Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

1990 • 663 citations

Biological Catalysis by RNA

1986 • 496 citations

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1991 • 466 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.

1991 • 211 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Specific gene suppression by engineered ribozymes in monkey cells.

1989 • 171 citations

Nuclease resistant ribozymes with high catalytic activity.

1992 • 148 citations

Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.

1990 • 148 citations

The Biochemistry Of P-Glycoprotein-Mediated Multidrug Resistance

1989 • 132 citations

Reversal of the Malignant Phenotype by an Anti-ras Ribozyme

1992 • 117 citations

RNA synthesis: strategies for the use of bacteriophage RNA polymerases

1988 • 91 citations

The utility of an antifos ribozyme in reversing cisplatin resistance in human carcinomas

1992 • 51 citations

What's New in Cytostatic Drug Resistance and Pathology

1991 • 48 citations

Effectiveness of mitoxantrone on the proliferation of cell cultures derived from malignant mesenchymal tumors of human origin

1988 • 12 citations