Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter.

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Site-Specific Oligonucleotide Binding Represses Transcription of the Human c- myc Gene in Vitro

1988 • 707 citations

The chemistry and biology of unusual DNA structures adopted by oligopurine · oligopyrimidine sequences

1988 • 543 citations

Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation

1991 • 530 citations

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

1989 • 416 citations

Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.

1988 • 315 citations

Unusual DNA structures.

1988 • 309 citations

Single Strands, Triple Strands, and Kinks in H-DNA

1988 • 269 citations

The functional human dihydrofolate reductase gene.

1984 • 245 citations

Molecular Basis of Specificity in Nucleic Acid-Drug Interactions

1990 • 184 citations

The S1-sensitive Form of D(C-T) _n ⋅d(A-G) _n : Chemical Evidence for a Three-Stranded Structure in Plasmids

1988 • 174 citations

Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle.

1985 • 165 citations

Resistance to methotrexate due to gene amplification in a patient with acute leukemia.

1984 • 145 citations

Specificity in formation of triple-stranded nucleic acid helical complexes: studies with agarose-linked polyribonucleotide affinity columns

1988 • 142 citations

Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter

1989 • 123 citations

Cell cycle regulation of dihydrofolate reductase mRNA metabolism in mouse fibroblasts.

1980 • 89 citations

Methotrexate resistance and gene amplification. Mechanisms and implications

1986 • 79 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate

1983 • 60 citations

Effects of estrogen and tamoxifen on the regulation of dihydrofolate reductase gene expression in a human breast cancer cell line.

1985 • 25 citations

5' Nucleotide sequences influence serum-modulated expression of a human dihydrofolate reductase minigene.

1986 • 15 citations