Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

Regulators of Angiogenesis

1991 • 959 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.

1990 • 390 citations

The regulated expression of erythropoietin by two human hepatoma cell lines.

1987 • 374 citations

Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression.

1992 • 216 citations

FNR‐dependent repression of the ndh gene of Escherichia coli and metal ion requirement for FNR‐regulated gene expression

1989 • 146 citations

2 The development of iron chelating drugs

1989 • 129 citations

Gene Expression in Low Oxygen Tension

1993 • 79 citations

Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines

1994 • 46 citations