Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Hepatocarcinogenesis: a dynamic cellular perspective.

1987 • 414 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.

1980 • 243 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.

1984 • 222 citations

Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA

1985 • 215 citations

Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver.

1983 • 194 citations

The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.

1976 • 188 citations

A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat.

1985 • 185 citations

Virus-specific transcription in bovine papillomavirus-transformed mouse cells

1982 • 162 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

Human placental form of glutathione S-transferase (GST-pi) as a new immunohistochemical marker for human colonic carcinoma.

1986 • 133 citations

A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.

1976 • 118 citations

The biochemistry of preneoplastic liver: a common metabolic pattern in hepatocyte nodules

1984 • 101 citations

Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.

1983 • 86 citations

Characterization of drug-metabolizing systems in hyperplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet

1983 • 79 citations

Development of resistance to cytotoxicity during aflatoxin carcinogenesis

1977 • 68 citations

Overexpression and Amplification of Five Genes in a Multidrug-Resistant Chinese Hamster Ovary Cell Line

1986 • 68 citations

Increased uridine diphosphate-glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas.

1982 • 65 citations

Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver

1979 • 54 citations

The pattern of metabolism of 2-acetylaminofluorene in carcinogen-induced hepatocyte nodules in comparison to normal liver

1986 • 27 citations

5' Nucleotide sequences influence serum-modulated expression of a human dihydrofolate reductase minigene.

1986 • 15 citations