Insulin-Like Growth Factors

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Insulin-Like Growth Factors as Intraovarian Regulators of Granulosa Cell Growth and Function*

1985 • 921 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Insulin-like growth factor I stimulates growth in hypophysectomized rats

1982 • 605 citations

Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*

1987 • 580 citations

Regulation of insulin-like growth factor I gene expression by growth hormone.

1986 • 558 citations

Short-Term Metabolic Effects of Recombinant Human Insulin-like Growth Factor I in Healthy Adults

1987 • 554 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.

1986 • 524 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

Insulin Regulates the Serum Levels of Low Molecular Weight Insulin-Like Growth Factor-Binding Protein*

1988 • 489 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts

1988 • 488 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*

1983 • 447 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats.

1988 • 424 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

1986 • 371 citations

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*

1981 • 369 citations

Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein

1988 • 367 citations

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

1988 • 363 citations

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

1983 • 354 citations

Estrogen Induces Insulin—Like Growth Factor—I Expression in the Rat Uterus

1987 • 353 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Insulin-Like Growth Factor (IGF) Binding Protein from Human Decidua Inhibits the Binding and Biological Action of IGF-I in Cultured Choriocarcinoma Cells**

1988 • 347 citations

Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia

1988 • 346 citations

Insulin-like growth factor-binding protein from human plasma. Purification and characterization.

1986 • 343 citations

Sequence of a cDNA clone encoding human preproinsulin-like growth factor II

1984 • 326 citations

Hormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts

1981 • 323 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Regulation by Growth Hormone of Number of Chondrocytes Containing IGF-I in Rat Growth Plate

1986 • 314 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats.

1986 • 306 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

1987 • 292 citations

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1984 • 281 citations

Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve

1989 • 280 citations

Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene.

1987 • 279 citations

Molecular Cloning of Rat Insulin-Like Growth Factor I Complementary Deoxyribonucleic Acids: Differential Messenger Ribonucleic Acid Processing and Regulation by Growth Hormone in Extrahepatic Tissues

1987 • 275 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Cross-reaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid

1984 • 266 citations

Pulsatile Intravenous Growth Hormone (GH) Infusion to Hypophysectomized Rats Increases Insulin-Like Growth Factor I Messenger Ribonucleic Acid in Skeletal Tissues More Effectively than Continuous GH Infusion*

1988 • 264 citations

Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors

1989 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).

1988 • 254 citations

Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin*

1988 • 252 citations

Cloning, characterization, and expression of a human insulin-like growth factor binding protein

1988 • 249 citations

Soluble 34K Binding Protein Inhibits the Binding of Insulin-like Growth Factor I to Its Cell Receptors in Human Secretory Phase Endometrium: Evidence for Autocrine/Paracrine Regulation of Growth Factor Action*

1988 • 249 citations

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 • 247 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.

1988 • 244 citations

Identification, Characterization, and Regulation of a Rat Complementary Deoxyribonucleic Acid which Encodes Insulin-Like Growth Factor-I*

1987 • 241 citations

Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues.

1987 • 240 citations

Characterization of the Acid-Labile Subunit of the Growth Hormone-Dependent Insulin-Like Growth Factor Binding Protein Complex*

1988 • 239 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

Differential Effects of Estrogen and Growth Hormone on Uterine and Hepatic Insulin-Like Growth Factor I Gene Expression in the Ovariectomized Hypophysectomized Rat*

1988 • 236 citations

Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.

1988 • 233 citations

Insulin-Like Growth Factor (IGF) Binding Protein Complementary Deoxyribonucleic Acid from Human HEP G2 Hepatoma Cells: Predicted Protein Sequence Suggests an IGF Binding Domain Different from Those of the IGF-I and IGF-II Receptors

1988 • 232 citations

Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I.

1986 • 231 citations

The Somatomedins: Insulin-Like Growth Factors

1986 • 231 citations

Radioimmunoassay of a 26,000-Dalton Plasma Insulin-Like Growth Factor-Binding Protein: Control by Nutritional Variables*

1988 • 231 citations

Diurnal Rhythm of Growth Hormone-Independent Binding Protein for Insulin-like Growth Factors in Human Plasma*

1987 • 227 citations

Distribution and Regulation of Rat Insulin-Like Growth Factor I Messenger Ribonucleic Acids Encoding Alternative Carboxyterminal E-Peptides: Evidence for Differential Processing and Regulation in Liver

1988 • 224 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.

