Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects.

In vitro selection of RNA molecules that bind specific ligands

1990 • 9,093 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

1991 • 3,211 citations

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1983 • 2,604 citations

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1992 • 2,361 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

1987 • 1,275 citations

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1990 • 1,270 citations

Tat-mediated delivery of heterologous proteins into cells.

1994 • 1,203 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Site-Specific Oligonucleotide Binding Represses Transcription of the Human c- myc Gene in Vitro

1988 • 707 citations

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

1990 • 663 citations

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

1987 • 660 citations

Autolytic Processing of Dimeric Plant Virus Satellite RNA

1986 • 625 citations

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

1992 • 609 citations

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo

1992 • 548 citations

Antisense and Antigene Properties of Peptide Nucleic Acids

1992 • 538 citations

Nomenclature for incompletely specified bases in nucleic acid sequences: rcommendations 1984

1985 • 537 citations

Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation

1991 • 530 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Sequence requirements of the hammerhead RNA self-cleavage reaction

1990 • 466 citations

SMALL CATALYTIC RNAs

1992 • 455 citations

Directed Evolution of an RNA Enzyme

1992 • 451 citations

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

1990 • 437 citations

Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles

1990 • 424 citations

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

1993 • 420 citations

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

1989 • 416 citations

[20] Computer prediction of RNA structure

1989 • 387 citations

Regulation of Gene Expression with Double-Stranded Phosphorothioate Oligonucleotides

1990 • 373 citations

Intracellular distribution of microinjected antisense oligonucleotides.

1991 • 362 citations

RNA catalytic properties of the minimum (-)sTRSV sequence

1989 • 360 citations

A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA

1993 • 330 citations

Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.

1987 • 329 citations

Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site

1987 • 323 citations

Non-enzymatic cleavage and ligation of RNAs complementary to a plant virus satellite RNA

1986 • 321 citations

Purification and Properties of a Specific Escherichia coli Ribonuclease which Cleaves a Tyrosine Transfer Ribonucleic Acid Precursor

1972 • 318 citations

External Guide Sequences for an RNA Enzyme

1990 • 303 citations

Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels.

1991 • 299 citations

Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture.

1989 • 296 citations

The Tetrahymena ribozyme acts like an RNA restriction endonuclease

1986 • 285 citations

Triple Helix-Specific Ligands

1992 • 281 citations

Model Substrates for an RNA Enzyme

1987 • 264 citations

HUMAN GENE THERAPY

1993 • 262 citations

A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction

1994 • 261 citations

In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

1993 • 261 citations

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

1988 • 251 citations

Triple helix formation by oligonucleotides on DNA extended to the physiological pH range

1989 • 246 citations

Specific inhibition of transcription by triple helix-forming oligonucleotides.

1992 • 241 citations

Binding of triple helix forming oligonucleotides to sites in gene promoters

1991 • 240 citations

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

1990 • 238 citations

An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis.

1994 • 234 citations

‘Hairpin’ catalytic RNA model: evidence for helices and sequence requirement for substrate RNA

1990 • 232 citations

Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein

1990 • 229 citations

Sequence-specific photo-induced cross-linking of the two strands of double-helical DNA by a psoralen covalently linked to a triple helix-forming oligonucleotide.

1991 • 224 citations

Ribozyme mediated destruction of RNA in vivo.

1989 • 223 citations

A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1.

1993 • 223 citations

Kinetics and thermodynamics of triple-helix formation: effects of ionic strength and mismatched

1992 • 222 citations

Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.

1991 • 222 citations

Oligonucleotide analogues as potential chemotherapeutic agents.

1988 • 221 citations

Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.

1992 • 220 citations

Tethering Ribozymes to a Retroviral Packaging Signal for Destruction of Viral RNA

1993 • 213 citations

Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.

1991 • 211 citations

Human Gene Therapy

1992 • 206 citations

Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides

1990 • 200 citations

Protein Enhancement of Hammerhead Ribozyme Catalysis

1993 • 199 citations

The single-stranded DNA aptamer-binding site of human thrombin.

1993 • 192 citations

Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme.

1993 • 189 citations

Oligonucleotide inhibition of IL2Rα mRNA transcription by promoter region collinear triplex formation in lymphocytes

1991 • 183 citations

Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.

1989 • 177 citations

Amplification, mutation and selection of catalytic RNA

1989 • 176 citations

Two sequences participating in the autolytic processing of satellite tobacco ringspot virus comple- mentary RNA

1989 • 176 citations

Triple helix formation inhibits transcription elongation in vitro.

1991 • 171 citations

Specific gene suppression by engineered ribozymes in monkey cells.

