Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions

1980 • 556 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

The insulin-mimetic effects of vanadate in isolated rat adipocytes. Dissociation from effects of vanadate as a (Na+-K+)ATPase inhibitor.

1980 • 392 citations

A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.

1984 • 351 citations

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

1982 • 287 citations

The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition.

1979 • 282 citations

Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells

1979 • 239 citations

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.

1983 • 223 citations

Characterization of the insulin receptor kinase purified from human placental membranes.

1983 • 196 citations

The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes.

1979 • 196 citations

Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane.

1984 • 169 citations

Defect in Phosphorylation of Insulin Receptors in Cells from an Insulin-Resistant Patient with Normal Insulin Binding

1984 • 167 citations

Hexose Transport in Isolated Brown Fat Cells

1974 • 159 citations

Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

1985 • 155 citations

Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro.

1985 • 151 citations

Protein kinase activity of the insulin receptor

1986 • 149 citations

Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance.

1984 • 146 citations

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.

1986 • 142 citations

Differential effects of sulfhydryl reagents on activation and deactivation of the fat cell hexose transport system.

1976 • 132 citations

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

1983 • 132 citations

Characterization of rat liver endosomal fractions. In vivo activation of insulin-stimulable receptor kinase in these structures.

1986 • 107 citations

Effects of Insulin-Like Growth Factors on Adult Male Rat Pituitary Function in Tissue Culture*

1984 • 106 citations

The insulin receptor of rat brain is coupled to tyrosine kinase activity.

1984 • 106 citations

Vanadate-stimulated NADH oxidation in plasma membrane

1981 • 103 citations

Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo.

1986 • 97 citations

Insulin Receptors in Hepatocytes: Postreceptor Events Mediate Down Regulation

1980 • 88 citations

Insulin-like effect of trypsin on the phosphorylation of rat adipocyte insulin receptor.

1983 • 86 citations

Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor.

1984 • 85 citations

Tyrosine phosphorylation of insulin receptor beta subunit activates the receptor tyrosine kinase in intact H-35 hepatoma cells.

1986 • 75 citations

Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin.

1980 • 73 citations

Alterations in the tyrosine kinase activity of the insulin receptor produced by in vitro hyperinsulinemia.

1986 • 71 citations

Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor.

1984 • 67 citations

The binding of vanadium (V) oligoanions to sarcoplasmic reticulum

1985 • 65 citations

Evidence that amiloride antagonises insulin‐stimulated protein phosphorylation by inhibiting protein kinase activity

1983 • 60 citations

The transport and accumulation of oxyvanadium compounds in human erythrocytes in vitro.

1982 • 47 citations

Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line.

1984 • 39 citations

Vanadate stimulation of IGF binding to rat adipocytes

1986 • 29 citations

Counterregulatory control of intracellular hydrogen peroxide production by insulin and lipolytic hormones in isolated rat epididymal fat cells: a role of free fatty acids

1982 • 28 citations

The role of H2O2 formation in the insulin-like and insulin antagonistic effects on fat cells of ω-aminoalkyl glycosides

1979 • 28 citations