1989 • 221 citations

Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell Line

1981 • 221 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Insulin-Like Growth Factor (IGF) and IGF-Binding Proteins: Comparison of Human Serum and Lymph*

1988 • 216 citations

Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors

1986 • 215 citations

Use of plasma somatomedin-C/insulin-like growth factor I measurements to monitor the response to nutritional repletion in malnourished patients

1985 • 214 citations

Inhibition of biological activity of multiplication-stimulating activity by binding to its carrier protein.

1980 • 212 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

Placental Protein 12 Is a Decidual Protein that Binds Somatomedin and Has an Identical N-Terminal Amino Acid Sequence with Sdmatomedin-Binding Protein from Human Amhiotic Fluid*

1986 • 211 citations

Primary structure of human insulin‐like growth factor‐binding protein/placental protein 12 and tissue‐specific expression of its mRNA

1988 • 210 citations

Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor.

1988 • 210 citations

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

1985 • 205 citations

Hormonal Proteins and Peptides

1983 • 205 citations

Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-II

1988 • 204 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

1985 • 203 citations

Pattern of the insulin-like growth factor II gene expression during rat embryogenesis

1988 • 199 citations

The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.

1988 • 199 citations

Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities.

1986 • 197 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Isolation and characterization of a somatomedin‐binding protein from mid‐term human amniotic fluid

1984 • 194 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

The Somatomedin C Binding Protein: Evidence for a Heterologous Subunit Structure*

1980 • 193 citations

Histochemical localization of IGF-I and -II mRNA in the developing rat embryo

1987 • 193 citations

The Generation of Insulin-Like Growth Factor-1—Sensitive Cells by Growth Hormone Action

1986 • 192 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.

1988 • 192 citations

Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein.

1987 • 192 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor.

1988 • 190 citations

Insulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated form

1988 • 190 citations

Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

1989 • 188 citations

Growth Hormone Dependence of Somatomedin-C/lnsulin-Like Growth Factor-I and Insulin-Like Growth Factor-ll Messenger Ribonucleic Acids*

1987 • 186 citations

Regulation of Insulin-Like Growth Factor Messenger Ribonucleic Acid in Rat Growth Plate by Growth Hormone*

1988 • 183 citations

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

1984 • 180 citations

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

1988 • 179 citations

Peroxide(s) of vanadium : A novel and potent insulin-mimetic agent which activates the insulin receptor kinase

1987 • 177 citations

Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.

1986 • 174 citations

Heterogeneity of insulin‐like growth factor binding proteins and relationships between structure and affinity

1987 • 173 citations

Serum somatomedin binding proteins: physiologic significance and interference in radioligand assay.

1987 • 173 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

Inhibition of the Action of Nonsuppressible Insulin-Like Activity on Isolated Rat Fat Cells by Binding to its Carrier Protein

1979 • 170 citations

The human insulin‐like growth factor II gene contains two development‐specific promoters

1987 • 170 citations

Biosynthesis and turnover of the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1983 • 169 citations

Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane.

1984 • 169 citations

Radioimmunoassay of placental protein 12: Levels in amniotic fluid, cord blood, and serum of healthy adults, pregnant women, and patients with trophoblastic disease

1982 • 168 citations

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

1986 • 166 citations

Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor I/somatomedin C and human growth hormone.

1988 • 166 citations

Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus

1987 • 165 citations

Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors.

1987 • 165 citations

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

1985 • 164 citations

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

1987 • 161 citations

Satellite cells express the trophic factor IGF‐I in regenerating skeletal muscle

1987 • 161 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

1982 • 158 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

Somatomedin-C/Insulin-Like Growth Factor I as an Enhancer of Androgen Biosynthesis by Cultured Rat Ovarian Cells*

1988 • 154 citations

46 kd mannose 6-phosphate receptor: Cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor

1987 • 150 citations

Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

1987 • 148 citations

Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors

1983 • 147 citations

Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone

1976 • 146 citations

Differential expression of the human insulin-like growth factor II gene Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein

1988 • 146 citations

The receptor for insulin-like growth factor II mediates an insulin-like response.

1987 • 145 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

Two Immunoreactive Binding Proteins for Insulin-Like Growth Factors in Human Amniotic Fluid: Relationship to Fetal Maturity*

1987 • 142 citations

Immunoreactive Somatomedin-C/Insulin-Like Growth Factor I and Its Binding Protein in Human Milk*

1984 • 141 citations

Relative Increase in Insulin-Like Growth Factor I Messenger Ribonucleic Acid Levels in Compensatory Renal Hypertrophy*

1987 • 140 citations

NUTRITIONALLY-INDUCED CHANGES IN HEPATIC INSULIN-LIKE GROWTH FACTOR I (IGF-I) GENE EXPRESSION IN RATS.

