Insulin-Like Growth Factors in Fetal Growth

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

1981 • 595 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.

1986 • 524 citations

Hormonal Proteins and Peptides

1979 • 428 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

1986 • 371 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1984 • 281 citations

Molecular Cloning of Rat Insulin-Like Growth Factor I Complementary Deoxyribonucleic Acids: Differential Messenger Ribonucleic Acid Processing and Regulation by Growth Hormone in Extrahepatic Tissues

1987 • 275 citations

Measurement of Somatomedin-Related Peptides in Fetal, Neonatal, and Maternal Rat Serum by Insulin-Like Growth Factor (IGF) I Radioimmunoassay, IGF-II Radioreceptor Assay (RRA), and Multiplication- Stimulating Activity RRA after Acid-Ethanol Extraction*

1982 • 270 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblasts

1983 • 269 citations

Cross-reaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid

1984 • 266 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues.

1987 • 240 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors

1986 • 215 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

Hormonal Proteins and Peptides

1983 • 205 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Levels of Insulin-like Growth Factors I and II in Human Cord Blood*

1983 • 187 citations

Growth Hormone Dependence of Somatomedin-C/lnsulin-Like Growth Factor-I and Insulin-Like Growth Factor-ll Messenger Ribonucleic Acids*

1987 • 186 citations

Biphasic concentration dependency of stimulation of myoblast differentiation by somatomedins

1986 • 179 citations

Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.

1986 • 174 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

The human insulin‐like growth factor II gene contains two development‐specific promoters

1987 • 170 citations

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

1986 • 166 citations

Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors.

1987 • 165 citations

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

1985 • 164 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

Preferential enhancement of myoblast differentiation by insulin‐like growth factors (IGF I and IGF II) in primary cultures of chicken embryonic cells

1983 • 159 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

An Autocrine/Paracrine Role forInsulin-Like Growth Factors inthe Regulation ofHuman Placental Growth*

1986 • 133 citations

Insulin-like growth factors (IGF) 1 and 2 in human foetal plasma and relationship to gestational age and foetal size during midpregnancy

1985 • 126 citations

Human fetal and adult chondrocytes. Effect of insulinlike growth factors I and II, insulin, and growth hormone on clonal growth.

1986 • 125 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

Immunoassay of a Somatomedin-Binding Protein from Human Amniotic Fluid: Levels in Fetal, Neonatal, and Adult Sera*

1984 • 120 citations

Ontogeny of Receptors for Insulin-Like Peptides in Chick Embryo Tissues: Early Dominance of Insulin-Like Growth Factor over Insulin Receptors in Brain*

1985 • 116 citations

A NOVEL ROLE FOR SOMATOMEDIN-C IN THE CYTODIFFERENTIATION OF THE OVARIAN GRANULOSA CELL

1984 • 111 citations

Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor

1984 • 105 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

Tissue and Plasma Somatomedin-C/Insulin-Like Growth Factor I Concentrations in the Human Fetus during the First Half of Gestation

1986 • 102 citations

Characterization of a somatomedin (insulin-like growth factor) synthesized by fetal rat liver organ cultures.

1979 • 100 citations

Insulin-Like Growth Factor Carrier Proteins in Neonatal and Adult Rat Serum Are Immunologically Different: Demonstration Using a New Radioimmunoassay for the Carrier Protein from BRL-3A Rat Liver Cells

1986 • 96 citations

A new candidate for the regulation of erythropoiesis

1982 • 91 citations

Organization of the human genes for insulin‐like growth factors I and II

1986 • 88 citations

Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II.

1986 • 77 citations

CHANGES IN THE CIRCULATING FORM OF SERUM SOMATOMEDIN-C DURING FETAL LIFE

1980 • 73 citations

Receptors for Insulin-Like Growth Factors and Growth Effects of Multiplication-Stimulating Activity (Rat Insulin-Like Growth Factor II) in Rat Embryo Fibroblasts*

1983 • 64 citations

Insulin-Like Growth Factors in Amniotic Fluid*

1984 • 63 citations

Biosynthesis of rat insulin-like growth factor II. I. Immunochemical demonstration of a approximately 20-kilodalton biosynthetic precursor of rat insulin-like growth factor II in metabolically labeled BRL-3A rat liver cells.

1985 • 62 citations

Affinity-Labeled Somatomedin-C Receptors and Binding Proteins from the Human Fetus*

1984 • 62 citations

Synthesis of Multiplication-Stimulating Activity (Rat Insulin-Like Growth Factor II) by Rat Embryo Fibroblasts*

1983 • 58 citations

Serum Levels of Immunoreactive Somatomedin A in the Rat: Some Developmental Aspects*

1980 • 53 citations

Somatomedin-C in Human Fetal Pancreas: Cellular Localization and Release During Organ Culture

1987 • 50 citations

Developmentally regulated expression of insulin-like growth factors by differentiated murine teratocarcinomas and extraembryonic mesoderm

1986 • 49 citations

Cell-Free Synthesis of Rat Insulin-like Growth Factor II

1982 • 48 citations

Developmental Pattern of a Serum Binding Protein for Multiplication Stimulating Activity in the Rat

1982 • 48 citations

Fetal Rat Myoblasts Release Both Rat Somatomedin-C (SM-C)/Insulin-Like Growth Factor I (IGF I) and Multiplication-Stimulating Activityin Vitro: Partial Characterization and Biological Activity of Myoblast-Derived SM-C/IGF I*

1985 • 47 citations

Evidence for the Synthesis of a Somatomedin Similar to Insulin‐Like Growth Factor I by Chick Embryo Liver Cells

1980 • 44 citations

Production of insulin‐like growth factor‐II (MSA) by endoderm‐like cells derived from embryonal carcinoma cells: Possible mediator of embryonic cell growth

1985 • 39 citations

Biosynthesis of the Low Molecular Weight Carrier Protein for Insulin-Like Growth Factors in Rat Liver and Fibroblasts*

1987 • 37 citations

Synthesis of somatomedin C/insulin-like growth factor I by human placenta

1986 • 27 citations

Somatomedin-C in human fetal pancreas. Cellular localization and release during organ culture

1987 • 26 citations

Multiplication-Stimulating Activity Stimulates the Multiplication of F9 Embryonal Carcinoma Cells*

1982 • 24 citations

E-Domain Peptide of Rat Proinsulin-Like Growth Factor-II: Validation of a Radioimmunoassay and Measurement in Culture Medium and Rat Serum*

1987 • 24 citations

Biosynthesis of rat insulin-like growth factor II. II. Localization of mature rat insulin-like growth factor II (7484 daltons) to the amino terminus of the approximately 20-kilodalton biosynthetic precursor by radiosequence analysis.

1985 • 21 citations

Cell-free synthesis of rat insulin-like growth factor II

1982 • 15 citations

In vitro effect of multiplication stimulating activity (MSA) on human fetal and postnatal cartilage

1986 • 5 citations

MULTIPLICATION STIMULATING ACTIVITY FOR CELLS IN CULTURE

1983 • 4 citations