The single-stranded DNA aptamer-binding site of human thrombin.

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1992 • 2,361 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

1989 • 889 citations

Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.

1993 • 854 citations

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

1990 • 853 citations

Factor XI Activation in a Revised Model of Blood Coagulation

1991 • 774 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

Domains specifying thrombin–receptor interaction

1991 • 553 citations

Mitogenic activity of blood components. I. Thrombin and prothrombin.

1975 • 481 citations

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.

1990 • 362 citations

Monocyte Chemotaxis: Stimulation by Specific Exosite Region in Thrombin

1983 • 333 citations

Phosphoinositides in mitogenesis: Neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation

1985 • 332 citations

A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA

1993 • 330 citations

In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

1993 • 261 citations

Identification of a labelled peptide after stoicheiometric reaction of fluorescein isothiocyanate with the Ca²⁺ -dependent adenosine triphosphatase of sarcoplasmic reticulum

1982 • 260 citations

The amino acid sequence of a fluorescein-labeled peptide from the active site of (Na,K)-ATPase.

1984 • 212 citations

THROMBIN SPECIFICITY*

1981 • 202 citations

Thrombin‐Cellular Interactions

1986 • 202 citations

Anion-binding exosite of human .alpha.-thrombin and fibrin(ogen) recognition

1988 • 161 citations

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

1991 • 129 citations

Structural and functional properties of human α-thrombin, phosphopyridoxylated α-thrombin, and γT-thrombin

1989 • 90 citations

Localization of the single-stranded DNA binding site in the thrombin anion-binding exosite.

1992 • 79 citations

Role of thrombin exosites in inhibition by heparin cofactor II.

1992 • 72 citations

Antithrombin reactions with .alpha.- and .gamma.-thrombins

1979 • 69 citations

The hirudin-binding site of human α-thrombin

1989 • 53 citations

The ATP/AMP binding site of pyruvate, phosphate dikinase: selective modification with fluorescein isothiocyanate

1988 • 7 citations