1987 • 140 citations

Synthesis of Placental Protein 12 by Human Endometrium*

1986 • 139 citations

Synthesis of Placental Protein 12 by Human Decidua

1985 • 139 citations

PARTIAL PURIFICATION AND CHARACTERIZATION OF A BINDING PROTEIN FOR INSULIN-LIKE ACTIVITY (ILAs) IN HUMAN AMNIOTIC FLUID: A POSSIBLE INHIBITOR OF INSULIN-LIKE ACTIVITY

1979 • 139 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

Hypoglycemia Associated with Non-Islet-Cell Tumor and Insulin-like Growth Factors

1981 • 136 citations

Porcine Insulin-Like Growth Factor-I (pIGF-I): Complementary Deoxyribonucleic Acid Cloning and Uterine Expression of Messenger Ribonucleic Acid Encoding Evolutionary Conserved IGF-I Peptides*

1988 • 136 citations

The C Region of Human Insulin-like Growth Factor (IGF) I Is Required for High Affinity Binding to the Type 1 IGF Receptor

1989 • 135 citations

Relation of Kidney Tissue Somatomedin-C/Insulin-Like Growth Factor I to Postnephrectomy Renal Growth in the Rat*

1985 • 135 citations

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

1981 • 132 citations

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

1983 • 132 citations

Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation media.

1986 • 130 citations

Insulin-Like Growth Factor II Messenger Ribonucleic Acids are Synthesized in the Choroid Plexus of the Rat Brain

1988 • 127 citations

Isolation of a Somatomedin-Binding Protein from Preterm Amniotic Fluid. Development of a Radioimmunoassay*

1984 • 127 citations

Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface.

1984 • 126 citations

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.

1987 • 125 citations

The bovine insulin-like growth factor (IGF) binding protein purified from conditioned medium requires the N-terminal tripeptide in IGF-1 for binding

1988 • 123 citations

Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?

1987 • 123 citations

Plasma Somatomedin-Binding Proteins in Hypopituitarism: Changes during Growth Hormone Therapy*

1981 • 123 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

INSULIN-LIKE GROWTH FACTOR-I MODULATES ENDOTHELIAL CELL CHEMOTAXIS

1987 • 121 citations

IGF-2 stimulated growth mediated by the somatomedin type 2 receptor

1987 • 121 citations

Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.

1988 • 121 citations

The Ontogeny of Growth Hormone Receptors in the Rabbit Tibia*

1988 • 121 citations

Immunoassay of a Somatomedin-Binding Protein from Human Amniotic Fluid: Levels in Fetal, Neonatal, and Adult Sera*

1984 • 120 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.

1985 • 119 citations

Regenerating endothelial cells express insulin-like growth factor-I immunoreactivity after arterial injury

1987 • 119 citations

Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*

1987 • 118 citations

Identification of an insulin‐like growth factor‐binding protein in human cerebrospinal fluid with a selective affinity for IGF‐II

1986 • 118 citations

Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats

1987 • 115 citations

Production of Insulin-Like Growth Factor I and Its Binding Protein by Adult Rat Hepatocytes in Primary Culture*

1985 • 115 citations

Human Preovulatory Follicular Fluid, Luteinized Cells of Hyperstimulated Preovulatory Follicles, and Corpus Luteum Contain Placental Protein 12*

1984 • 114 citations

Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.

1985 • 113 citations

Effect of in Vitro Action of Serum Proteases or Exposure to Acid on Measurable Immunoreactive Somatomedin-C in Serum*

1983 • 112 citations

Tissue and Development Specific Regulation of a Complex Family of Rat Insulin-Like Growth Factor I Messenger Ribonucleic Acids

1988 • 111 citations

Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the type 2 insulin-like growth factor receptor.

1988 • 110 citations

Insulin-like growth factors stimulate chemotaxis in human melanoma cells

1988 • 108 citations

Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells.

1986 • 108 citations

The riddle of tumour hypoglycaemia revisited

1980 • 108 citations

The Type II Insulin-Like Growth Factor Receptor Does Not Mediate Deoxyribonucleic Acid Synthesis in Human Fibroblasts*

1987 • 108 citations

Amino acid sequence of a variant pro-form of insulin-like growth factor II.

1985 • 106 citations

Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor

1988 • 106 citations

Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor

1984 • 105 citations

Isolation of Rat Testis cDNAs Encoding an Insulin-Like Growth Factor I Precursor

1987 • 105 citations

Liberation of Immunoreactive Somatomedin-C from Its Binding Proteins by Proteolytic Enzymes and Heparin*

1983 • 105 citations

Type II insulin-like growth factor receptor is present in rat serum.

