Tissue and Development Specific Regulation of a Complex Family of Rat Insulin-Like Growth Factor I Messenger Ribonucleic Acids

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new method for sequencing DNA.

1977 • 7,941 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

1986 • 371 citations

SEQUENCE ANALYSIS OF SOMATOMEDIN-C: CONFIRMATION OF IDENTITY WITH INSULIN-LIKE GROWTH FACTOR I

1983 • 297 citations

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

1987 • 292 citations

Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene.

1987 • 279 citations

Molecular Cloning of Rat Insulin-Like Growth Factor I Complementary Deoxyribonucleic Acids: Differential Messenger Ribonucleic Acid Processing and Regulation by Growth Hormone in Extrahepatic Tissues

1987 • 275 citations

Measurement of Somatomedin-Related Peptides in Fetal, Neonatal, and Maternal Rat Serum by Insulin-Like Growth Factor (IGF) I Radioimmunoassay, IGF-II Radioreceptor Assay (RRA), and Multiplication- Stimulating Activity RRA after Acid-Ethanol Extraction*

1982 • 270 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Identification, Characterization, and Regulation of a Rat Complementary Deoxyribonucleic Acid which Encodes Insulin-Like Growth Factor-I*

1987 • 241 citations

Distribution and Regulation of Rat Insulin-Like Growth Factor I Messenger Ribonucleic Acids Encoding Alternative Carboxyterminal E-Peptides: Evidence for Differential Processing and Regulation in Liver

1988 • 224 citations

Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors

1986 • 215 citations

Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor.

1985 • 196 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Growth Hormone Dependence of Somatomedin-C/lnsulin-Like Growth Factor-I and Insulin-Like Growth Factor-ll Messenger Ribonucleic Acids*

1987 • 186 citations

The human insulin‐like growth factor II gene contains two development‐specific promoters

1987 • 170 citations

Hormonal Regulation of the Peripubertal Surge of Insulin-Like Growth Factor-I in the Rat*

1987 • 135 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

Isolation of Rat Testis cDNAs Encoding an Insulin-Like Growth Factor I Precursor

1987 • 105 citations

Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region

1987 • 85 citations

Rat IGF-I cDNA's contain multiple 5′-untranslated regions

1987 • 76 citations

Biosynthesis of human insulin-like growth factor I (IGF-I). The primary translation product of IGF-I mRNA contains an unusual 48-amino acid signal peptide.

1987 • 65 citations

Serum Levels of Immunoreactive Somatomedin A in the Rat: Some Developmental Aspects*

1980 • 53 citations