-Mediated Carcinogenesis

1976 • 27 citations

Interaction of epoxide hydrolase with itself and other microsomal proteins

1982 • 27 citations

Alcohol dehydrogenase-coupled spectrophotometric assay of epoxide hydratase activity

1980 • 27 citations

Enzymatic hydration of cis-9, 10-epoxyoctadecanoic acid by cell-free extracts of germinating flax rust uredospores

1963 • 27 citations

Effect of inducers of drug-metabolizing enzymes on glutathione reductase and glutathione peroxidase in rat liver

1981 • 26 citations

Metabolic fate of epoxycholesterol in the rat

1970 • 26 citations

An immunohistochemical study on the localization and distribution of epoxide hydrolase within livers of untreated rats.

1981 • 25 citations

Epoxide hydrase: structure-activity relationships of in vitro stimulators of the microsomal activity

1978 • 24 citations

Direct evidence for the involvement of epoxide intermediates in the biosynthesis of the C18 family of cutin acids

1974 • 24 citations

Epoxide hydrase activity and its relationship to development in the southern armyworm, Prodenia eridania

1976 • 22 citations

Oxidative cleavage of the ethylenic linkage of stilbene by rabbit liver microsomes

1975 • 21 citations

A quantitative, batch hydroxyapatite method for analyzing native and denatured DNA at room temperature

1975 • 21 citations

Synthesis of epoxides with electronegative substituents. Photometric substrates for epoxide hydrase

1978 • 21 citations

Comparison of nuclear and microsomal epoxide hydrase from rat liver

1979 • 21 citations

Improved gas chromatographic method for measuring phenylethylene glycol

1980 • 21 citations

The formation of 16,17-dihydroxylated C19 steroids from 10-dehydro C19 steroids in liver microsomes from male and female rats

1973 • 21 citations

Stereoselective hydrolysis of 2,3-epoxysteroids by hepatic microsomal epoxide hydrolase

1971 • 21 citations

Epoxide hydrase activity in liver nuclei: Hydration of benzo[a]pyrene-4,5-oxide and styrene oxide

1978 • 20 citations

Hepatic microsomal biotransformation of 1,3,5(10),16-estratetraen-3-o1 to 16,17-epiestriol and estriol via 16 alpha,17 alpha- and 16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ols.

1979 • 20 citations

Studies on enzymatic hydrolysis of aziridines — II. Stereoselective hydrolysis of N-substituted 2β,3β-imino-5α-cholestanes by hepatic microsomal aziridine hydrolase

1972 • 20 citations

Stimulation of mammalian epoxide hydrase activity by flavones

1980 • 19 citations

Identification of 18‐oxo‐9,10‐epoxystearic acid, a novel compound in the cutin of young apple fruits

1973 • 19 citations

Formation of a 16,17‐trans‐glycolic metabolite from a 16‐dehydro‐androgen in human fetal liver microsomes

1973 • 19 citations

Solubilization of Epoxide Hydrolase from Liver Microsomes

1970 • 19 citations

The topology of epoxide hydratase and benzpyrene monooxygenase in the endoplasmic reticulum of rat liver

1978 • 19 citations

Juvenile hormone epoxide hydrase in house flies, flesh flies and blow flies

1978 • 19 citations

Differential inducibility of nuclear envelope epoxide hydratase by trans-stilbene oxide and phenobarbital.

1982 • 19 citations

Enzymic hydration of benzene oxide: Assay and properties

1980 • 18 citations

Hepatic microsomal conversion of pregnenolone to 3β,5,6β-trihydroxy-5α-pregnan-20-one via pregnenolone α- and β-epoxides

1980 • 18 citations

New heterocyclic stimulators of hepatic epoxide hydrolase

1981 • 17 citations

A sensitive fluorometric assay for epoxide hydratase

1982 • 17 citations

Immunohistochemical localization of epoxide hydratase in rat liver

1980 • 16 citations

[Biogenesis of estratetraenol in man].

1963 • 15 citations

Benzil, a Potent Activator of Microsomal Epoxide Hydrolase in vitro

1980 • 15 citations

Chemical reactivity and metabolism of norethindrone-4β,5β-epoxide by rat liver microsomes in vitro

1980 • 14 citations

Human hepatic microsomal epoxide hydrolase. A structural comparison with the rat enzyme.

1982 • 14 citations

Accumulation of an epoxy intermediate during the hepatic microsomal metabolism of cis-stilbene to threo-stilbene glycol due to the inhibition of epoxide hydrolase by trans-stilbenimine

1974 • 13 citations

Reconstitution of benzo[a] pyrene 4,5‐oxide reductase activity by purified cytochrome P‐450

1978 • 12 citations

Stoffwechsel von Δ^1.3.5(10).16-Östratetraenol-(3), 16α. 17α- und 16β.17ß-Epoxy-Δ^1.3.5(10)-östratrienol-(3) beim Menschen

1962 • 12 citations

Ligand binding to dopamine-receptors: Analysis & interpretation

1978 • 12 citations

BIOGENESE VON ÖSTRATETRAENOL BEIM MENSCHEN

1963 • 11 citations

A practical radiochromatographic assay for cholesterol epoxide hydrase

1979 • 10 citations

Gas chromatographic and mass fragmentographic assays of carcinogenic polycyclic hydrocarbon epoxide hydratase activity

1977 • 10 citations

Immuno-electron-microscopic studies on the subcellular distribution of rat liver epoxide hydrolase and the effect of phenobarbitone and 2-acetamidofluorene treatment

1982 • 10 citations

Monooxygenase and epoxide hydratase analysis by high-performance liquid chromatography

1978 • 10 citations

Norethisterone-4β,5-oxide and laevonorgestrel-4β,5-oxide: Formation in rat liver microsomal incubations and interference with microsomal epoxide hydrolase and cytoplasmic glutathione S-transferase

1981 • 9 citations

trans-Stilbene oxide: A new inducer of rat liver microsomal UDP-glucuronyltransferase

1979 • 9 citations

Induction of hepatic cytosolic DT diaphorase in rats treated with trans—stilbene oxide

1980 • 9 citations

Bleaching of vegetable oils. II. Conversions of methyl oleate and linoleate

1973 • 7 citations

Inhibition of rat hepatic microsomal styrene oxide hydration by mercury and zincin vitro

1980 • 7 citations

A highly sensitive assay for epoxide hydrolase using an endogenous epoxide as substrate: 16α, 17α-epoxyandrost-4-en-3-one

1981 • 6 citations

Topology of Epoxide Hydrolase in the Membrane of the Endoplasmic Reticulum.

1982 • 6 citations

The effect of trans-stilbene oxide and other structurally related inducers of drug-metabolizing enzymes on the pentose phosphate pathway and other enzymes of carbohydrate metabolism

1982 • 6 citations

The effect of trans-stilbene oxide and other structurally related inducers of drug-metabolizing enzymes on glucuronidation

1982 • 5 citations

Hepatic microsomal epoxide hydratase of bluegill

1979 • 5 citations

The Formation of Phenylethane-1,2-diol 2-Acetate in the Metabolism of Styrene Oxide by Rabbit Liver Microsomesin vitro

1979 • 4 citations

A Very Sensitive Gas Chromatographic Method for the Evaluation of Styrene Oxidase and Styrene Oxide Hydratase Activities

1978 • 4 citations

Improved syntheses of substrates for radiometric assays of microsomal monooxygenase (arylhydrocarbon hydroxylase) and epoxide hydratase

1977 • 3 citations

Kinetics of the inhibition of styrene oxide and hydration in rat liver microsomes by cadmium

1980 • 3 citations