1987 • 104 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

Induction of mRNA for IGF-I and -II during growth hormone-stimulated muscle hypertrophy

1988 • 103 citations

Regulation of the Growth Hormone-Independent Growth Factor-Binding Protein in Children

1988 • 102 citations

Developmental Expression of the Tissue Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor in the Rat

1989 • 102 citations

3 Somatomedin/insulin-like growth factor tissue receptors

1984 • 101 citations

The Growth Hormone Dependence of a Somatomedin-Binding Protein in Human Serum*

1981 • 101 citations

Maternal and neonatal somatomedin C/insulin-like growth factor-I (IGF-I) and IGF binding proteins during early lactation in the pig

1988 • 101 citations

Characterization of a somatomedin (insulin-like growth factor) synthesized by fetal rat liver organ cultures.

1979 • 100 citations

Focal expression of insulin-like growth factor I in rat kidney collecting duct.

1988 • 100 citations

Insulin-Like Growth Factor I Stimulates Human Erythroid Colony Formationin Vitro

1987 • 99 citations

The somatomedin-binding protein isolated from a human hepatoma cell line is identical to the human amniotic fluid somatomedin-binding protein

1985 • 99 citations

Insulinlike growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers

1988 • 98 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Isolation and characterization of variant IGF‐1 as well as IGF‐2 from adult human brain

1986 • 97 citations

Insulin-Like Growth Factor Carrier Proteins in Neonatal and Adult Rat Serum Are Immunologically Different: Demonstration Using a New Radioimmunoassay for the Carrier Protein from BRL-3A Rat Liver Cells

1986 • 96 citations

Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor.

1987 • 95 citations

Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

1987 • 95 citations

EGF and insulin action in fibroblasts

1986 • 93 citations

Sequence of a Placental cDNA Encoding the Mouse Insulin-Like Growth Factor II Precursor

1986 • 93 citations

Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin, and insulin-like growth factor II.

1985 • 92 citations

Free Insulin-Like Growth Factor I (IGF-I) and IGF-II in Human Saliva*

1988 • 91 citations

Expression of insulin-like growth factor I (IGF-I) and IGF-II mRNA during hepatic development, proliferation and carcinogenesis in the rat

1988 • 91 citations

A new candidate for the regulation of erythropoiesis

1982 • 91 citations

Rat Hepatocyte Insulin-Like Growth Factor I and Binding Protein: Effect of Growth Hormonein Vitroandin Vivo*

1985 • 91 citations

Mannose 6-phosphate/insulin-like growth factor II receptor: Distinct binding sites for mannose 6-phosphate and insulin-like growth factor II

1988 • 91 citations

Natural and synthetic forms of insulin-like growth factor-1 (IGF-1) and the potent derivative, destripeptide IGF-1: Biological activities and receptor binding

1987 • 90 citations

Purification and Characterization of a Unique High Molecular Weight Form of Insulin-Like Growth Factor II

1987 • 90 citations

Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor

1987 • 89 citations

A promoter of the rat insulin-like growth factor II gene consists of minimal control elements

1988 • 88 citations

Polypeptide Hormone Receptors.

1985 • 88 citations

Organization of the human genes for insulin‐like growth factors I and II

1986 • 88 citations

Serum Levels of Somatomedins and Somatomedin-Binding Protein in Pregnant Women with Type I or Gestational Diabetes and Their Infants*

1986 • 88 citations

Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor

1988 • 87 citations

Effects of growth hormone and insulin-like growth factor-I on colony formation of rabbit epiphyseal chondrocytes at different stages of maturation

1987 • 87 citations

The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand.

1986 • 87 citations

Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosa

1988 • 86 citations

Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region

1987 • 85 citations

Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

1983 • 85 citations

Purification and biologic properties of fibroblast somatomedin.

1986 • 84 citations

Isolation and characterization of insulin-like growth factor-II from human bone

1988 • 83 citations

A Preferential Binding Site for Insulin-Like Growth Factor II in Human andRat Placental Membranes*

1981 • 82 citations

Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes.

1982 • 80 citations

The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors.

1985 • 78 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

Insulin-Like Growth Factor-Binding Proteins (IGF-BPs) Produced by Human Skin Fibroblasts: Immunological Relationship to Other Human IGF-BPs*

1988 • 78 citations

Insulin-Like Growth Factor-I Messenger Ribonucleic Acid in the Developing Human Placenta and in Term Placenta of Diabetics

1988 • 77 citations

Purification and characterization of the receptor for insulin-like growth factor I

1986 • 77 citations

Production of Insulin-Like Growth Factor I and Its Binding Protein in Rat Hepatocytes Cultured from Diabetic and Insulin-Treated Diabetic Rats*

1986 • 77 citations

Mannose 6-phosphate/insulin like growth factor II receptor: The two types of ligands bind simultaneously to one receptor at different sites

1988 • 77 citations

Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II.

