Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

Real time quantitative PCR.

1996 • 6,155 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

1997 • 512 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1997 • 305 citations

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.

1996 • 251 citations

Endothelial Cell Death Induced by Tumor Necrosis Factor-α Is Inhibited by the Bcl-2 Family Member, A1

1996 • 247 citations

2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Induces Apoptosis in Endothelial Cells and Inhibits Angiogenesis: Possible Role for Stress-Activated Protein Kinase Signaling Pathway and Fas Expression

1997 • 193 citations

Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax

1996 • 185 citations

Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells

1996 • 172 citations

Interaction of the Flt-1 Tyrosine Kinase Receptor with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 123 citations

Transforming Growth Factor β1 Induces Apoptotic Cell Death in Cultured Human Umbilical Vein Endothelial Cells with Down-Regulated Expression of BCL-2

1995 • 106 citations

bcl-2 Gene Prevents Apoptosis of Basic Fibroblast Growth Factor-Deprived Murine Aortic Endothelial Cells

1994 • 63 citations

Immunihistochemical detection of Bcl-2 in AIDS-associated and classical Kaposi's sarcoma.

1996 • 59 citations

Cell cycle: Immunolocalization of bcl-2 in the human corpus luteum

1995 • 54 citations

Receptor tyrosine kinase signaling in vascular development.

1997 • 36 citations

Use of Green Fluorescent Protein in Studies of Apoptosis of Transfected Cells

1997 • 19 citations