Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

1977 • 1,311 citations

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

1977 • 1,239 citations

INCREASED VASCULAR PERMEABILITY: A MAJOR CAUSE OF HYPOALBUMINAEMIA IN DISEASE AND INJURY

1985 • 864 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Tumoritropic and lymphotropic principles of macromolecular drugs.

1989 • 576 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

1987 • 450 citations

Effect of molecular weight (M_w) ofN‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

1987 • 428 citations

Antigenicity: Some Molecular Aspects

1969 • 418 citations

Biological approaches to the controlled delivery of drugs: a critical review.

1984 • 348 citations

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report

1983 • 332 citations

Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells.

1991 • 325 citations

The structure of neocarzinostatin chromophore possessing a novel bicyclo-[7,3,0]dodecadiyne system

1985 • 323 citations

Passive tumor targeting of soluble macromolecules and drug conjugates.

1992 • 315 citations

Phase I immunotoxin trial in patients with B-cell lymphoma.

1991 • 289 citations

Molecular structural effects produced in proteins by reaction with succinic anhydride

1958 • 269 citations

A New Approach to Cancer Chemotherapy: Selective Enhancement of Tumor Blood Flow With Angiotensin II<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 268 citations

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

1987 • 248 citations

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies.

1982 • 232 citations

Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium

1984 • 230 citations

Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties

1985 • 221 citations

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycinImmunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

1989 • 196 citations

Disposition and tumor localization of mitomycin C-dextran conjugates in mice.

1987 • 176 citations

Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

1988 • 157 citations

A LIPOPHILIC DERIVATIVE OF NEOCARZINOSTATIN A Polymer Conjugation of an Antitumor Protein Antibiotic*

1979 • 151 citations

Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium

1985 • 143 citations

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1986 • 133 citations

Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.

1988 • 127 citations

Higher Antitumor Efficacy of Daunomycin When Linked to Dextran: In Vivo and In Vitro Studies 2

1978 • 124 citations

The adjuvant activity of nonionic block polymer surfactants. II. Antibody formation and inflammation related to the structure of triblock and octablock copolymers.

1984 • 122 citations

The pharmacokinetics of polymer-bound adriamycin

1990 • 121 citations

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia

1988 • 119 citations

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1991 • 116 citations

Increased Vascular Permeability in Organs Mediated by the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Mice

1988 • 115 citations

Interferon Induction in Man by a Synthetic Polyanion of Defined Composition

1967 • 113 citations

Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs

1984 • 110 citations

Kinin‐generating Cascade in Advanced Cancer Patients and in vitro Study

1991 • 103 citations

Polymers containing enzymatically degradable bonds, XII. Effect of spacer structure on the rate of release of daunomycin and adriamycin from poly [N-(2-hydroxypropyl)-methacrylamide] copolymer drag carriers in vitro and antitumour activity measured in vivo

1992 • 95 citations

Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol.

1981 • 93 citations

Clinical application of monoclonal antibody-drug conjugates for immunotargeting chemotherapy of colorectal carcinoma

1988 • 92 citations

Specific binding of vascular permeability factor to endothelial cells

1991 • 86 citations

Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy.

1991 • 80 citations

The tumor blood vessel as an ideal target for macromolecular anticancer agents

1992 • 79 citations

Antibody directed enzyme prodrug therapy (ADEPT): clinical report.

1991 • 79 citations

Chemical modification of superoxide dismutase Extension of plasma half life of the enzyme through its reversible binding to the circulating albumin

1988 • 62 citations

Immunogenicity of N-(2-hydroxypropyl) methacrylamide copolymers

1985 • 61 citations

Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities

1987 • 60 citations

Protein Binding of Macromolecular Anticancer Agent SMANCS: Characterization of Poly(styrene-co-maleic acid) Derivatives as an Albumin Binding Ligand

1988 • 59 citations

In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate

1991 • 54 citations

Review : Synthetic Polymers with Intrinsic Anticancer Activity

1991 • 53 citations

Controlled Release of Drug Model from N-(2-Hydroxypropyl)-methacrylamide Copolymers

