Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

1990 • 663 citations

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

1987 • 660 citations

Autolytic Processing of Dimeric Plant Virus Satellite RNA

1986 • 625 citations

Sequence requirements of the hammerhead RNA self-cleavage reaction

1990 • 466 citations

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1991 • 466 citations

Metal ion catalysis in the Tetrahymena ribozyme reaction

1993 • 386 citations

Role of divalent metal ions in the hammerhead RNA cleavage reaction

1991 • 365 citations

Numbering system for the hammerhead

1992 • 291 citations

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

1991 • 245 citations

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

1990 • 238 citations

Self-cleaving transcripts of satellite DNA from the newt

1987 • 237 citations

Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.

1992 • 220 citations

Kinetics of intermolecular cleavage by hammerhead ribozymes

1992 • 202 citations

RNA splicing in neurospora mitochondria: Self-splicing of a mitochondrial intron in vitro

1984 • 187 citations

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and magnesium binding

1991 • 182 citations

Self-cleavage of RNA in the replication of small pathogens of plants and animals

1989 • 177 citations

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

1990 • 167 citations

Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1.

1992 • 165 citations

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

1990 • 161 citations

RNA as an Enzyme

1986 • 160 citations

Nuclease resistant ribozymes with high catalytic activity.

1992 • 148 citations

Ribonuclease P: An Enzyme with a Catalytic RNA Subunit

1989 • 143 citations

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates)

1991 • 142 citations

Minimal sequence requirements for ribozyme activity.

1992 • 125 citations

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

1991 • 123 citations

Extended target-site specificity for a hammerhead ribozyme

1992 • 119 citations

Chimeric DNA-RNA hammerhead ribozymes have enhancedin vitrocatalytic efficiency and increased stabilityin vivo

1992 • 116 citations

Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain

1992 • 114 citations

Cleavage of specific sites of RNA by designed ribozymes

1988 • 113 citations

Construction of a series of several self‐cleaving RNA duplexes using synthetic 21‐mers

1988 • 112 citations

Prevention of human immunodeficiency virus type 1 integrase expression in Escherichia coli by a ribozyme.

1991 • 112 citations

Evidence for processivity and two-step binding of the RNA substrate from studies of J1/2 mutants of the Tetrahymena ribozyme

1992 • 111 citations

Study of a hammerhead ribozyme containing 2'-modified adenosine residues

1991 • 98 citations

Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications.

1992 • 96 citations

Mutagenesis analysis of a self-cleaving RNA

1989 • 91 citations

Studies on the hammerhead RNA self-cleaving domain

1989 • 81 citations

Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity

1991 • 75 citations

Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.

1992 • 69 citations

Ribozymes that cleave an RNA sequence from human immunodeficiency virus: The effect of flanking sequence on rate

1991 • 66 citations

Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme

1990 • 63 citations

Theoretical analyses on the role of Mg2+ ions in ribozyme reactions.

1993 • 61 citations

A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability

1992 • 58 citations

Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding

1992 • 55 citations

Energetics of RNA cleavage: implications for the mechanism of action of ribozymes

1990 • 38 citations

Oligonucleotides and Analogues: A Practical Approach

1992 • 30 citations

Preferential chelation of cationic ligands to axial-equatorial oxygens over equatorial-equatorial dianionic oxygens: implication to the mechanism of action of ribozymes.

1991 • 5 citations

Activities of HIV-RNA targeted ribozymes transcribed from a 'shot-gun' type ribozyme-trimming plasmid.

1992 • 4 citations

Structure and mechanism of the hammerhead self-cleaving domain.

1989 • 4 citations

Substitution of non-catalytic stem and loop regions of hammerhead ribozyme with DNA counterparts only increases KM without sacrificing the catalytic step (kcat): a way to improve substrate-specificity.

1992 • 3 citations

Structure and mechanism of the hammerhead self-cleaving domain.

1989 • 2 citations