Constitutive Expression of phVEGF ₁₆₅ After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Angiogenesis.

1992 • 2,581 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Gene therapy - promises, problems and prospects

1997 • 1,692 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.

1994 • 616 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

The Epidemiology of Lower Extremity Amputations in Diabetic Individuals

1983 • 573 citations

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

1996 • 555 citations

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

1989 • 497 citations

Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells

1995 • 487 citations

Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice

1993 • 440 citations

Direct Intramuscular Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor Augments Collateral Development and Tissue Perfusion

1996 • 396 citations

Direct Gene Transfer into Skeletal MuscleIn Vivo: Factors Affecting Efficiency of Transfer and Stability of Expression

1993 • 380 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

An Improved Plasmid DNA Expression Vector for Direct Injection into Skeletal Muscle

1996 • 336 citations

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

1995 • 330 citations

Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: Dose-response effect of basic fibroblast growth factor

1992 • 325 citations

Magnetic Resonance Imaging of Angiographically Occult Runoff Vessels in Peripheral Arterial Occlusive Disease

1992 • 316 citations

Mechanisms of Angiogenesis

1987 • 304 citations

Clinical Trials for Claudication

1995 • 288 citations

VEGF Improves Myocardial Blood Flow but Produces EDRF-Mediated Hypotension in Porcine Hearts

1996 • 270 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Produces Nitric Oxide–Dependent Hypotension

1997 • 268 citations

Vascular Endothelial Growth Factor Inhibits Endothelial Cell Apoptosis Induced by Tumor Necrosis Factor-α: Balance Between Growth and Death Signals

1997 • 221 citations

Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.

1996 • 215 citations

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.

1997 • 203 citations

Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood.

1996 • 199 citations

Gene Transfer in Regenerating Muscle

1994 • 181 citations

Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector.

1996 • 181 citations

DNA Synthesis and Mitoses in Coronary Collateral Vessels of the Dog

1971 • 178 citations

Therapeutic Angiogenesis Following Arterial Gene Transfer of Vascular Endothelial Growth Factor in a Rabbit Model of Hindlimb Ischemia

1996 • 170 citations

Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.

1993 • 167 citations

Assessment of quality of life of patients with severe ischemia as a result of infrainguinal arterial occlusive disease

1992 • 135 citations

Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.

1993 • 134 citations

Standards for evaluating and reporting the results of surgical and percutaneous therapy for peripheral arterial disease.

1991 • 121 citations

Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression.

1994 • 93 citations

Use of Synchrotron Radiation Microangiography to Assess Development of Small Collateral Arteries in a Rat Model of Hindlimb Ischemia

1997 • 82 citations

Guidelines for Percutaneous Transluminal Angioplasty

1990 • 81 citations

Increased expression of direct gene transfer into skeletal muscles observed after acute ischemic injury in rats.

1996 • 79 citations

Lower limb amputation: striking the balance.

1994 • 58 citations

Amputation for occusive arterial disease

1992 • 54 citations

Late outcomes of limb loss after failed infrainguinal bypass

1995 • 50 citations

Amputation for premature peripheral atherosclerosis: do young patients do better?

1996 • 13 citations