Insulin‐like growth factor‐1 mRNA is increased in deafferented hippocampus: Spatiotemporal correspondence of a trophic event with axon sprouting

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Lectin binding by resting and reactive microglia

1987 • 497 citations

Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site

1982 • 477 citations

Plasticity of Hippocampal Circuitry in Alzheimer's Disease

1985 • 457 citations

Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions

1972 • 451 citations

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors.

1990 • 441 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts

1976 • 385 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection

1992 • 367 citations

Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro

1988 • 361 citations

Transient IGF-I gene expression during the maturation of functionally related central projection neurons

1991 • 287 citations

Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve

1989 • 280 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

The process of reinnervation in the dentate gyrus of the adult rat: A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis

1983 • 252 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

1991 • 245 citations

Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes

1991 • 245 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

1990 • 238 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Insulin‐like growth factors: Putative muscle‐derived trophic agents that promote motoneuron survival

1993 • 225 citations

Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.

1992 • 223 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

MHC class II‐positive microglia in human brain: Association with alzheimer lesions

1992 • 221 citations

Complementary DNA cloning and sequencing of rat ovarian basic fibroblast growth factor and tissue distribution study of its mRNA

1988 • 210 citations

Proliferative and migratory activity of glial cells in the partially deafferented hippocampus

1979 • 197 citations

Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain

1990 • 194 citations

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

1987 • 190 citations

Cholinergic sprouting in the hippocampus: A proposed role for IL-1

1990 • 187 citations

In Vitro Evidence for Two Distinct Hippocampal Growth Factors: Basis of Neuronal Plasticity?

1982 • 177 citations

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

1985 • 174 citations

Spreading depression increases immunohistochemical staining of glial fibrillary acidic protein

1991 • 167 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus

1991 • 142 citations

Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus

1993 • 135 citations

Motor Nerve Sprouting and Acetylcholine Receptors

1978 • 135 citations

Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions

1987 • 132 citations

Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat

1977 • 131 citations

Role of insulin-like growth factors in peripheral nerve regeneration

1994 • 130 citations

Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system

1993 • 124 citations

Seizures increase basic fibroblast growth factor mRNA in adult rat forebrain neurons and glia

1994 • 117 citations

Insulin-like growth factors in the response to cerebral ischemia

1992 • 116 citations

Trophic effects of insulin-like growth factor-I on fetal rat hypothalamic cells in culture

1990 • 109 citations

Expression of insulin-like growth factor I by astrocytes in response to injury

1992 • 109 citations

Insulin-Like Growth Factors

1990 • 108 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation

1989 • 103 citations

Vault immunofluorescence in the brain: new insights regarding the origin of microglia

1991 • 100 citations

Mechanisms of sprouting in the adult central nervous system: Cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus

1994 • 99 citations

Morphometric Analysis of Microglia in Alzheimerʼs Disease

1993 • 91 citations

Effects of insulin and insulin-like growth factors on neurofilament mRNA and tubulin mRNA content in human neuroblastoma SH-SY5Y cells

1992 • 89 citations

Temporal parameters of axon “sprouting” in the brain of the adult rat

1977 • 86 citations

Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region

1987 • 85 citations

Antibody to NGF inhibits collateral sprouting of septohippocampal fibers following entorhinal cortex lesion in adult rats

1992 • 85 citations

Microglia are associated with the extracellular neurofibrillary tangles of alzheimer disease

1991 • 83 citations

Receptor Binding, Endocytosis, and Mitogenesis of Insulin‐Like Growth Factors I and II in Fetal Rat Brain Neurons

1991 • 83 citations

The Process of Reinnervation in the Dentate Gyrus of Adult Rats: Temporal Relationship between Changes in the Levels of Glial Fibrillary Acidic Protein (GFAP) and GFAP mRNA in Reactive Astrocytes

1993 • 82 citations

Elevated insulin-like growth factor (IGF) gene expression in sciatic nerves during IGF-supported nerve regeneration

1994 • 80 citations

Basic fibroblast growth factor modulates insulin-like growth factor-I, its receptor, and its binding proteins in hypothalamic cell cultures.

1992 • 78 citations

Evidence for selective post-lesion axonal growth in the dentate gyrus of the rat

1974 • 72 citations

Changes in nerve growth factor immunoreactivity following entorhinal cortex lesions: Possible molecular mechanism regulating cholinergic sprouting

1994 • 65 citations

Signals that induce sprouting in the central nervous system: Sprouting is delayed in a strain of mouse exhibiting delayed axonal degeneration

1992 • 64 citations

Insulin‐like growth factor‐I (IGF‐I) production by astroglial cells: Regulation and importance for epidermal growth factor‐induced cell replication

1993 • 62 citations

Entorhinal cortex lesion induces differential responses in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in the rat hippocampal formation

1993 • 59 citations

Activity‐Sensitive Signaling by Muscle‐Derived Insulin‐like Growth Factors in the Developing and Regenerating Neuromuscular System

1993 • 55 citations

Mitogenic activity of epidermal growth factor on newborn rat astroglia: interaction with insulin-like growth factors.

1992 • 55 citations

Insulin influences astroglial morphology and glial fibrillary acidic protein (GFAP) expression in organotypic cultures

1991 • 55 citations

Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for glial fibrillary acidic protein in cortex and hippocampus: inhibition by MK-801

1993 • 54 citations

Electrolytic entorhinal lesions cause seizures

1982 • 52 citations

Increase of extracellular insulin-like growth factor I (IGF-I) concentration following electrolytical lesion in rat hippocampus

1991 • 44 citations

Interleukin-1β increases basic fibroblast growth factor mRNA expression in adult rat brain and organotypic hippocampal cultures

1994 • 42 citations

BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions

1993 • 42 citations

bFGF induces its own gene expression in astrocytic and hippocampal cell cultures

1992 • 41 citations

Spreading depression induces c-fos-like immunoreactivity and NGF mRNA in the rat cerebral cortex

1993 • 41 citations

Regulation of Nerve Growth Factor mRNA in the Hippocampal Formation: Effects of N-Methyl-d-aspartate Receptor Activation

1993 • 39 citations

Somatomedins in aging and dementia disorders of the Alzheimer type

1982 • 39 citations

Do neurotrophic interactions control synapse formation in the adult rat brain?

1980 • 38 citations

Epileptogenic effects of electrolytic lesions in the hippocampus: Role of iron deposition

1984 • 35 citations

Trophic Actions of IGF-I, IGF-II and Insulin on Cholinergic and Dopaminergic Brain Neurons

1991 • 32 citations

Neurotrophic factor mRNA expression in dentate gyrus is increased following angular bundle transection

1994 • 31 citations

Basic Fibroblast Growth Factor in the Mature Brain and Its Possible Role in Alzheimer's Disease

1991 • 22 citations

MK-801 affects the potassium-induced increase of glial fibrillary acidic protein immunoreactivity in rat brain

1992 • 19 citations

Comparative Anatomy of the Hippocampus

1990 • 17 citations

Binding of [125I]-Insulin-Like Growth Factor-1 (IGF-1) in Brains of Alzheimer’s and Alcoholic Patients

1991 • 5 citations