1986 • 77 citations

Rat IGF-I cDNA's contain multiple 5′-untranslated regions

1987 • 76 citations

Dual regulation of insulin-like growth factor I expression during renal hypertrophy

1989 • 76 citations

Isolation and NH2-terminal amino acid sequences of rat serum carrier proteins for insulin-like growth factors

1988 • 76 citations

Ontogeny of somatomedin during development in the mouse

1980 • 75 citations

Heterogeneity of insulin‐like growth factor binding proteins between structure and affinity

1987 • 75 citations

Insulin-like growth factor II stimulates production of inositol trisphosphate in proximal tubular basolateral membranes from canine kidney.

1988 • 75 citations

Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.

1984 • 73 citations

EVIDENCE FOR PRODUCTION BY THE LIVER OF TWO IGF BINDING PROTEINS WITH SIMILAR MOLECULAR WEIGHTS BUT DIFFERENT AFFINITIES FOR IGF I AND IGF II. THEIR RELATIONS WITH SERUM AND CEREBROSPINAL FLUID IGF BINDING PROTEINS.

1982 • 73 citations

Activation of a calcium-permeable cation channel by insulin-like growth factor II in BALB/c 3T3 cells

1988 • 73 citations

CHANGES IN THE CIRCULATING FORM OF SERUM SOMATOMEDIN-C DURING FETAL LIFE

1980 • 73 citations

Conductive pathways for HCO3- in basolateral membrane of salamander intestinal cells

1989 • 72 citations

Evidence that type II insulin-like growth factor receptor is coupled to calcium gating system

1988 • 72 citations

Complete characterization of the human IGF‐I nucleotide sequence isolated from a newly constructed adult liver cDNA library

1986 • 72 citations

Structure, Specificity, and Regulation of the Insulin- Like Growth Factor-Binding Proteins in Adult Rat Serum*

1989 • 71 citations

Rat astroglial somatomedin/insulin-like growth factor binding proteins: characterization and evidence of biologic function

1988 • 70 citations

Structural Analogs of Human Insulin-like Growth Factor (IGF) I with Altered Affinity for Type 2 IGF Receptors

1989 • 70 citations

Interactions of insulin, insulinlike growth factor II, and platelet-derived growth factor in erythropoietic culture.

1985 • 70 citations

Serum Half-Life and Biological Activity of Mutants of Human Insulin-Like Growth Factor I which Do Not Bind to Serum Binding Proteins

1988 • 69 citations

Mannose 6-phosphate receptors and their role in targeting proteins to lysosomes

1988 • 69 citations

Demonstration that a Human Hepatoma Cell Line Produces a Specific Insulin-Like Growth Factor Carrier Protein*

1983 • 69 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein from human plasma differs from other human igf binding proteins

1986 • 67 citations

Binding proteins for insulin-like growth factors in adult rat serum. Comparison with other human and rat binding proteins

1987 • 66 citations

Mechanism of insulin action on membrane protein recycling: a selective decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane.

1985 • 66 citations

Biosynthesis of human insulin-like growth factor I (IGF-I). The primary translation product of IGF-I mRNA contains an unusual 48-amino acid signal peptide.

1987 • 65 citations

The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.

1986 • 65 citations

Heterogeneity of insulin-like growth factor-I affinity for the insulin-like growth factor-II receptor: Comparison of natural, synthetic and recombinant DNA-derived insulin-like growth factor-I

1987 • 64 citations

Insulin-Like Growth Factors in Amniotic Fluid*

1984 • 63 citations

Biosynthesis of rat insulin-like growth factor II. I. Immunochemical demonstration of a approximately 20-kilodalton biosynthetic precursor of rat insulin-like growth factor II in metabolically labeled BRL-3A rat liver cells.

1985 • 62 citations

Release of Insulin-Like Growth Factors and Binding Protein Activity into Serum-Free Medium of Cultured Human Fibroblasts*

1984 • 62 citations

Expression of insulin-like growth factor II in human placentas from normal and diabetic pregnancies.

1986 • 61 citations

ANTIBODY AGAINST ACID-STABLE INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN DETECTS 150,000 MOL WT GROWTH HORMONE-DEPENDENT COMPLEX IN HUMAN PLASMA

1985 • 61 citations

Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors

1988 • 61 citations

IGF-II binding on human lymphoid cells: Demonstration of a common high affinity receptor for insulin like peptides

1984 • 60 citations

Effects of inhibitors of N-linked oligosaccharide processing on the biosynthesis and function of insulin and insulin-like growth factor-I receptors.

