Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

1995 • 990 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

1992 • 900 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR

1998 • 662 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

1996 • 562 citations

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

1998 • 496 citations

Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells

1995 • 487 citations

Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.

1994 • 433 citations

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

1994 • 430 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.

1992 • 355 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

1996 • 342 citations

Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats

1997 • 311 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

VEGF and flt

1996 • 276 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Functional Upregulation of the Vascular Endothelial Growth Factor Receptor KDR by Hypoxia

1996 • 261 citations

Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells

1996 • 239 citations

Regulation of Vascular Endothelial Growth Factor in Cardiac Myocytes

1995 • 212 citations

Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo

1998 • 207 citations

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.

1997 • 196 citations

Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system.

1997 • 195 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis

1997 • 171 citations

Vascular endothelial growth factor and its receptors in normal human testicular tissue

1997 • 143 citations

Angiogenesis in Embryos and Ischemic Diseases

1997 • 139 citations

Differential Expression of Vascular Endothelial Growth Factor (Vascular Permeabilty Factor) Forms in Rat Tissues

1995 • 137 citations

Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures

1995 • 125 citations

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]

1995 • 118 citations

Hypoxia‐induced brain angiogenesis in the adult rat.

1995 • 104 citations

Nuclear Factor Interleukin 6 Motifs Mediate Tissue-specific Gene Transcription in Hypoxia

1997 • 78 citations

Hypoxic induction of gene expression in chronic granulomatous disease- derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase

1996 • 77 citations

Hypoxia and cobalt stimulate vascular endothelial growth factor receptor gene expression in rats

1997 • 40 citations

Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo

1996 • 39 citations

Brain Metabolic and Vascular Adaptations to Hypoxia in the Rat

1997 • 19 citations

Imaging Hypoxia and Blood Flow in Normal Tissues

1997 • 18 citations

Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo

1996 • 9 citations