The MKK7 Gene Encodes a Group of c-Jun NH₂-Terminal Kinase Kinases

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK

1997 • 569 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

High-resolution mapping of mammalian genes by in situ hybridization to free chromatin.

1992 • 514 citations

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

1996 • 443 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

Modes of DAPI banding and simultaneous in situ hybridization

1993 • 397 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

1998 • 336 citations

hemipterous encodes a novel drosophila MAP kinase kinase, required for epithelial cell sheet movement

1995 • 331 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

1996 • 326 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?

1997 • 318 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2is regulated by phosphorylation

1998 • 270 citations

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

1998 • 266 citations

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH ₂ -terminal kinase activation, and defects in AP-1 transcriptional activity

1997 • 266 citations

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

1997 • 258 citations

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1997 • 257 citations

Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

1997 • 242 citations

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.

1996 • 230 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.

1996 • 227 citations

Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms

1995 • 221 citations

The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1

1996 • 221 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

1998 • 196 citations

Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor β (TGF-β)-activated Kinase (TAK1), a Kinase Mediator of TGF β Signal Transduction

1997 • 193 citations

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

1997 • 193 citations

Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

1996 • 193 citations

A Conserved p38 Mitogen-Activated Protein Kinase Pathway Regulates Drosophila Immunity Gene Expression

1998 • 192 citations

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

1997 • 189 citations

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

1997 • 183 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade

1997 • 181 citations

MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase

1997 • 173 citations

A Novel Mechanism of JNK1 Activation

1997 • 171 citations

Purification and Identification of a Major Activator for p38 from Osmotically Shocked Cells

1996 • 166 citations

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

1997 • 154 citations

Molecular Cloning and Characterization of a Novel Protein Kinase with a Catalytic Domain Homologous to Mitogen-activated Protein Kinase Kinase Kinase

1996 • 149 citations

Dual Leucine Zipper-bearing Kinase (DLK) Activates p46SAPK and p38 but Not ERK2

1996 • 140 citations

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.

1996 • 130 citations

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

1997 • 128 citations

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1996 • 127 citations

Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells

1996 • 123 citations

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

1997 • 120 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine‐zipper domains

1993 • 111 citations

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

1997 • 111 citations

Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

1997 • 110 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Direct Activation of the Stress-activated Protein Kinase (SAPK) and Extracellular Signal-regulated Protein Kinase (ERK) Pathways by an Inducible Mitogen-activated Protein Kinase/ERK Kinase Kinase 3 (MEKK) Derivative

1997 • 101 citations

Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli

1998 • 100 citations

Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

1997 • 100 citations

Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain

1997 • 82 citations

SH2/SH3 Adaptor Proteins Can Link Tyrosine Kinases to a Ste20-related Protein Kinase, HPK1

1997 • 76 citations

A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase

1997 • 75 citations

Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis.

1993 • 67 citations

SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development

1998 • 67 citations

The Stress‐activated Protein Kinases

1995 • 56 citations

SKK4, a novel activator of stress‐activated protein kinase‐1 (SAPK1/JNK)

1997 • 52 citations

Differential Activation of Two JNK Activators, MKK7 and SEK1, by MKN28-derived Nonreceptor Serine/Threonine Kinase/Mixed Lineage Kinase 2

1998 • 47 citations

Ras‐Dependent and Ras‐Independent Activation Pathways for the Stress‐Activated‐Protein‐Kinase Cascade

1996 • 43 citations

The Gene Encoding Protein Kinase SEK1 Maps to Mouse Chromosome 11 and Human Chromosome 17

1996 • 8 citations