1988 • 58 citations

Production of IGF-binding proteins by vascular endothelial cells

1987 • 58 citations

Synthesis of Multiplication-Stimulating Activity (Rat Insulin-Like Growth Factor II) by Rat Embryo Fibroblasts*

1983 • 58 citations

Separation of the high affinity insulin-like growth factor I receptor from low affinity binding sites by affinity chromatography.

1987 • 58 citations

Thyroid-stimulating hormone and insulin-like growth factor-1 synergize to elevate 1,2-diacylglycerol in rat thyroid cells. Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems.

1988 • 58 citations

Biologically active domain in somatomedin-binding protein

1986 • 58 citations

Purification of insulin-dependent exocytic vesicles containing the glucose transporter.

1987 • 58 citations

Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit.

1986 • 57 citations

Purification and Immunological Characterization of the Rat Liver Insulin-Like Growth Factor-II Receptor

1987 • 57 citations

Insulin promotes the growth of F9 embryonal carcinoma cells apparently by acting through its own receptor

1982 • 55 citations

Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II.

1988 • 54 citations

Immunological Cross‐reactivity of Multiplication‐Stimulating Activity Polypeptides

1980 • 53 citations

Purification, partial sequences and properties of chicken insulin-like growth factors

1988 • 53 citations

Hormonal stimulation of myoblast differentiation in the absence of DNA synthesis

1982 • 53 citations

Structure of the Human Chromosomal Gene for the 25 Kilodalton Insulin-Like Growth Factor Binding Protein

1989 • 52 citations

Evidence for the role of insulin-like growth factor II (IGF-II) in the control of food intake

1987 • 51 citations

Purification of insulin-like growth factor I receptor from human placental membranes.

1986 • 51 citations

Isolation and partial characterization of six somatomedin-like peptides from human plasma Cohn fraction IV

1986 • 51 citations

Organization of the gene encoding the insulin-like growth factor binding protein IBP-1

1988 • 50 citations

Specific Assay for Insulin-Like Growth Factor (IGF) II Using the IGF Binding Proteins Extracted from Human Cerebrospinal Fluid*

1986 • 50 citations

Structural and Immunological Characterization of Insulin-Like Growth Factor II Binding to IM-9 Cells*

1986 • 49 citations

Reactivation of rat insulin-like growth factor II gene during hepatocarcinogenesis

1988 • 49 citations

Effects of porcine growth hormone and insulin-like growth factor-I (IGF-I) on immunoreactive IGF-binding protein concentration in pigs

1989 • 49 citations

Mannose 6-phosphate-specific receptor is a transmembrane protein with a C-terminal extension oriented towards the cytosol

1985 • 49 citations

Multiplication-stimulating activity-induced alkalinization of canine renal proximal tubular cells.

1986 • 49 citations

Developmentally regulated expression of insulin-like growth factors by differentiated murine teratocarcinomas and extraembryonic mesoderm

1986 • 49 citations

Regulation of Pituitary Insulin-Like Growth Factor-I Messenger Ribonucleic Acid Levels in Rats Harboring Somatomammotropic Tumors: Implications for Growth Hormone Autoregulation*

1988 • 49 citations

Stimulation of Hepatic Insulin-Like Growth Factor-I Gene Expression by Ovine Prolactin: Evidence for Intrinsic Somatogenic Activity in the Rat*

1988 • 49 citations

Cell-Free Synthesis of Rat Insulin-like Growth Factor II

1982 • 48 citations

Somatomedin-C/Insulin-Like Growth Factor I-Binding Proteins in Human Amniotic Fluid and in Fetal and Postnatal Blood: Evidence of Immunological Homology*

1985 • 48 citations

Insulin and insulin-like growth factor 1 stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein in 3T3-L1 adipocytes

1988 • 48 citations

Growth hormone induction of insulin-like growth factor I messenger RNA in primary cultures of rat liver cells

1987 • 48 citations

Developmental Pattern of a Serum Binding Protein for Multiplication Stimulating Activity in the Rat

1982 • 48 citations

Synthesis of Insulin-Like Growth Factor II (IGF-II) in Fetal Rat Tissues: Translation of IGF-II Ribonucleic Acid and Processing of Pre-Pro-IGF-II*

1988 • 46 citations

Complete glycosylation of the insulin and insulin-like growth factor I receptors is not necessary for their biosynthesis and function. Use of swainsonine as an inhibitor in IM-9 cells.

