Ultrasensitivity in the mitogen-activated protein kinase cascade.

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

An amplified sensitivity arising from covalent modification in biological systems.

1981 • 1,211 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Amplification and Adaptation in Regulatory and Sensory Systems

1982 • 464 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

1993 • 264 citations

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

1992 • 264 citations

Interconvertible Enzyme Cascades in Cellular Regulation

1980 • 257 citations

Meiotic initiation by the mos protein in Xenopus

1992 • 253 citations

Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects.

1984 • 235 citations

Superiority of interconvertible enzyme cascades in metabolic regulation: Analysis of multicyclic systems

1977 • 173 citations

Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.

1993 • 168 citations

Sensitivity amplification in biochemical systems

1982 • 165 citations

Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

1996 • 164 citations

Constitutive activation of Mek1 by mutation of serine phosphorylation sites.

1994 • 145 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

1994 • 128 citations

1 MAP Kinases in Mitogenesis and Development

1996 • 109 citations

Mos Stimulates MAP Kinase in Xenopus Oocytes and Activates a MAP Kinase Kinase In Vitro

1993 • 82 citations

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

1993 • 76 citations

Determination of v-Mos-Catalyzed Phosphorylation Sites and Autophosphorylation Sites on MAP Kinase Kinase by ESI/MS

1995 • 75 citations

Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system.

1996 • 62 citations