Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

Why Nature Chose Phosphates

1987 • 1,583 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

1981 • 877 citations

NUCLEOSIDE PHOSPHOROTHIOATES

1985 • 830 citations

The Chemistry of Self-Splicing RNA and RNA Enzymes

1987 • 523 citations

The Intervening Sequence RNA of Tetrahymena Is an Enzyme

1986 • 498 citations

Biological Catalysis by RNA

1986 • 496 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage–ligation reaction

1983 • 287 citations

The Tetrahymena ribozyme acts like an RNA restriction endonuclease

1986 • 285 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

1988 • 251 citations

DNA and RNA Sequence Determination Based on Phosphorothioate Chemistry

1988 • 226 citations

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity

1986 • 211 citations

A Labile Phosphodiester Bond at the Ligation Junction in a Circular Intervening Sequence RNA

1984 • 171 citations

Absolute configuration of the diastereomers of adenosine 5'-O-(1-thiotriphosphate): consequences for the stereochemistry of polymerization by DNA-dependent RNA polymerase from Escherichia coli.

1978 • 164 citations

Diastereomers of 5'-O-adenosyl 3'-O-uridyl phosphorothioate: chemical synthesis and enzymic properties

1979 • 149 citations

Splice-site selection by a self-splicing RNA of Tetrahymena

1986 • 134 citations

Rate-limiting steps in the DNA polymerase I reaction pathway

1985 • 133 citations

Stereospecificity of nucleases towards phosphorothioate-substituted RNA: stereochemistry of transcription by T7 RNA polymerase

1987 • 126 citations

Transient Kinetic Studies of the Mg++-dependent ATPase of Myosin and Its Proteolytic Subfragments

1973 • 91 citations

6 Chemical Basis of Biological Phosphoryl Transfer

1973 • 86 citations

Stereochemistry of the transesterification step of ribonuclease T1

1972 • 79 citations

The self-splicing RNA of Tetrahymena is trapped in a less active conformation by gel purification

1990 • 76 citations

Kinetics for reaction of a circularized intervening sequence with CU, UCU, CUCU, and CUCUCU: mechanistic implications from the dependence on temperature and on oligomer and magnesium concentrations

1988 • 56 citations

The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase

1986 • 54 citations

Mechanistic studies on deoxyribonucleic acid dependent ribonucleic acid polymerase from Escherichia coli using phosphorothioate analog. 1. Initiation and pyrophosphate exchange reactions

1979 • 49 citations

The rate of hydrolysis of some p‐nitrophenol esters of ortho‐phosphoric‐ and thio‐phosphoric acid

1952 • 42 citations

Autolytic processing of a phosphorothioate diester bond

1988 • 38 citations

RNA mediated formation of a phosphorothioate diester bond

1988 • 35 citations

S-Methylated nucleoside phosphorothioates as probes of enzyme metal.cntdot.nucleotide binding sites

1982 • 10 citations