Interferon‐γ potentiates antibody‐mediated demyelination in vivo

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes

1977 • 777 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Identification of Ia glycoproteins in rat thymus and purification from rat spleen

1979 • 682 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Ameboid microglia as effectors of inflammation in the central nervous system

1987 • 477 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

THE EFFECTS OF EXPERIMENTAL DEMYELINATION ON CONDUCTION IN THE CENTRAL NERVOUS SYSTEM

1970 • 375 citations

MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon

1987 • 346 citations

A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody

1984 • 318 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Comparative Neuropathology of Chronic Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1983 • 295 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition

1989 • 269 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

1989 • 227 citations

Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)

1987 • 217 citations

Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions

1988 • 206 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls

1991 • 196 citations

THE EFFECTS OF EXPERIMENTAL DEMYELINATION ONCONDUCTION IN PERIPHERAL NERVE: A HISTOLOGICAL AND ELECTROPHYSIOLOGICAL STUDY

1963 • 182 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

Demyelination Induced in Aggregating Brain Cell Cultures by a Monoclonal Antibody Against Myelin/Oligodendrocyte Glycoprotein

1990 • 165 citations

Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies.

1982 • 160 citations

THE ROLE OF COMPLEMENT IN THE PATHOGENESIS OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

1989 • 156 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 136 citations

The role of interferon‐gamma in the pathogenesis of experimental autoimmune disease of the peripheral nervous system

1990 • 120 citations

Studies on demyelination by activated lymphocytes in the rabbit eye. II. Antibody-dependent cell-mediated demyelination.

1977 • 98 citations

Studies on autoimmune encephalomyelitis in the guinea pig. II. An in vitro investigation on the nature, properties, and specificity of the serum-demyelinating factor.

1976 • 92 citations

The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids.

1987 • 83 citations

Respiratory burst activity in brain macrophages: a flow cytometric study on cultured rat microglia

1991 • 74 citations

Preliminary studies of cytokine-induced functional effects on the visual pathways in the rabbit

1989 • 72 citations

Interferon γ: a master key in the immune system

1988 • 72 citations

Studies on Demyelination by Activated Lymphocytes in the Rabbit Eye

1977 • 71 citations

The pathogenesis of demyelinating disease: insights from cell biology

1991 • 70 citations

Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination

1989 • 69 citations

Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain.

1989 • 69 citations

In vivo effect of sera from animals with chronic relapsing experimental allergic encephalomyelitis on central and peripheral myelin

1981 • 65 citations

Immunohistochemical localisation of terminal complement component C9 in experimental allergic encephalomyelitis

1989 • 59 citations

Concomitant detection of changes in myelin basic protein and permeability of blood-spinal cord barrier in acute experimental autoimmune encephalomyelitis by electroimmunoblotting

1985 • 52 citations

Induction of recurrent experimental allergic encephalomyelitis with myelin basic protein

1981 • 52 citations

The Effect of Gamma Interferon on IL-1 Secretion of In Vitro Differentiated Human Macrophages

1985 • 46 citations

Functional antagonism between type I and type II interferons on human macrophages

1986 • 44 citations

Differential induction of activation markers in macrophage cell lines by interferon-γ

1989 • 37 citations

PHYSIOLOGICAL CONSEQUENCES OF ANTISERUM-MEDIATED EXPERIMENTAL DEMYELINATION IN CNS

1988 • 35 citations

In vivo CNS demyelination mediated by anti-galactocerebroside antibody

1989 • 34 citations

Analysis of Humoral and Cellular Events and the Role of Lipid Haptens During CNS Demyelination

1983 • 33 citations

The pathophysiology of acute experimental allergic encephalomyelitis induced by whole spinal cord in the Lewis rat

1988 • 32 citations

Antiviral antibodies stimulate production of reactive oxygen species in cultured canine brain cells infected with canine distemper virus

1989 • 32 citations

Progress in Neuropathology

1987 • 31 citations

Demyelination and early remyelination in experimental allergic encephalomyelitis passively ransferred with myelin basic protein-sensitized lymphocytes in the Lewis rat

1989 • 27 citations

Pathophysiology of Demyelination^a

1984 • 25 citations

Chronic experimental autoimmune encephalomyelitis in the guinea pig. Presence of anti-M2 antibodies in central nervous system tissue and the possible role of M2 autoantigen in the induction of the disease

1989 • 24 citations

ELECTROPHYSIOLOGICAL INVESTIGATIONS IN ADOPTIVELY TRANSFERRED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN THE LEWIS RAT

1989 • 23 citations

Serum anti-myelin antibodies in chronic relapsing experimental allergic encephalomyelitis

1988 • 12 citations

Ultrastructural study of central nervous system demyelination in galactocerebroside sensitized rabbits.

1986 • 12 citations

Activation of macrophages by recombinant interferon-γ has no effect on myelin phagocytosis but hinders invasion of nerves in organ culture

1989 • 11 citations

Pathogenetic aspects of multiple sclerosis and experimental models of inflammatory demyelination.

1985 • 9 citations

Medicine at the end of life

1987 • 5 citations

Familial megaconial myopathy: A real nosologic entity

1983 • 3 citations

Demyelinating Diseases

2016 • 2 citations