The effects of interferon-γ on the central nervous system

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin

1965 • 710 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Immune interferon: a pleiotropic lymphokine with multiple effects

1985 • 676 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

1994 • 570 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

Structure of the human immune interferon gene

1982 • 510 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Cloning and expression of murine immune interferon cDNA.

1983 • 455 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Induction of MHC Class I Genes in Neurons

1995 • 446 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Three-dimensional structure of recombinant human interferon-gamma

1991 • 420 citations

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

1983 • 417 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

1995 • 393 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

Establishment and characterization of multipotent neural cell lines using retrovirus vector‐mediated oncogene transfer

1990 • 375 citations

Role of interferon-gamma in immune cell regulation.

1995 • 374 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Nervous tissue as an immune compartment: the dialect of the immune response in the CNS

1994 • 366 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

1994 • 343 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I Expression

1991 • 308 citations

The Biochemical Pathology of Astrocytes

1989 • 299 citations

Role of interferon-γ in immune cell regulation

1995 • 295 citations

Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis

1983 • 287 citations

The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion

1994 • 284 citations

Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.

1995 • 283 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

Interferon-γ-Induced Oligodendrocyte Cell Death: Implications for the Pathogenesis of Multiple Sclerosis

1995 • 249 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

1989 • 227 citations

Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo.

1991 • 217 citations

Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse.

1994 • 216 citations

Inflammatory mediators in demyelinating disorders of the CNS and PNS

1992 • 213 citations

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

1990 • 207 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Multiple Sclerosis: Immune System Molecule Expression in the Central Nervous System

1994 • 200 citations

Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes

1995 • 197 citations

Targeted CNS Expression of Interferon-γ in Transgenic Mice Leads to Hypomyelination, Reactive Gliosis, and Abnormal Cerebellar Development

1996 • 184 citations

Interferon-γ induces the expression of H-2 and Ia antigens on brain cells

1984 • 182 citations

Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice.

1988 • 172 citations

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.

1995 • 172 citations

Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.

1986 • 164 citations

Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation

1990 • 163 citations

Reversible Inhibitory Effects of Interferon‐γ and Tumour Necrosis Factor‐α on Oligodendroglial Lineage Cell Proliferation and Differentiation In Vitro

1996 • 162 citations

Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

1995 • 158 citations

Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse

1992 • 156 citations

Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

1996 • 149 citations

Ultrastructure of Multiple Sclerosis

1994 • 148 citations

Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma

1992 • 146 citations

The Jak Kinases Differentially Associate with the α and β (Accessory Factor) Chains of the Interferon γ Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors

1995 • 143 citations

Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.

1995 • 140 citations

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 • 136 citations

T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes

1993 • 136 citations

Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells

1993 • 131 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains

1994 • 122 citations

Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes

1991 • 116 citations

The effect of cytokines on the expression and function of Fc receptors for IgG on human myeloid cells

1990 • 109 citations

Differential regulation of oligodendrocyte markers by glucocorticoids: post-transcriptional regulation of both proteolipid protein and myelin basic protein and transcriptional regulation of glycerol phosphate dehydrogenase.

1989 • 109 citations

Cytokines and the CNS

2005 • 109 citations

Interferon-activated signal transduction to the nucleus

1994 • 108 citations

RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma.

1995 • 107 citations

Differential expression and regulation of major histocompatibility complex (MHC) products in neural and glial cells of the human fetal brain

1988 • 104 citations

Interferons in Multiple Sclerosis

1992 • 104 citations

T helper cell differentiation in immune response

1995 • 104 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon

1988 • 101 citations

Molecular cloning of a cDNA encoding the “61-kDa” calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms.

1993 • 99 citations

Neuronal cells are deficient in loading peptides onto MHC class I molecules

1992 • 96 citations

Cytokines and Murine Autoimmune Encephalomyelitis: Inhibition or Enhancement of Disease with Antibodies to Select Cytokines, or by Delivery of Exogenous Cytokines Using a Recombinant Vaccinia Virus System

1995 • 95 citations

Cell type‐specific regulation of major histocompatibility complex (MHC) Class I gene expression in astrocytes, oligodendrocytes, and neurons

1993 • 94 citations

Tissue-specific targeting of gytokine unresponsiveness in transgenic mice

1995 • 94 citations

Effects of interferon-gamma on primary cultures of human brain microvessel endothelial cells.