1989 • 171 citations

Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA

1990 • 170 citations

A triple helix-forming oligonucleotide-intercalator conjugate acts as a transcriptional repressor via inhibition of NF kappa B binding to interleukin-2 receptor alpha-regulatory sequence.

1992 • 169 citations

Sequence specificity in triple helix formation: experimental and theoretical studies of the effect of mismatches on triplex stability

1991 • 167 citations

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

1990 • 167 citations

Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1.

1992 • 165 citations

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.

1990 • 157 citations

Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme

1991 • 156 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Inhibition of gene expression by triple helix-directed DNA cross-linking at specific sites.

1993 • 154 citations

Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication.

1990 • 151 citations

Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides.

1992 • 150 citations

Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.

1989 • 148 citations

Targeted cleavage of mRNA by human RNase P.

1992 • 148 citations

Using RNAFOLD to predict the activity of small catalytic RNAs.

1993 • 148 citations

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cells

1989 • 147 citations

Triplex formation of oligonucleotides containing 2'-O-methylpseudoisocytidine in substitution for 2'-deoxycytidine

1991 • 146 citations

Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1.

1994 • 146 citations

Sequences required for self-catalysed cleavage of the satellite RNA of tobacco ringspot virus

1989 • 143 citations

Novel guanosine requirement for catalysis by the hairpin ribozyme

1991 • 142 citations

Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line

1993 • 141 citations

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

1990 • 140 citations

Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication—potential effectiveness against most presently sequenced HIV-1 isolates

1992 • 139 citations

Inhibition of transcription of HIV-1 in infected human cells by oligodeoxynucleotides designed to form DNA triple helices.

1992 • 136 citations

Site-specific inhibition ofEcoRI restriction/modification enzymes by a DNA triple helix

1990 • 135 citations

In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions.

1992 • 134 citations

Can hammerhead ribozymes be efficient tools to inactivate gene function?

1994 • 133 citations

Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS.

1993 • 133 citations

Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides

1989 • 133 citations

Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression

1992 • 127 citations

Design of a nonnatural deoxyribonucleoside for recognition of GC base pairs by oligonucleotide-directed triple helix formation

1992 • 127 citations

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages

1993 • 124 citations

Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis .delta. virus RNA sequence

1992 • 120 citations

Inhibition of Simian Virus 40 DNA replication in CV-1 cells by an oligodeoxynucleotide covalently linked to an intercalating agent

1990 • 119 citations

Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme.

1994 • 118 citations

DNA triple-helix specific intercalators as antigene enhancers: Unfused aromatic cations

1993 • 117 citations

Reversal of the Malignant Phenotype by an Anti-ras Ribozyme

1992 • 117 citations

Chimeric DNA-RNA hammerhead ribozymes have enhancedin vitrocatalytic efficiency and increased stabilityin vivo

1992 • 116 citations

Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA

1992 • 115 citations

Cleavage of specific sites of RNA by designed ribozymes

1988 • 113 citations

Reversal of drug sensitivity in multidrug-resistant tumor cells by an MDR1 (PGY1) ribozyme.

1994 • 112 citations

Construction of a series of several self‐cleaving RNA duplexes using synthetic 21‐mers

1988 • 112 citations

Prevention of human immunodeficiency virus type 1 integrase expression in Escherichia coli by a ribozyme.

1991 • 112 citations

Localized RNAs and their functions

1993 • 110 citations

Preformed ribozyme destroys tumour necrosis factor mRNA in human cells

1992 • 107 citations

Mutagenesis of the hairpin ribozyme

1994 • 105 citations

Ionic requirements for RNA binding, cleavage, and ligation by the hairpin ribozyme

1993 • 104 citations

A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus‐specific proteins in MDCK cells

1990 • 103 citations

Delivery of c-myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Correlates with Inhibition of Cell Growth and DNA Synthesis

1988 • 102 citations

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila

1993 • 101 citations

Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1.

1994 • 100 citations

Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates.

1993 • 100 citations

Expression of a chimeric ribozyme gene results in endonucleolytic cleavage of target mRNA and a concomitant reduction of gene expression in vivo.

1992 • 100 citations

Inhibition of HIV-1 replication by ribozymes that show poor activityin vitro

1993 • 99 citations

Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth.

1994 • 95 citations

Binding and cleavage of nucleic acids by the "hairpin" ribozyme

1991 • 95 citations

Triple-helix formation by alpha oligodeoxynucleotides and alpha oligodeoxynucleotide-intercalator conjugates.

1991 • 94 citations

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

1993 • 93 citations

Secondary structure of the self-cleaving RNA of hepatitis delta virus: applications to catalytic RNA design

1992 • 93 citations

Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1

1993 • 92 citations

In vivotranscription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide

1993 • 92 citations

Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates

1992 • 90 citations

A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules essential for catalytic function of the hairpin ribozyme

1994 • 89 citations

Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices

1992 • 88 citations

Cytoplasmic delivery of ribozymes leads to efficient reduction in alpha-lactalbumin mRNA levels in C127I mouse cells.

