Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes

1981 • 1,265 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

The Alu Family of Dispersed Repetitive Sequences

1982 • 611 citations

Insulin-like growth factor I stimulates growth in hypophysectomized rats

1982 • 605 citations

Sequence of the human insulin gene

1980 • 553 citations

Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*

1983 • 447 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Novel bacteriophage lambda cloning vector.

1980 • 404 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Hormone families: pancreatic hormones and homologous growth factors

1980 • 375 citations

Hormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts

1981 • 323 citations

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1984 • 281 citations

"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method.

1982 • 279 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Construction of coliphage lambda Charon vectors with BamHI cloning sites

1980 • 230 citations

Structure of a genomic clone encoding biologically active human relaxin

1983 • 227 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

1984 • 180 citations

A New Method for Purifying Lambda DNA From Phage Lysates

1985 • 178 citations

Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe.

1984 • 177 citations

Activation of nif gene expression in Azotobacter by the nifA gene product of Klebsiella pneumoniae

1983 • 76 citations

Release of Insulin-Like Growth Factors and Binding Protein Activity into Serum-Free Medium of Cultured Human Fibroblasts*

1984 • 62 citations

Partial characterization of a mitogenic factor with somatomedin-like activity produced by culture WI-38 human fibroblasts

1981 • 42 citations

The molecular genetics of hemophilia: Blood clotting factors VIII and IX

1985 • 29 citations

Divergence of Binding Sites, in Vitro Action, and Secretory Regulation of the Somatomedin Peptides, IGF-I and IGF-II

1982 • 29 citations