Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Oncogenes and signal transduction

1991 • 2,816 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture

1995 • 847 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

1994 • 704 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

The Control of Neuron Number

1988 • 573 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Structural and quantitative studies on the normal C3H and lurcher mutant mouse

1979 • 483 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

Ca2+-Dependent Routes to Ras: Mechanisms for Neuronal Survival, Differentiation, and Plasticity?

1996 • 262 citations

Calcium influx induces neurite growth through a Src-Ras signaling cassette

1995 • 261 citations

Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes

1996 • 239 citations

Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells

1996 • 216 citations

Sustained increase in intracellular calcium promotes neuronal survival

1991 • 213 citations

Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes

1983 • 197 citations

Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival

1996 • 176 citations

Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels.

1996 • 174 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

1993 • 161 citations

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.

1993 • 160 citations

Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.

1991 • 159 citations

Survival, morphology and adhesion properties of cerebellar interneurones cultured in chemically defined and serum-supplemented medium

1985 • 157 citations

Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.

1986 • 147 citations

Direct correlation between Purkinje and granule cell number in the cerebella of lurcher chimeras and wild-type mice

1983 • 135 citations

Activation of PRK1 by Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate

1995 • 127 citations

The role of dihydropyridine-sensitive voltage-gated calcium channels in potassium-mediated neuronal survival

1989 • 127 citations

Effects of high K+ concentrations on the growth and development of ciliary ganglion neurons in cell culture

1981 • 116 citations

Rapid onset of neuronal death induced by blockade of either axoplasmic transport or action potentials in afferent fibers during brain development

1992 • 112 citations

Neurotrophic effects of NMDA receptor activation on developing cerebellar granule cells

1993 • 106 citations

Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity

1993 • 103 citations

Inhibition of p42 and p44 Mitogen‐Activated Protein Kinase Activity by PD98059 Does Not Suppress Nerve Growth Factor‐Induced Survival of Sympathetic Neurones

1996 • 100 citations

Methods in inositide research

1991 • 99 citations

Afferent spontaneous electrical activity promotes the survival of target cells in the developing retinotectal system of the rat

1993 • 89 citations

Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission

1988 • 83 citations

A target for phosphoinositide 3-kinase: Akt/PKB

1995 • 80 citations

Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase

1995 • 75 citations

A rapid fluorometric assay to measure neuronal survival in vitro

1993 • 63 citations

Phosphatidylinositol( , , ) -Trisphosphate Stimulates Phosphorylation of Pleckstrin in Human Platelets

1995 • 56 citations

Chronic blockade of bioelectric activity in neonatal rat cortex grown in vitro: Morphological effects

1991 • 55 citations

Intracellular Signalling: PI 3-kinase puts GTP on the Rac

1995 • 53 citations

Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors

1995 • 48 citations

Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin

1995 • 37 citations

Involvement of phosphatidylinositol 3-kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes.

1995 • 23 citations

Purification and characterization of a polyphosphoinositide phosphatase from rat brain.

1994 • 16 citations

Cell-Cycle-Dependent Modulation of EGF-Receptor-Mediated Signaling

1995 • 12 citations