1992 • 88 citations

Liposomes as a Drug Delivery System for Antisense Oligonucleotides

1992 • 87 citations

Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme

1994 • 86 citations

Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein

1991 • 85 citations

Optimization of an anti-HIV hairpin ribozyme by in vitro selection.

1993 • 85 citations

Oligonucleotide-mediated triple helix formation using an N3-protonated deoxycytidine analog exhibiting pH-independent binding within the physiological range.

1992 • 83 citations

Ribozymes correctly cleave a model substrate and endogenous RNA in vivo.

1990 • 82 citations

Oligonucleotide clamps arrest DNA synthesis on a single-stranded DNA target.

1993 • 82 citations

Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2′-O-methylation

1992 • 78 citations

Four ribose 2'-hydroxyl groups essential for catalytic function of the hairpin ribozyme.

1993 • 78 citations

Characterization of a Triple Helix-specific Ligand

1993 • 77 citations

Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro.

1989 • 74 citations

In vitro and in vivo pharmacologic activities of antisense oligonucleotides.

1991 • 73 citations

Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template

1992 • 71 citations

Modulation of oligonucleotide duplex and triplex stability via hydrophobic interactions

1993 • 69 citations

Reduced β2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme

1994 • 69 citations

Ribozymes that cleave an RNA sequence from human immunodeficiency virus: The effect of flanking sequence on rate

1991 • 66 citations

Ribozyme-mediated cleavage of the BCRABL oncogene transcript: in vitro cleavage of RNA and in vivo loss of P210 protein-kinase activity.

1993 • 65 citations

Ribozymes which cleave arenavirus RNAs: identification of susceptible target sites and inhibition by target site secondary structure

1992 • 65 citations

A circular trans-acting hepatitis delta virus ribozyme

1993 • 64 citations

In vitro and in vivo effects of synthetic ribozymes targeted against BCR/ABL mRNA.

1993 • 63 citations

Inhibition of T7 RNA polymerase initiation by triple-helical DNA complexes: a model for artificial gene repression

1992 • 63 citations

Effective incorporation of 2'-O-methyl-oligoribonuclectides into liposomes and enhanced cell association through modification with thiocholesterol

1992 • 63 citations

7,8-Dihydro-8-oxoadenine as a replacement for cytosine in the third strand of triple helixes. Triplex formation without hypochromicity

1993 • 62 citations

The new frontier: gene and oligonucleotide therapy

1994 • 61 citations

Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene

1992 • 60 citations

OligonucleotJde-directed triple helix formation at adjacent oligopurine and oligopyrimidine DNA tracts by alternate strand recognition

1992 • 60 citations

Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation.

1993 • 59 citations

Evolutionary Optimization of the Catalytic Properties of a DNA-Cleaving Ribozyme

1994 • 58 citations

A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability

1992 • 58 citations

In vitro selection and evolution of RNA: applications for catalytic RNA, molecular recognition, and drug discovery.

1993 • 57 citations

Ribozyme mediated destruction of influenza A virus in vitro and in vivo

1994 • 57 citations

Extensive phosphorothioate substitution yields highly active and nuclease-resistant hairpin ribozymes

1992 • 57 citations

Rational Design of Self-Cleaving pre-tRNA-Ribonuclease P RNA Conjugates

1994 • 56 citations

Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter.

1992 • 56 citations

Ribozyme cleaves rex/tax mRNA and inhibits bovine leukemia virus expression.

1993 • 56 citations

Targeted delivery of antisense oligonucleotides by molecular conjugates

1992 • 53 citations

Triple Helix Formation with Short Oligonucleotide-Intercalator Conjugates Matching the HIV-1 U3 LTR End Sequence

1994 • 51 citations

The utility of an antifos ribozyme in reversing cisplatin resistance in human carcinomas

1992 • 51 citations

Selective cleavage ofbcr-ablchimeric RNAs by a ribozyme targeted to non-contiguous sequences

1994 • 49 citations

Intramolecular triplex potential sequence within a gene down regulates its expressionin vivo

1992 • 49 citations

Antisense Catalytic RNAs as Therapeutic Agents

1994 • 47 citations

Reversible inhibition of gene expression by a psoralen functionalized triple helix forming oligonucleotide in intact cells

1994 • 47 citations

Design and specificity of hammerhead ribozymes against calretinin mRNA

1993 • 47 citations

AUA-Cleaving Hammerhead Ribozymes: Attempted Selection for Improved Cleavage

1994 • 45 citations

Inhibition of gene transcription by purine rich triplex forming oligodeoxyribonucleotides

1993 • 45 citations

Detailed study of sequence-specific DNA cleavage of triplex-forming oligonucleotides linked to 1,10-phenanthroline

1994 • 44 citations

Specific association between an endoribonucleolytic sequence from a satellite RNA and a substrate analogue containing a 2'-5' phosphodiester.