1986 • 46 citations

Alterations in the Synthesis of a Fibroblast Surface Associated 35 K Protein Modulates the Binding of Somatomedin-C/lnsulin-Like Growth Factor I*

1987 • 46 citations

Specific binding of insulin-like growth factors 1 and 2 to the type 1 and type 2 receptors respectively

1988 • 46 citations

Pertussis toxin inhibits the action of insulin-like growth factor-I

1987 • 46 citations

Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor

1986 • 45 citations

Insulin Stimulation of Aminoisobutyric Acid Transport in Human Skin Fibroblasts Is Mediated Through Both Insulin and Type I Insulin-Like Growth Factor Receptors*

1986 • 45 citations

Transmembrane orientation of the mannose 6-phosphate receptor in isolated clathrin-coated vesicles.

1985 • 44 citations

A new leader exon identified in the rat insulin-like growth factor II gene

1987 • 44 citations

Evidence for the Synthesis of a Somatomedin Similar to Insulin‐Like Growth Factor I by Chick Embryo Liver Cells

1980 • 44 citations

Characterization of Multiplication-Stimulating Activity (MSA) carrier protein

1986 • 44 citations

Antiserum Developed for the E Peptide Region of Insulin-Like Growth Factor IA Prohormone Recognizes a Serum Protein by Both Immunoblot and Radioimmunoassay*

1987 • 43 citations

Nutrition and Somatomedin. XIX. Molecular Regulation of Insulin-Like Growth Factor-1 in Streptozotocin-Diabetic Rats

1988 • 43 citations

Structure of the Rat Insulin-Like Growth Factor II Transcriptional Unit: Heterogeneous Transcripts are Generated from Two Promoters by Use of Multiple Polyadenylation Sites and Differential Ribonucleic Acid Splicing

1988 • 43 citations

Functional properties of an isolated .alpha..beta. heterodimeric human placenta insulin-like growth factor 1 receptor complex

1988 • 42 citations

Binding of insulin-like growth Factor ii and multiplication-stimulating activity-stimulated phosphorylation in basolateral membranes from dog kidney.

1984 • 41 citations

Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells

1985 • 41 citations

Elevated concentration of IGF II in brain tissue from an infant with macrencephaly

1986 • 41 citations

Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta.

1988 • 41 citations

Demonstration of Insulin-Like Growth Factor I in Human Urine*

1987 • 40 citations

Insulin-Like Growth Factor Receptors in Rat Placental Membranes*

1984 • 39 citations

Production of insulin‐like growth factor‐II (MSA) by endoderm‐like cells derived from embryonal carcinoma cells: Possible mediator of embryonic cell growth

1985 • 39 citations

Hybrid molecules containing the B-domain of insulin-like growth factor I are recognized by carrier proteins of the growth factor.

1985 • 38 citations

The Insulin-Like Growth Factor II/Mannose-6-Phosphate Receptor Is Present in Monkey Serum

1988 • 38 citations

Biosynthesis of the Low Molecular Weight Carrier Protein for Insulin-Like Growth Factors in Rat Liver and Fibroblasts*

1987 • 37 citations

Circulating insulin-like growth factor-binding proteins in fetal, neonatal and adult sheep

1986 • 37 citations

Transcriptional deviation of the rat insulin-like growth factor II gene initiated at three alternative leader-exons between neonatal tissues and ascites hepatomas

1988 • 36 citations

Phosphorylation of insulin-like growth factor I receptor by the insulin receptor tyrosine kinase in intact cultured skeletal muscle cells

1988 • 36 citations

N-TERMINAL AMINO ACID SEQUENCE OF HUMAN PREGNANCY-ASSOCIATED ENDOMETRIAL α-GLOBULIN, AN ENDOMETRIAL INSULINLIKE GROWTH FACTOR (IGF) BINDING PROTEIN - EVIDENCE FOR TWO SMALL MOLECULAR WEIGHT IGF BINDING PROTEINS*

1988 • 34 citations

Covalent cross-linking of insulin-like growth factor-1 to a specific inhibitor from human serum

1986 • 34 citations

Specificity of tyrosine protein kinases of the structurally related receptors for insulin and insulin-like growth factor I: Tyr-containing synthetic polymers as specific inhibitors or substrates

1988 • 34 citations

Binding of nonsuppressible insulin‐like activity (NSILA) to isolated fat cells: Evidence for two separate membrane acceptor sites

1976 • 33 citations

Expression of a synthetic gene encoding human insulin-like growth factor I in cultured mouse fibroblasts.

1987 • 33 citations

Biosynthesis and processing of the type II insulin-like growth factor receptor in H-35 hepatoma cells.