1993 • 94 citations

Selective Killing of Cholinergic Neurons by Microglial Activation in Basal Forebrain Mixed Neuronal/Glial Cultures

1995 • 88 citations

The blood-brain barrier in health and disease

1987 • 87 citations

The expression of MHC antigens on oligodendrocytes: Induction of polymorphic H-2 expression by lymphokines

1986 • 84 citations

Cytokine production by cells in cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice

1994 • 84 citations

Interferon Suppresses Sympathetic Neuronal Cell Death Caused by Nerve Growth Factor Deprivation

1990 • 84 citations

Differential proliferative response of human and mouse astrocytes to gamma‐interferon

1992 • 84 citations

Cytokine-Induced Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Cultured Human Oligodendrocytes and Astrocytes

1991 • 83 citations

Stoichiometry of interaction between interferon γ and its receptor

1992 • 76 citations

Expression of heat shock protein‐65 by oligodendrocytes in vivo and in vitro

1992 • 75 citations

Preliminary studies of cytokine-induced functional effects on the visual pathways in the rabbit

1989 • 72 citations

The pathogenesis of multiple sclerosis

1993 • 71 citations

Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system.

1995 • 68 citations

Effects of glycosidase treatment on the physicochemical properties and biological activity of human interferon-gamma.

1983 • 68 citations

Interferon‐γ potentiates antibody‐mediated demyelination in vivo

1992 • 65 citations

Heat shock proteins: Applications in health and disease

1996 • 64 citations

Localization of aldosterone and corticosterone in the central nervous system, assessed by quantitative autoradiography

1984 • 64 citations

γ-Interferon promotes differentiation of cultured cortical and hippocampal neurons

1991 • 61 citations

Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes

1991 • 58 citations

Myelin proteolipid protein: minimum sequence requirements for active induction of autoimmune encephalomyelitis in SWR/J and SJL/J mice

1992 • 58 citations

Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity.

1987 • 56 citations

Differential roles of multiple adhesion molecules in cell migration: Granule cell migration in cerebellum

1990 • 51 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Transgenic mouse model for central nervous system demyelination.

1991 • 51 citations

Expression of interferon-gamma receptors on murine oligodendrocytes and its regulation by cytokines and mitogens.

1995 • 50 citations

Induction of human hsp60 expression in monocytic cell lines

1992 • 49 citations

Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation.

1989 • 48 citations

Transcription factors in interferon signaling

1995 • 46 citations

IFN-γ facilitates NGF-induced neuronal differentiation in PC12 cells

1988 • 45 citations

TRAUMA AND MULTIPLE SCLEROSIS

1964 • 45 citations

Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-γ and TNF-α

1991 • 44 citations

Induction of ICAM-1 on human neural cells and mechanisms of neutrophil-mediated injury.

1991 • 44 citations

Heat shock protein immunoreactivity in CSF

1994 • 44 citations

Cultured human fetal astrocytes can be induced by interferon-γ to express HLA-DR

1987 • 43 citations

In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules.

1992 • 42 citations

Expression of the neu oncogene under the transcriptional control of the myelin basic protein gene in transgenic mice: Generation of transformed glial cells

1992 • 41 citations

Demonstration of α, β, and γ Interferon in Active Chronic Multiple Sclerosis Lesionsa

1988 • 39 citations

Interferon pretreatment lowers the threshold for maximal heat‐shock response in mouse cells

1986 • 36 citations

Recent Progress in the Elucidation of Interferon-Gamma Actions: Molecular Biology and Biological Functions

1994 • 36 citations

The differentiation of O‐2A progenitor cells into oligodendrocytes is associated with a loss of inducibility of Ia antigens

1988 • 35 citations

Demonstration of the presence of a specific interferon-γ receptor on murine astrocyte cell surface

1991 • 31 citations

Major histocompatibility complex Class I expression in oligodendrocytes induces hypomyelination in transgenic mice

1996 • 28 citations

The Role of T Cells in Multiple Sclerosis: Implications for Therapies Targeting the T Cell Receptor

1994 • 26 citations

Trauma and multiple sclerosis

1987 • 26 citations

Interferon γ Potentiates Human Coronavirus OC43 Infection of Neuronal Cells by Modulation of HLA Class I Expression

1995 • 16 citations

Cytokine signal transduction.

1995 • 14 citations

Morphological and molecular response of the MOCH‐1 oligodendrocyte cell line to serum and interferon‐γ: Possible implications for demyelinating disorders

1995 • 10 citations

Dysmyelination in class I MHC transgenic mice

1995 • 8 citations

MOCH-1 Cells: An Oligodendrocyte Cell Line Generated Using a Transgenic Approach

1994 • 2 citations