Rational Design of Self-Cleaving pre-tRNA-Ribonuclease P RNA Conjugates

Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.

1990 • 5,831 citations

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

1994 • 3,007 citations

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1983 • 2,604 citations

[5] Synthesis of small RNAs using T7 RNA polymerase

1989 • 1,072 citations

Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases

1988 • 847 citations

Making ends meet: a model for RNA splicing in fungal mitochondria

1982 • 459 citations

[9] Specific labeling of 3′ termini of RNA with T4 RNA ligase

1980 • 421 citations

External Guide Sequences for an RNA Enzyme

1990 • 303 citations

Role of the Protein Moiety of Ribonuclease P, a Ribonucleoprotein Enzyme

1988 • 225 citations

The secondary structure of ribonuclease P RNA, the catalytic element of a ribonucleoprotein enzyme

1988 • 213 citations

Multiple magnesium ions in the ribonuclease P reaction mechanism

1993 • 192 citations

Recent studies of ribonuclease P.

1993 • 177 citations

Mapping the active site of ribonuclease P RNA using a substrate containing a photoaffinity agent.

1990 • 174 citations

Further perspective on the catalytic core and secondary structure of ribonuclease P RNA.

1994 • 127 citations

Influence of metal ions on the ribonuclease P reaction. Distinguishing substrate binding from catalysis.

1992 • 127 citations

Circularly Permuted tRNAs as Specific Photoaffinity Probes of Ribonuclease P RNA Structure

1993 • 104 citations

Ribonuclease P: function and variation.

1990 • 104 citations

The RNA component of the Bacillus subtilis RNase P. Sequence, activity, and partial secondary structure.

1986 • 94 citations

Product release is a rate-limiting step during cleavage by the catalytic RNA subunit ofEscherichia ColiRNase P

1993 • 83 citations

Ribonuclease P RNA and protein subunits from bacteria

1992 • 72 citations

RNA enzymes (ribozymes) as antiviral therapeutic agents

1990 • 70 citations

Reconstitution of enzymatic activity from fragments of M1 RNA.

1992 • 62 citations

Architecture of the U5 small nuclear RNA.

1994 • 60 citations

Protection from chemical modification of nucleotides in complexes of M1 RNA, the catalytic subunit of RNase P from E coli, and tRNA precursors

1990 • 40 citations

Artificial self-cleaving molecules consisting of a tRNA precursor and the catalytic RNA of RNase P

1993 • 16 citations