Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

The "megaprimer" method of site-directed mutagenesis.

1990 • 1,174 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

New mammalian expression vectors

1990 • 525 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system.

1989 • 401 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1995 • 214 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

A template for the protein kinase family

1993 • 196 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase.

1994 • 154 citations

Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1979 • 145 citations

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

1995 • 144 citations

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

1991 • 143 citations

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.

1992 • 133 citations

Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit.

1992 • 122 citations

The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.

1991 • 112 citations

Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

1994 • 104 citations

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C

1993 • 88 citations

Cell cycle regulation of vertebrate p34cdc2 activity: identification of Thr161 as an essential in vivo phosphorylation site.

1992 • 50 citations

[49] Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase

1991 • 46 citations

Crystallization and Preliminary X-ray Studies of Extracellular Signal-regulated Kinase-2/MAP Kinase with an Incorporated His-tag

1993 • 34 citations