1985 • 33 citations

Characterization of the insulin-like growth factor (IGF) receptor hi K562 erythroleukemia cells; evidence for a biological function for the type II IGF receptor

1988 • 33 citations

A new 5′‐non‐coding region for human placental insulin‐like growth factor II mRNA expression

1987 • 32 citations

Vanadate stimulation of IGF binding to rat adipocytes

1986 • 29 citations

CONTROL OF IGF-II mRNA LEVELS BY GLUCOCORTICOIDS IN THE NEONATAL RAT

1988 • 29 citations

Characterization of Insulin-Like Growth Factor I Receptors on Human Erythroleukemia Cell Line (K-562 Cells)

1987 • 28 citations

Identification of a peptide fragment from the carboxyl-terminal extension region (E-domain) of rat proinsulin-like growth factor-II.

1985 • 28 citations

Characterization of the stimulatory action of insulin on insulin-like growth factor II binding to rat adipose cells. Differences in the mechanism of insulin action on insulin-like growth factor II receptors and glucose transporters.

1988 • 27 citations

Synthesis of somatomedin C/insulin-like growth factor I by human placenta

1986 • 27 citations

Purification of the serum acid-stable insulin-like growth factor binding protein from the pig (Sus scrofa)

1989 • 26 citations

The specificity of the human IGF-2 receptor

1987 • 26 citations

Expression of insulin‐like growth factor‐I and ‐II genes in rat medullary thyroid carcinoma

1987 • 26 citations

Placental protein 12 (PP12) in primary liver cancer and cirrhosis.

1984 • 25 citations

Specificity of insulin-like growth factor binding to type-II IGF receptors in rabbit mammary gland and hypophysectomized rat liver

1987 • 25 citations

The binding sites of insulin-like growth factor I (IGF I) to type I IGF receptor and to a monoclonal antibody. Mapping by chemical modification of tyrosine residues.

1988 • 24 citations

E-Domain Peptide of Rat Proinsulin-Like Growth Factor-II: Validation of a Radioimmunoassay and Measurement in Culture Medium and Rat Serum*

1987 • 24 citations

Biosynthesis of rat insulin-like growth factor II. II. Localization of mature rat insulin-like growth factor II (7484 daltons) to the amino terminus of the approximately 20-kilodalton biosynthetic precursor by radiosequence analysis.

1985 • 21 citations

Disulphide reduction alters the immunoreactivity and increases the affinity of insulin-like growth-factor-I receptors in human placenta

1986 • 20 citations

In vivoEffects of the Insulin-Like Growth Factors (IGFs) in the Hypophysectomized Rat: Comparison with Human Growth Hormone and the Possible Role of the Specific IGF Carrier Proteins

1985 • 19 citations

Hybrid molecules containing the A-domain of insulin-like growth factor-I and the B-chain of insulin have increased mitogenic activity relative to insulin

1987 • 19 citations

Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer

1986 • 19 citations

Somatomedin C/Insulin-Like Growth Factor 1: An Intratesticular Differentiative Factor of Leydig Cells?

1987 • 18 citations

Fetal Sheep Serum Contains a High Molecular Weight Insulin-Like Growth Factor (IGF) Binding Protein that Is Acid Stable and Specific for IGF-II*

1987 • 17 citations

Insulin induces chloroquine-sensitive recycling of insulin-like growth factor II receptors but not of glucose transporters in rat adipocytes.

1987 • 16 citations

Cell-free synthesis of rat insulin-like growth factor II

1982 • 15 citations

Cholecystokinin and insulin regulate insulin-like growth factor II binding to pancreatic receptors; Evidence of a role for intracellular calcium

1984 • 15 citations

Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain.

1987 • 13 citations

Differential regulation of insulin-like growth factor-II receptors in rathepatocytes and hepatoma cells

1988 • 13 citations

Separation of the Insulin-Like Growth Factor-Binding Proteins in Plasma and Purification of the Larger Molecular Weight Species*

1987 • 12 citations

A novel transcription unit within the exon sequence of the rat insulin like growth factor II gene.

1989 • 12 citations

Protein Phosphorylation and Growth Control

1985 • 11 citations

Tyrosine phosphorylation of the receptor for insulin-like growth factor II is inhibited in plasma membranes from insulin-treated rat adipocytes

1988 • 8 citations

Central nervous system inhibition of pentagastrin-stimulated acid secretion by insulin-like growth factor II

1988 • 8 citations

High-affinity receptor for insulin-like growth factor II in rat liver: properties and regulation in vivo

1987 • 7 citations

Insulin-Like Growth Factors in Fetal Growth

1988 • 4 citations

Organization and Expression of the Genes Encoding the Human Somatomedins

1988 • 3 citations