1985 • 44 citations

Rapid uptake by liver sinusoidal cells of serum albumin modified with retention of its compact conformation

1975 • 43 citations

Synthesis of antitumor‐active conjugates of adriamycin or daunomycin with the copolymer of divinyl ether and maleic anhydride

1986 • 42 citations

Pancreatic Ribonuclease: Enzymic and Physiological Properties of a Cross-Linked Dimer

1974 • 39 citations

Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates

1989 • 39 citations

Control of Pharmaceutical Properties of Soybean Trypsin Inhibitor by Conjugation with Dextran I: Synthesis and Characterization

1989 • 39 citations

Immunogenicity of Protein-N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates in A/J and B10 Mice

1990 • 38 citations

Control of Pharmaceutical Properties of Soybean Trypsin Inhibitor by Conjugation with Dextran II: Biopharmaceutical and Pharmacological Properties

1989 • 37 citations

Stimulation of Macrophage by Polyanions and Its Conjugated Proteins and Effect on Cell Membrane

1986 • 37 citations

Increase in Tumor Vascular Area Due to Increased Blood Flow by Angiotensin II in Rats

1985 • 32 citations

Enhanced Tumor Localization of Monoclonal Antibody by Treatment with Kininase II Inhibitor and Angiotensin II

1992 • 32 citations

Role of natural killer cells and macrophages in the nonspecific resistance to tumors in mice stimulated with SMANCS, a polymer-conjugated derivative of neocarzinostatin.

1990 • 31 citations

Improvement of Pharmacological Properties of Protein-Drugs by Tailoring with Synthetic Polymers

1988 • 30 citations

A New Tactic for the Treatment of Jaundice: An Injectable Polymer-Conjugated Bilirubin Oxidase

1988 • 28 citations

Reexamination of the primary structure of an antitumor protein, neocarzinostatin

1986 • 25 citations

Distribution of doxorubicin to normal breast and tumour tissue in patients undergoing mastectomy

1990 • 24 citations

Interferon induction by SMANCS: a polymer-conjugated derivative of neocarzinostatin.

1988 • 24 citations

Angiotensin II as a potential method of targeting cytotoxic-loaded microspheres in patients with colorectal liver metastases

1991 • 24 citations

Isotype distribution and fine specificity of the antibody response of inbred mouse strains to four compounds belonging to a new group of synthetic branched polypeptides

1986 • 23 citations

Effects of recombinant alpha-interferon-gelatin conjugate on in vivo murine tumor cell growth.

1991 • 23 citations

Role of the Carrier in Development of Delayed Sensitivity to the Azophenyl-Arsonate Group

1965 • 23 citations

The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model

1990 • 22 citations

Targeting Chemotherapy of Hepatocellular Carcinoma

1987 • 22 citations

The preparation of mitomycin C, adriamycin and daunomycin covalently bound to antibodies as improved cancer chemotherapeutic agents.

1981 • 21 citations

Binding and endocytosis of .alpha.2-macroglobulin-plasmin complexes

1985 • 21 citations

Degradation pathway of kinins in tumor ascites and inhibition by kininase inhibitors: Analysis by HPLC

1990 • 19 citations

Antitumor effects of SMANCS on rat mammary tumor induced by 7,12-dimethylbenz[a]anthracene.

1992 • 15 citations

Tumor-targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma

1991 • 15 citations

Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinyl ether-maleic acid copolymer

1990 • 13 citations

Stimulation of non-specific resistance to tumors in the mouse using a poly(maleic-acid-styrene)-conjugated neocarzinostatin

1989 • 12 citations

Location of the disulfide bonds in the antitumor protein neocarzinostatin

1991 • 10 citations

Cytotoxicity of smancs in comparison with other anticancer agents against various cells in culture.

1989 • 10 citations

Pharmacokinetics of adriamycin-oxidized dextran conjugate (ADM-OXD) in experimental animals.

1991 • 9 citations

Selective accumulation of a new antineoplastic agent, K-18 (human immunoglobulin conjugated melphalan), in Ehrlich carcinoma transplanted in mice.

1988 • 2 citations