Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon.

1985 • 397 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Molecular Transductional Mechanisms by which IFNγ and Other Signals Regulate Macrophage Development

1987 • 266 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

γ-Interferon is one of several direct B cell-maturing lymphokines

1984 • 237 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation

1990 • 163 citations

Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.

1991 • 157 citations

Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic.

1986 • 145 citations

The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones.

1983 • 141 citations

Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon‐γ

1990 • 139 citations

Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

1990 • 130 citations

Interleukin-6 is elevated in plasma in multiple sclerosis

1991 • 129 citations

Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis

1986 • 124 citations

MHC control of CD4+ T cell subset activation.

1989 • 121 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 • 107 citations

Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon

1988 • 101 citations

Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses.

1991 • 89 citations

Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and γ-IFN levels in serum and cerebrospinal fluid

1989 • 88 citations

Depletion of CD8+ T cells suppresses growth of Trypanosoma brucei brucei and interferon-gamma) production in infected rats

1990 • 86 citations

Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis.

1988 • 83 citations

Facial Nerve Transection Causes Expansion of Myelin Autoreactive T Cells in Regional Lymph Nodes and T Cell Homing to the Facial Nucleus

1992 • 81 citations

Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis

1992 • 81 citations

Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

1991 • 80 citations

Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells.

1987 • 74 citations

Immunosuppression and lymphoid hypoplasia associated with chronic graft versus host disease is dependent upon IFN-gamma production.

1990 • 68 citations

Interferon induces astrocyte maturation causing an increase in cholinergic properties of cultured human spinal cord cells

1989 • 60 citations

Regulation of macrophage function by interferon-gamma. Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition, the oxidative burst, and expression of the chronic granulomatous disease gene.

1990 • 59 citations

Induction of Ia molecules on brain endothelium is related to susceptibility to experimental allergic encephalomyelitis

1989 • 46 citations

Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis

1989 • 38 citations

Human T lymphocyte response to myelin basic protein: Selection of T lymphocyte lines from mbp‐responsive donors

1989 • 30 citations

CD5+ B cells and CD4−8− T cells in neuroimmunological diseases

1991 • 29 citations

Inhibition of macrophage-induced antigen-specific T-cell proliferation by interferon-γ

1988 • 29 citations

T cell responses to human recombinant acetylcholine receptor‐α subunitin myasthenia gravis and controls

1992 • 25 citations

Assessment of the inhibitory effect of immunosuppressive agents on rat T cell interferon-γ production using an ELISPOT assay

1991 • 21 citations

Increased interleukin-1 production by peripheral blood mononuclear cells in patients with multiple sclerosis

1991 • 20 citations