1990 • 41 citations

Ribozyme-mediated cleavage of the bcr/abl transcript expressed in chronic myeloid leukemia.

1993 • 41 citations

Extension of the range of recognition sequences for triple helix formation by oligonucleotides containing guanines and thymines.

1991 • 40 citations

Evidence for spontaneous circle formation in the replication of the satellite RNA of tobacco ringspot virus

1991 • 38 citations

An anti-lymphocytic choriomeningitis virus ribozyme expressed in tissue culture cells diminishes viral RNA levels and leads to a reduction in infectious virus yield

1993 • 38 citations

Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs

1994 • 35 citations

Cooperative Binding of 8-mer Oligonucleotides Containing 5-(1-Propynyl)-2'-deoxyuridine to Adjacent DNA Sites by Triple-Helix Formation

1994 • 34 citations

Repression of bacteriophage promoters by DNA and RNA oligonucleotides

1993 • 33 citations

Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides

1994 • 31 citations

Cleavage of full-length βAPP mRNA by hammerhead ribozymes

1993 • 30 citations

The polypurine tract, PPT, of HIV as target for antisense and triple-helix-forming oligonucleotides

1993 • 30 citations

Selection of Antisense Oligonucleotides on the Basis of Genomic Frequency of the Target Sequence

1994 • 30 citations

H‐ras Ribozyme‐Mediated, Alteration of the Human Melanoma Phenotypea

1994 • 29 citations

Inhibition of T7 and T3 RNA polymerase directed transcription elongationin vitro

1994 • 29 citations

Inhibition of Klenow Fragment DNA Polymerase on Double-Helical Templates by Oligonucleotide-Directed Triple-Helix Formation

1994 • 29 citations

Sequence limitations of triple helix formation by alternate-strand recognition

1993 • 29 citations

Development of Antisense Therapeutics: Implications for Cancer Gene Therapy

1994 • 28 citations

A Unique c-myc-Targeted Triplex-Forming Oligonucleotide Inhibits the Growth of Ovarian and Cervical Carcinomas in Vitro

1993 • 27 citations

The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions

1993 • 26 citations

The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex formation

1992 • 24 citations

Cleavage of human MDR1 mRNA by a hammerhead ribozyme

1993 • 24 citations

Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes

1990 • 24 citations

Activation of HIV-specific ribozyme activity by self-cleavage

1993 • 23 citations

Inhibition of c-Ha-ras Gene Expression by Hammerhead Ribozymes Containing a Stable C(UUCG)G Hairpin Loop.

1993 • 22 citations

Ribozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression.

1993 • 21 citations

Selective cleavage of closely-related mRNAs by synthetic ribozymes

1992 • 20 citations

Relief of triple-helix-mediated promoter inhibition by elongating RNA polymerases

1993 • 17 citations

Site-Specific Cleavage of natural mRNA sequences by newly designed hairpin catalytic RNAs

1991 • 16 citations

Construction and characterization of lck- and fyn -specific tRNA: Ribozyme chimeras

1994 • 15 citations

In vitro cleavage of HIV-1 vif RNA by a synthetic ribozyme

1991 • 15 citations

Hammerhead ribozyme cleavage of hamster prion pre-mRNA in complex cell-free model systems

1992 • 13 citations

Effect of abasic linker substitution on triplex formation, Sp1 binding, and specificity in an oligonucleotide targeted to the human Ha-raspromoter

1994 • 13 citations

Specificity of ribozyme designed for mutated DHFR mRNA

1994 • 11 citations

Deriving a 67-Nucleotidetrans-Cleaving Ribozyme from the Hepatitis Delta Virus Antigenomic RNA

1992 • 8 citations

Transcriptional inhibition of the bacteriophage T7 early promoter region by oligonucleotide triple helix formation

1992 • 6 citations

Inhibition of Restriction Endonuclease Cleavage Site via Triple Helix Formation by Homopyrimidine Phosphorothioate Oligonucleotides

1993 • 4 citations

Double‐Stranded Phosphorothioate, Oligonucleotide Modulation of Gene Expressiona

1994 • 3 citations

Trans cleavage of RNA substrates by an HDV-derived ribozyme.

1993 • 2 citations

Climate forcing by warm seas

1988 • 2 citations

Deleted Work

1955 • 0 citations