Insulin-like Growth Factor I (IGF-I) Induces Unique Effects in the Cytoskeleton of Cultured Rat Glomerular Mesangial Cells

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

1993 • 515 citations

Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.

1991 • 461 citations

Function follows form: generation of intracellular signals by cell deformation

1991 • 345 citations

Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.

1979 • 325 citations

ELECTRON MICROSCOPY OF CELLS AND TISSUES

1956 • 325 citations

Lamin B constitutes an intermediate filament attachment site at the nuclear envelope.

1987 • 306 citations

Endocytosis: Relation to Capping and Cell Locomotion

1984 • 292 citations

Enhanced expression of “muscle-specific” actin in glomerulonephritis

1992 • 268 citations

Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels.

1986 • 256 citations

Glomerular cells in culture

1983 • 237 citations

Two distinct attachment sites for vimentin along the plasma membrane and the nuclear envelope in avian erythrocytes: a basis for a vectorial assembly of intermediate filaments.

1987 • 227 citations

Beta actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury.

1991 • 216 citations

Animal cell shape changes and gene expression

1991 • 212 citations

Influence of the angiotensin system on endothelial and smooth muscle cell migration.

1990 • 184 citations

Beta and gamma actin mRNAs are differentially located within myoblasts

1993 • 169 citations

Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture.

1986 • 165 citations

A comprehensive analysis of the developmental and tissue-specific expression of the isoactin multigene family in the rat

1991 • 162 citations

Clinical Uses of Insulin-like Growth Factor I

1994 • 138 citations

Medical aspects of the actin cytoskeleton

1995 • 130 citations

The contribution of glomerular mesangial cells to progressive glomerulosclerosis.

1989 • 126 citations

Studies on Binding and Mitogenic Effect of Insulin and Insulin-Like Growth Factor I in Glomerular Mesangial Cells*

1988 • 125 citations

Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells

1988 • 104 citations

Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen

1995 • 99 citations

Autocrine control of wound repair by insulin-like growth factor I in cultured endothelial cells

1993 • 95 citations

Serum-induced signal transduction determines the peripheral location of beta-actin mRNA within the cell.

1994 • 93 citations

Looking for a function

1987 • 87 citations

Controlled induction of focal adhesion disassembly and migration in primary fibroblasts

1993 • 76 citations

Identification of two distinct functional domains on vinculin involved in its association with focal contacts.

1989 • 75 citations

Synthesis and Binding of Insulin-Like Growth Factor I by Human Glomerular Mesangial Cells*

1989 • 73 citations

Insulin and Insulin-Like Growth Factor I Binding to Cultured Rat Glomerular Mesangial Cells*

1988 • 65 citations

Interactions of intermediate filaments with cell structures

1990 • 64 citations

Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85.

1992 • 63 citations

Insulin-Like Growth Factor-1 Therapy in Diabetes: Physiologic Basis, Clinical Benefits, and Risks

1994 • 62 citations

Rat models for clinical use of insulin-like growth factor I in acute renal failure

1994 • 62 citations

Latch-bridge model in smooth muscle: [Ca2+]i can quantitatively predict stress

1990 • 62 citations

Expression of alpha-smooth muscle actin in the developing kidney vasculature.

1992 • 60 citations

Growth factors in renal development.

1995 • 60 citations

Intracellular actin as a marker for myofibroblasts in vitro.

1992 • 57 citations

Synthesis and release of insulinlike growth factor I by mesangial cells in culture

1988 • 56 citations

Induction of nodular sclerosis by insulin in rat mesangial cells in vitro: Studies of collagen

1995 • 56 citations

Role of the Cytoskeleton in Genome Regulation and Cancer

1992 • 51 citations

Glomerular mesangial cell migration in response to platelet-derived growth factor.

1990 • 50 citations

Insulin induces a change in extracellular matrix glycoproteins synthesized by rat mesangial cells in culture

1994 • 50 citations

The spatial distribution of exposed nuclear DNA in normal, cancer, and reverse-transformed cells.

1990 • 48 citations

Tumor necrosis factor induces contraction of mesangial cells and alters their cytoskeletons

1990 • 41 citations

Mesangial cells from diabetic NOD mice constitutively secrete increased amounts of insulin-like growth factor-I.

1993 • 39 citations

Cytoskeletal changes associated with cell motility.

1993 • 32 citations

Growth-mediated, density-dependent inhibition of endocytosis in cultured arterial smooth muscle cells

1980 • 31 citations

Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression.

1991 • 29 citations

Discordant, organ-specific regulation of insulin-like growth factor-I messenger ribonucleic acid in insulin-deficient diabetes in rats.

1993 • 22 citations

Trophic effect of insulin-like growth factor-I on metanephric development: relationship to proteoglycans.

1994 • 16 citations

Insulin-like growth factors as endocrine and paracrine hormones

1992 • 16 citations

Effect of cytokines on the cytoskeleton of resident glomerular cells.

1993 • 15 citations

Presence of a distinct extracellular matrix-degrading metalloproteinase activity in renal tubules.

1994 • 14 citations

Insulin induces rapid and specific rearrangement of the cytoskeleton of rat mesangial cells in vitro.

1996 • 14 citations

Microfilaments and protein synthesis; effects of insulin

1993 • 14 citations

The cellular response to factors which induce motility in mammalian cells

1991 • 7 citations