Ras - a versatile cellular switch

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

1997 • 1,592 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

The ins and outs of Raf kinases

1994 • 537 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

14-3-3 and its possible role in co-ordinating multiple signalling pathways

1996 • 367 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction

1995 • 312 citations

Cell determination strategies in the Drosophila eye

1997 • 308 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

1998 • 295 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye

1991 • 255 citations

KSR modulates signal propagation within the MAPK cascade.

1996 • 252 citations

14-3-3 proteins associate with cdc25 phosphatases.

1995 • 251 citations

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1997 • 229 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

Bcr and Raf form a complex in vivo via 14-3-3 proteins.

1995 • 201 citations

The effector interactions of p21ras

1993 • 193 citations

Requirement of the Drosophila raf homologue for torso function

1989 • 181 citations

The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling

1998 • 168 citations

How ras-related proteins talk to their effectors

1996 • 162 citations

Control of B cell development by Ras-mediated activation of Raf

1997 • 152 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

The heat shock protein 83(Hsp83) is required for Raf-mediated signalling in Drosophila

1997 • 140 citations

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

1996 • 134 citations

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila.

1997 • 130 citations

14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain

1997 • 127 citations

An Intact Raf Zinc Finger Is Required for Optimal Binding to Processed Ras and for Ras-Dependent Raf Activation In Situ

1997 • 120 citations

Ras-dependent activation of the small GTPase Ral

1998 • 112 citations

The torso receptor tyrosine kinase can activate raf in a ras-independent pathway

1995 • 111 citations

Genetics of signal transduction in invertebrates

1994 • 96 citations

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.

1997 • 95 citations

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

1998 • 93 citations

Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling

1997 • 89 citations

Kinase Suppressor of Ras Inhibits the Activation of Extracellular Ligand-regulated (ERK) Mitogen-activated Protein (MAP) Kinase by Growth Factors, Activated Ras, and Ras Effectors

1998 • 86 citations

Transcription factors in eye development: a gorgeous mosaic?

1997 • 75 citations

Control and integration of cell signaling pathways during C. Elegans vulval development

1996 • 70 citations

Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos

1997 • 56 citations

KSR: A novel player in the RAS pathway

1995 • 51 citations

Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo

1997 • 50 citations

Nuclear factors in sevenless signalling

1995 • 50 citations

Recent advances in understanding signal transduction pathways in worms and flies

1996 • 37 citations

The Activity of D-raf in Torso Signal Transduction Is Altered by Serine Substitution, N-Terminal Deletion, and Membrane Targeting

1996 • 22 citations