In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules.

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Monoclonal antibody to a plasma membrane antigen of neurons.

1979 • 965 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Identification of Ia glycoproteins in rat thymus and purification from rat spleen

1979 • 682 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

1983 • 417 citations

Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions

1986 • 383 citations

Emergence of three myelin proteins in oligodendrocytes cultured without neurons.

1986 • 333 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages

1985 • 316 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

1989 • 266 citations

Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease

1991 • 254 citations

Biochemical effects of corticosteroids on neural tissues

1985 • 248 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

1986 • 214 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls

1991 • 196 citations

Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes

1986 • 184 citations

Multiple Sclerosis as a Disease of Immune Regulation

1984 • 169 citations

Interferon-γ and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions

1988 • 142 citations

Type II glucocorticoid receptors are expressed in oligodendrocytes and astrocytes

1990 • 134 citations

Protein-antigen specific Ia-restricted cytolytic T cells: analysis of frequency, target cell susceptibility, and mechanism of cytolysis.

1985 • 122 citations

Expression of specific cytolytic activity by H-2I region-restricted, influenza virus-specific T lymphocyte clones.

1985 • 119 citations

Differential regulation of oligodendrocyte markers by glucocorticoids: post-transcriptional regulation of both proteolipid protein and myelin basic protein and transcriptional regulation of glycerol phosphate dehydrogenase.

1989 • 109 citations

Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.

1989 • 108 citations

Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

1986 • 105 citations

Lymphocyte subpopulations in patients with multiple sclerosis.

1983 • 86 citations

Schwann cells co‐cultured with stimulated T cells and antigen express major histocompatibility complex (MHC) class II determinants without interferon‐γ pretreatment: synergistic effects of interferon‐γ and tumor necrosis factor on MHC class II induction

1989 • 77 citations

High-affinity fluorescent peptide binding to I-Ad in lipid membranes.

1986 • 73 citations

MS: a localized immune disease of the central nervous system

1989 • 72 citations

The pathogenesis of demyelinating disease: insights from cell biology

1991 • 70 citations

Localization of aldosterone and corticosterone in the central nervous system, assessed by quantitative autoradiography

1984 • 64 citations

Multiple sclerosis: Oligodendrocytes in active lesions do not express class II major histocompatibility complex molecules

1989 • 60 citations

Induction of macrophage Ia antigen expression by rIFN-gamma and down-regulation by IFN-alpha/beta and dexamethasone are regulated transcriptionally.

1988 • 57 citations

Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity.

1987 • 56 citations

Recovery of myelination in rat optic nerve after developmental retardation by cortisol

1982 • 52 citations

Regulation of class II MHC molecules on human endothelial cells. Effects of IFN and dexamethasone.

1988 • 51 citations

Gamma interferon, but notMycobacterium leprae, induces major histocompatibility class II antigens on cultured rat Schwann cells

1987 • 50 citations

Rat Schwann cells can be induced to express major histocompatibility complex class II moleculesin vivo

1992 • 50 citations

Cytolytic activity of antigen-specific T cells with helper phenotype.

1986 • 50 citations

Expression of Ia antigens on the surface of human oligodendrocytes and astrocytes in culture

1985 • 44 citations

Cultured human and rat oligodendrocytes and rat schwann cells do not have immune response gene associated antigen (Ia) on their surface

1983 • 44 citations

Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones.

1985 • 42 citations

Basic protein-specific T-cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice: Comparison with lewis rat lines

1988 • 41 citations

Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells

1984 • 37 citations

The differentiation of O‐2A progenitor cells into oligodendrocytes is associated with a loss of inducibility of Ia antigens

1988 • 35 citations

The class II genes of the rat MHC.

1989 • 35 citations

The mitotic history and radiosensitivity of developing oligodendrocytes in vitro

1984 • 30 citations

DNA sequence analysis of a rat RT1 class 11 A ? gene

1985 • 27 citations

Characteristics of in vitro cytotoxic effects of myelin basic protein-reactive T cell lines on syngeneic oligodendrocytes

1990 • 12 citations

The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.

1990 • 11 citations

Hydrocortisone induction during oligodendroglial differentiation

1990 • 10 citations

Pathogenesis of a Third World disease: lessons from leprosy.

1988 • 1 citations

Pathogenesis of a Third World disease: lessons from leprosy.

1988 • 1 citations